دورية أكاديمية
Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis.
| العنوان: | Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis. |
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| المؤلفون: | Ladinsky MS; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Araujo LP; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Zhang X; Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA., Veltri J; Department of Pharmacology, Physiology and Neurosciences, Rutgers University, Newark, NJ 07103, USA., Galan-Diez M; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Soualhi S; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Lee C; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Irie K; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.; Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan., Pinker EY; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Narushima S; RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan., Bandyopadhyay S; Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA., Nagayama M; RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan.; Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi 329-0498, Japan., Elhenawy W; Department of Biochemistry & Biomedical Sciences, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada., Coombes BK; Department of Biochemistry & Biomedical Sciences, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada., Ferraris RP; Department of Pharmacology, Physiology and Neurosciences, Rutgers University, Newark, NJ 07103, USA., Honda K; RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan.; Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan., Iliev ID; Department of Microbiology and Immunology and The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY 10065, USA., Gao N; Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. bjorkman@caltech.edu ii2137@cumc.columbia.edu., Ivanov II; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. bjorkman@caltech.edu ii2137@cumc.columbia.edu. |
| المصدر: | Science (New York, N.Y.) [Science] 2019 Mar 08; Vol. 363 (6431). |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science |
| أسماء مطبوعة: | Publication: Original Publication: New York, N.Y. : [s.n.] 1880- |
| مواضيع طبية MeSH: | Antigens, Bacterial/*immunology , Endocytosis/*immunology , Gastrointestinal Microbiome/*immunology , Host Microbial Interactions/*immunology , Intestinal Mucosa/*immunology , Intraepithelial Lymphocytes/*immunology , Th17 Cells/*immunology, Animals ; Bacteria/immunology ; Endocytosis/genetics ; Homeostasis/genetics ; Lymphocyte Activation ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Symbiosis ; cdc42 GTP-Binding Protein/genetics ; cdc42 GTP-Binding Protein/physiology |
| مستخلص: | Commensal bacteria influence host physiology, without invading host tissues. We show that proteins from segmented filamentous bacteria (SFB) are transferred into intestinal epithelial cells (IECs) through adhesion-directed endocytosis that is distinct from the clathrin-dependent endocytosis of invasive pathogens. This process transfers microbial cell wall-associated proteins, including an antigen that stimulates mucosal T helper 17 (T (Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.) |
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| معلومات مُعتمدة: | P50 GM082545 United States GM NIGMS NIH HHS; F31 DK121428 United States DK NIDDK NIH HHS; R21 AI126305 United States AI NIAID NIH HHS; R21 AI146817 United States AI NIAID NIH HHS; R01 DK102934 United States DK NIDDK NIH HHS; R01 AT010243 United States AT NCCIH NIH HHS; P50 AI150464 United States AI NIAID NIH HHS; R01 DK098378 United States DK NIDDK NIH HHS |
| المشرفين على المادة: | 0 (Antigens, Bacterial) 0 (Cdc42 protein, mouse) EC 3.6.5.2 (cdc42 GTP-Binding Protein) |
| تواريخ الأحداث: | Date Created: 20190309 Date Completed: 20190819 Latest Revision: 20230930 |
| رمز التحديث: | 20230930 |
| مُعرف محوري في PubMed: | PMC6708280 |
| DOI: | 10.1126/science.aat4042 |
| PMID: | 30846568 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1095-9203 |
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| DOI: | 10.1126/science.aat4042 |