دورية أكاديمية
أعرض في EDS

Comparative effectiveness of drugs used to constrict the patent ductus arteriosus: a secondary analysis of the PDA-TOLERATE trial (NCT01958320).

التفاصيل البيبلوغرافية
العنوان: Comparative effectiveness of drugs used to constrict the patent ductus arteriosus: a secondary analysis of the PDA-TOLERATE trial (NCT01958320).
المؤلفون: Liebowitz M; Department of Pediatrics, University of California, San Francisco, CA, USA., Kaempf J; Providence St. Vincent Medical Center, Portland, OR, USA., Erdeve O; Ankara University School of Medicine Children's Hospital, Ankara, Turkey., Bulbul A; Sisli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey., Håkansson S; Umea University Hospital, Umea, Sweden., Lindqvist J; Umea University Hospital, Umea, Sweden., Farooqi A; Umea University Hospital, Umea, Sweden., Katheria A; Sharp Mary Birch Hospital, San Diego, CA, USA., Sauberan J; Sharp Mary Birch Hospital, San Diego, CA, USA., Singh J; University of Chicago, Chicago, IL, USA., Nelson K; University of Chicago, Chicago, IL, USA., Wickremasinghe A; Kaiser Permanente Santa Clara Medical Center, Santa Clara, CA, USA., Dong L; Kaiser Permanente Santa Clara Medical Center, Santa Clara, CA, USA., Hassinger DC; Morristown Medical Center, Morristown, NJ, USA., Aucott SW; Johns Hopkins University, Baltimore, MD, USA., Hayashi M; Johns Hopkins University, Baltimore, MD, USA., Heuchan AM; University of Glasgow, Royal Hospital for Sick Children, Glasgow, Scotland, UK., Carey WA; Mayo Clinic, Rochester, MN, USA., Derrick M; Northshore University Health System, Evanston, IL, USA., Wolf IS; Northshore University Health System, Evanston, IL, USA., Kimball A; University of California San Diego and Rady Children's Hospital, San Diego, CA, USA., Sankar M; Good Samaritan Hospital, San Jose, CA, USA., Leone T; Columbia University Medical Center, New York, NY, USA., Perez J; South Miami Hospital/Baptist Health South Florida, Miami, FL, USA., Serize A; South Miami Hospital/Baptist Health South Florida, Miami, FL, USA., Clyman RI; Department of Pediatrics, University of California, San Francisco, CA, USA. clymanr@peds.ucsf.edu.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA. clymanr@peds.ucsf.edu.
المصدر: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2019 May; Vol. 39 (5), pp. 599-607. Date of Electronic Publication: 2019 Mar 08.
نوع المنشور: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 8501884 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5543 (Electronic) Linking ISSN: 07438346 NLM ISO Abbreviation: J Perinatol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2001- : New York, NY : Nature Publishing Group
Original Publication: [Philadelphia, Pa. : W.B. Saunders, c1984-
مواضيع طبية MeSH: Acetaminophen/*therapeutic use , Ductus Arteriosus, Patent/*drug therapy , Ibuprofen/*therapeutic use , Indomethacin/*therapeutic use , Vasoconstriction/*drug effects, Administration, Intravenous ; Administration, Oral ; Conservative Treatment ; Ductus Arteriosus/drug effects ; Female ; Humans ; Infant, Extremely Premature ; Infant, Newborn ; Male ; San Francisco ; Treatment Outcome
مستخلص: Objective: To evaluate the effectiveness of drugs used to constrict patent ductus arteriosus (PDA) in newborns < 28 weeks.
Methods: We performed a secondary analysis of the multi-center PDA-TOLERATE trial (NCT01958320). Infants with moderate-to-large PDAs were randomized 1:1 at 8.1 ± 2.1 days to either Drug treatment (n = 104) or Conservative management (n = 98). Drug treatments were assigned by center rather than within center (acetaminophen: 5 centers, 27 infants; ibuprofen: 7 centers, 38 infants; indomethacin: 7 centers, 39 infants).
Results: Indomethacin produced the greatest constriction (compared with spontaneous constriction during Conservative management): RR (95% CI) = 3.21 (2.05-5.01)), followed by ibuprofen = 2.03 (1.05-3.91), and acetaminophen = 1.33 (0.55-3.24). The initial rate of acetaminophen-induced constriction was 27%. Infants with persistent moderate-to-large PDA after acetaminophen were treated with indomethacin. The final rate of constriction after acetaminophen ± indomethacin was 60% (similar to the rate in infants receiving indomethacin-alone (62%)).
Conclusion: Indomethacin was more effective than acetaminophen in producing ductus constriction.
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معلومات مُعتمدة: UL1 TR001872 United States TR NCATS NIH HHS; R01 HL109199 United States HL NHLBI NIH HHS; UL1 TR001873 United States TR NCATS NIH HHS; UL1 TR000004 United States TR NCATS NIH HHS
سلسلة جزيئية: ClinicalTrials.gov NCT01958320
المشرفين على المادة: 362O9ITL9D (Acetaminophen)
WK2XYI10QM (Ibuprofen)
XXE1CET956 (Indomethacin)
تواريخ الأحداث: Date Created: 20190310 Date Completed: 20200519 Latest Revision: 20240717
رمز التحديث: 20240717
مُعرف محوري في PubMed: PMC6561645
DOI: 10.1038/s41372-019-0347-4
PMID: 30850756
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-5543
DOI:10.1038/s41372-019-0347-4