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TouchScreen-based phenotyping: altered stimulus/reward association and lower perseveration to gain a reward in mu opioid receptor knockout mice.

التفاصيل البيبلوغرافية
العنوان: TouchScreen-based phenotyping: altered stimulus/reward association and lower perseveration to gain a reward in mu opioid receptor knockout mice.
المؤلفون: Boulos LJ; Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada., Nasseef MT; Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada., McNicholas M; Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada., Mechling A; Department of Radiology, Medical Physics, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Harsan LA; Department of Radiology, Medical Physics, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Engineering science, computer science and imaging laboratory (ICube), Integrative Multimodal Imaging in Healthcare, University of Strasbourg - CNRS, Strasbourg, France.; Department of Biophysics and Nuclear Medicine, Faculty of Medicine, University Hospital Strasbourg, Strasbourg, France., Darcq E; Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada., Ben Hamida S; Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada., Kieffer BL; Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada. brigitte.kieffer@douglas.mcgill.ca.
المصدر: Scientific reports [Sci Rep] 2019 Mar 11; Vol. 9 (1), pp. 4044. Date of Electronic Publication: 2019 Mar 11.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Behavior, Animal*, Motivation/*genetics , Prefrontal Cortex/*metabolism , Receptors, Opioid, mu/*genetics, Animals ; Female ; Male ; Mice ; Mice, Knockout ; Nucleus Accumbens ; Prefrontal Cortex/pathology ; Receptors, Opioid, mu/metabolism ; Reward ; Self Administration
مستخلص: While the contribution of Mu Opioid Receptors (MORs) to hedonic aspects of reward processing is well-established, the notion that these receptors may also regulate motivation to gain a reward, and possibly other related cognitive dimensions, has been less investigated. The prefrontal cortex (PFC) is a critical site for these processes. Our previous functional magnetic resonance imaging study found alterations of functional connectivity (FC) in reward/aversion networks in MOR knockout mice. Here we pursued voxelwise seed-based FC analyses using the same dataset with a focus on the PFC. We observed significant reduction of PFC FC in mutant mice, predominantly with the nucleus accumbens, supporting the notion of altered reward-driven top-down controls. We tested motivation for palatable food in a classical operant self-administration paradigm, and found delayed performance for mutant mice. We then evaluated motivational and cognitive abilities of MOR knockout mice in TouchScreen-based behavioral tests. Learning was delayed and stimulus/reward association was impaired, suggesting lower hedonic reward value and reduced motivation. Perseverative responses were decreased, while discriminatory behavior and attention were unchanged, indicative of increased inhibitory controls with otherwise intact cognitive performance. Together, our data suggest that MORs contribute to enhance reward-seeking and facilitate perseverative behaviors. The possibility that MOR blockade could reduce maladaptive compulsivity deserves further investigation in addiction and self-control disorder research.
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معلومات مُعتمدة: P50 DA005010 United States DA NIDA NIH HHS
المشرفين على المادة: 0 (Receptors, Opioid, mu)
تواريخ الأحداث: Date Created: 20190313 Date Completed: 20200925 Latest Revision: 20210109
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6411729
DOI: 10.1038/s41598-019-40622-6
PMID: 30858487
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-019-40622-6