دورية أكاديمية
Why is sterility virulence most common in sexually transmitted infections? Examining the role of epidemiology.
| العنوان: | Why is sterility virulence most common in sexually transmitted infections? Examining the role of epidemiology. |
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| المؤلفون: | McLeod DV; Institute of Integrative Biology, ETH Zürich, Zürich, Switzerland., Day T; Department of Mathematics and Statistics, Department of Biology Queen's University, Kingston, Ontario, Canada. |
| المصدر: | Evolution; international journal of organic evolution [Evolution] 2019 May; Vol. 73 (5), pp. 872-882. Date of Electronic Publication: 2019 Mar 25. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0373224 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-5646 (Electronic) Linking ISSN: 00143820 NLM ISO Abbreviation: Evolution Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : Oxford : Oxford University Press Original Publication: Lancaster, Pa. : Society for the Study of Evolution |
| مواضيع طبية MeSH: | Infertility/*complications , Infertility/*epidemiology , Sexually Transmitted Diseases/*complications , Sexually Transmitted Diseases/*epidemiology, Animals ; Biological Evolution ; Ecosystem ; Host-Pathogen Interactions/genetics ; Models, Genetic ; Normal Distribution ; Population Density ; Population Dynamics ; Sexual Behavior, Animal ; Stochastic Processes ; Virulence |
| مستخلص: | Sterility virulence, or the reduction in host fecundity due to infection, occurs in many host-pathogen systems. Notably, sterility virulence is more common for sexually transmitted infections (STIs) than for directly transmitted pathogens, while other forms of virulence tend to be limited in STIs. This has led to the suggestion that sterility virulence may have an adaptive explanation. By focusing upon finite population models, we show that the observed patterns of sterility virulence can be explained by consideration of the epidemiological differences between STIs and directly transmitted pathogens. In particular, when pathogen transmission is predominantly density invariant (as for STIs), and mortality is density dependent, sterility virulence can be favored by demographic stochasticity, whereas if pathogen transmission is predominantly density dependent, as is common for most directly transmitted pathogens, sterility virulence is disfavored. We show these conclusions can hold even if there is a weak selective advantage to sterilizing. (© 2019 The Author(s). Evolution © 2019 The Society for the Study of Evolution.) |
| فهرسة مساهمة: | Keywords: Infectious disease; sexually transmitted infections; sterility; stochasticity; virulence evolution |
| سلسلة جزيئية: | Dryad 10.5061/dryad.70423j5 |
| تواريخ الأحداث: | Date Created: 20190313 Date Completed: 20200708 Latest Revision: 20200708 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/evo.13718 |
| PMID: | 30859562 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1558-5646 |
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| DOI: | 10.1111/evo.13718 |