دورية أكاديمية
أعرض في EDS

Local resources of polyribosomes and SER promote synapse enlargement and spine clustering after long-term potentiation in adult rat hippocampus.

التفاصيل البيبلوغرافية
العنوان: Local resources of polyribosomes and SER promote synapse enlargement and spine clustering after long-term potentiation in adult rat hippocampus.
المؤلفون: Chirillo MA; Center for Learning and Memory, Department of Neuroscience, The University of Texas at Austin, Austin, Texas, 78712, USA.; Fulbright U.S. Scholar Program, University of Belgrade, Studentski trg 1, Belgrade, 11000, Serbia., Waters MS; Center for Learning and Memory, Department of Neuroscience, The University of Texas at Austin, Austin, Texas, 78712, USA.; McGovern Medical School in Houston, 6431 Fannin St., Houston, TX, 77030, USA., Lindsey LF; Center for Learning and Memory, Department of Neuroscience, The University of Texas at Austin, Austin, Texas, 78712, USA.; Google Seattle, Seattle, Washington, 98103, USA., Bourne JN; Center for Learning and Memory, Department of Neuroscience, The University of Texas at Austin, Austin, Texas, 78712, USA.; Department of Cell and Developmental Biology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, 80045, USA., Harris KM; Center for Learning and Memory, Department of Neuroscience, The University of Texas at Austin, Austin, Texas, 78712, USA. kharris@mail.clm.utexas.edu.
المصدر: Scientific reports [Sci Rep] 2019 Mar 07; Vol. 9 (1), pp. 3861. Date of Electronic Publication: 2019 Mar 07.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Dendritic Spines/*metabolism , Endoplasmic Reticulum, Smooth/*metabolism , Hippocampus/*metabolism , Long-Term Potentiation/*physiology , Polyribosomes/*metabolism , Synapses/*metabolism, Animals ; Dendritic Spines/ultrastructure ; Endoplasmic Reticulum, Smooth/ultrastructure ; Hippocampus/ultrastructure ; Male ; Polyribosomes/ultrastructure ; Rats, Long-Evans ; Synapses/ultrastructure ; Tissue Culture Techniques
مستخلص: Synapse clustering facilitates circuit integration, learning, and memory. Long-term potentiation (LTP) of mature neurons produces synapse enlargement balanced by fewer spines, raising the question of how clusters form despite this homeostatic regulation of total synaptic weight. Three-dimensional reconstruction from serial section electron microscopy (3DEM) revealed the shapes and distributions of smooth endoplasmic reticulum (SER) and polyribosomes, subcellular resources important for synapse enlargement and spine outgrowth. Compared to control stimulation, synapses were enlarged two hours after LTP on resource-rich spines containing polyribosomes (4% larger than control) or SER (15% larger). SER in spines shifted from a single tubule to complex spine apparatus after LTP. Negligible synapse enlargement (0.6%) occurred on resource-poor spines lacking SER and polyribosomes. Dendrites were divided into discrete synaptic clusters surrounded by asynaptic segments. Spine density was lowest in clusters having only resource-poor spines, especially following LTP. In contrast, resource-rich spines preserved neighboring resource-poor spines and formed larger clusters with elevated total synaptic weight following LTP. These clusters also had more shaft SER branches, which could sequester cargo locally to support synapse growth and spinogenesis. Thus, resources appear to be redistributed to synaptic clusters with LTP-related synapse enlargement while homeostatic regulation suppressed spine outgrowth in resource-poor synaptic clusters.
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معلومات مُعتمدة: NS71442 International U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS); MH095980 International U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH); MH104319 International U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
تواريخ الأحداث: Date Created: 20190309 Date Completed: 20200924 Latest Revision: 20200924
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6405867
DOI: 10.1038/s41598-019-40520-x
PMID: 30846859
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-019-40520-x