دورية أكاديمية
Effects of Honey on Postprandial Hyperlipidemia and Oxidative Stress in Wistar Rats: Role of HMG-CoA Reductase Inhibition and Antioxidant Effect.
| العنوان: | Effects of Honey on Postprandial Hyperlipidemia and Oxidative Stress in Wistar Rats: Role of HMG-CoA Reductase Inhibition and Antioxidant Effect. |
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| المؤلفون: | Erejuwa OO; Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki, Ebonyi State. erejuwa@gmail.com., Akpan JL, Uwaezuoke NJI, Nwobodo NN, Ezeokpo BC, Erhiano E, Araromi EJ, Ude UN, AbdulWahab M, Sulaiman SA |
| المصدر: | Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria [Niger J Physiol Sci] 2018 Dec 30; Vol. 33 (2), pp. 129-138. Date of Electronic Publication: 2018 Dec 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Physiological Society of Nigeria Country of Publication: Nigeria NLM ID: 8811109 Publication Model: Electronic Cited Medium: Internet ISSN: 0794-859X (Print) Linking ISSN: 0794859X NLM ISO Abbreviation: Niger J Physiol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Benin City, Nigeria : Physiological Society of Nigeria |
| مواضيع طبية MeSH: | Honey*, Antioxidants/*pharmacology , Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology , Hyperlipidemias/*drug therapy , Oxidative Stress/*drug effects, Animals ; Cholesterol/metabolism ; Hydroxymethylglutaryl CoA Reductases/drug effects ; Rats, Wistar |
| مستخلص: | Postprandial hyperlipidemia is associated with oxidative stress and is an important risk factor for atherosclerosisand cardiovascular disease. The aims of this study were to investigate the antihyperlipidemic effect of honey administered 5or 60 minutes before a high-fat diet (HFD), to explore the role of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA)reductase in antihyperlipidemic effect of honey and to investigate the effect of honey on postprandial oxidative stress. Ratswere fasted and randomized into 5 groups. Groups 1 and 2 were administered portable water. After 60 minutes, the groupswere given portable water and HFD, respectively. Group 3 was administered honey. After 5 minutes, the rats were givenHFD. Groups 4 and 5 were administered honey and simvastatin, respectively. After 60 minutes, the rats were given HFD.Four hours after portable water or HFD administration, the rats were sacrificed. Group 2 had significantly (p < 0.01) highertotal cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) cholesterol, very low density lipoprotein (VLDL)cholesterol, catalase activity and significantly (p < 0.05) lower high density lipoprotein (HDL) cholesterol and HMG-CoA:mevalonate (p < 0.001) compared with Group 1. Group 3 had significantly (p < 0.01) higher TG and VLDL cholesterol andlower HMG-CoA: mevalonate compared with Group 1. Groups 4 and 5 exhibited significantly (p < 0.05 or p < 0.001) higherHDL cholesterol and HMG-CoA: mevalonate and lower LDL cholesterol compared with group 2. Honey pretreatment 60minutes before HFD feeding exerts more significant antihyperlipidemic effect and attenuates more considerably postprandialhyperlipidemia-induced oxidative stress than honey administered 5 minutes before HFD in Wistar rats. This markedantihyperlipidemic effect of honey pretreatment is mediated in part via inhibition of HMG-CoA reductase. |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors) 97C5T2UQ7J (Cholesterol) EC 1.1.1.- (Hydroxymethylglutaryl CoA Reductases) |
| تواريخ الأحداث: | Date Created: 20190307 Date Completed: 20190528 Latest Revision: 20190528 |
| رمز التحديث: | 20221213 |
| PMID: | 30837765 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0794-859X |
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