دورية أكاديمية
أعرض في EDS

Conscious sedation using propofol versus midazolam in cirrhotic patients during upper GI endoscopy: A comparative study.

التفاصيل البيبلوغرافية
العنوان: Conscious sedation using propofol versus midazolam in cirrhotic patients during upper GI endoscopy: A comparative study.
المؤلفون: Wahab EA; Department of Internal Medicine., Hamed EF; Department of Internal Medicine., Ahmad HS; Department of Clinical Pathology., Abdel Monem SM; Department of Tropical Medicine Zagazig University Hospitals Zagazig Egypt., Fathy T; Department of Tropical Medicine Zagazig University Hospitals Zagazig Egypt.
المصدر: JGH open : an open access journal of gastroenterology and hepatology [JGH Open] 2018 Oct 23; Vol. 3 (1), pp. 25-31. Date of Electronic Publication: 2018 Oct 23 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Australia, Ltd Country of Publication: Australia NLM ID: 101730833 Publication Model: eCollection Cited Medium: Internet ISSN: 2397-9070 (Electronic) Linking ISSN: 23979070 NLM ISO Abbreviation: JGH Open Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Richmond, Victoria, Australia] : John Wiley & Sons Australia, Ltd., [2017]-
مستخلص: Aim: We aimed to assess the safety and efficacy of propofol versus midazolam in cirrhotic patients undergoing upper GI endoscopy.
Methods: Ninety compensated cirrhotic patients (all met class I-III criteria according to the American Society of Anesthesia) were enrolled in this comparative study. They were classified into three groups according to scheduled pre-endoscopy sedation drugs; the midazolam group, which included 30 patients who received IV weight-dependent midazolam (0.05 mg/kg with additional doses of 1 mg every 2 min when necessary, up to a maximum dose of 0.1 mg/kg or 10 mg); the propofol group, which included 30 patients who received a propofol bolus dose according to age and weight (0.25 mg/kg with additional doses of 20-30 mg every 30-60 s when necessary, up to a maximum dose of 400 mg); and the combined group, which included 30 patients who received half a dose of midazolam and of propofol.
Results: Prolonged postendoscopy recovery times were reported in the midazolam group, while shorter recovery times were reported in the propofol and combined groups. All patients in the propofol and combined groups gained consciousness shortly postendoscopy; however, only half of the midazolam group's patients gained consciousness after the standard recovery time (10-30 min). Highly significant differences were found among the three groups regarding consciousness level according to the Glasgow coma scale, as well as regarding the occurrence of hypoxia during endoscopy.
Conclusion: Considering safety and efficacy issues, propofol is better than midazolam in gastrointestinal endoscopy, especially in patients with liver cirrhosis.
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فهرسة مساهمة: Keywords: endoscopy; liver cirrhosis; midazolam; pre‐endoscopy sedation; propofol
تواريخ الأحداث: Date Created: 20190306 Latest Revision: 20240714
رمز التحديث: 20240714
مُعرف محوري في PubMed: PMC6386741
DOI: 10.1002/jgh3.12098
PMID: 30834337
قاعدة البيانات: MEDLINE
الوصف
تدمد:2397-9070
DOI:10.1002/jgh3.12098