دورية أكاديمية
Characteristics, risks, and outcomes of post-transplant lymphoproliferative disease >3 years after pediatric heart transplant: A multicenter analysis.
| العنوان: | Characteristics, risks, and outcomes of post-transplant lymphoproliferative disease >3 years after pediatric heart transplant: A multicenter analysis. |
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| المؤلفون: | West SC; Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania., Friedland-Little JM; Seattle Children's Hospital, Seattle, Washington., Schowengerdt KO Jr; Cardinal Glennon Children's Medical Center, Saint Louis University, St. Louis, Missouri., Naftel DC; University of Alabama at Birmingham, Birmingham, Alabama., Pruitt Freeze E; University of Alabama at Birmingham, Birmingham, Alabama., Smith KS; Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania., Urschel S; University of Alberta, Edmonton, Alberta, Canada., Michaels MG; Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania., Kirklin JK; University of Alabama at Birmingham, Birmingham, Alabama., Feingold B; Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania. |
| المصدر: | Clinical transplantation [Clin Transplant] 2019 May; Vol. 33 (5), pp. e13521. Date of Electronic Publication: 2019 Apr 04. |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Munksgaard Country of Publication: Denmark NLM ID: 8710240 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-0012 (Electronic) Linking ISSN: 09020063 NLM ISO Abbreviation: Clin Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Copenhagen : Munksgaard, |
| مواضيع طبية MeSH: | Graft Rejection/*mortality , Heart Transplantation/*mortality , Lymphoproliferative Disorders/*mortality , Postoperative Complications/*mortality, Adolescent ; Canada/epidemiology ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Graft Rejection/epidemiology ; Graft Survival ; Humans ; Incidence ; Infant ; Infant, Newborn ; Lymphoproliferative Disorders/pathology ; Lymphoproliferative Disorders/surgery ; Male ; Prognosis ; Prospective Studies ; Retrospective Studies ; Risk Factors ; Survival Rate ; United States/epidemiology |
| مستخلص: | Post-transplant lymphoproliferative disorder (PTLD) is a significant complication after pediatric heart transplantation (HT), occurring in 5%-15% of patients within 3 years. Data >3 years from HT are limited. We sought to describe the prevalence, risk factors, and outcomes of PTLD occurring late (>3 years) after pediatric HT in the Pediatric Heart Transplant Study from 1993 to 2010. Among 3844 primary HT patients, 110 (3%) developed late, nonrecurrent PTLD. The hazard rate for late PTLD was constant at 0.01 events/year out to 20 years after HT. Risk factors for late PTLD were younger age at HT (HR 1.06, P = 0.003) and Epstein-Barr virus (EBV) naivety (HR 1.65, P = 0.02). Survival after late PTLD was 86% and 68% at 1 and 5 years, with nonwhite race (HR 2.27, P = 0.03) and earlier year of HT (HR 1.03, P = 0.04) independently associated with mortality. Acute rejection and infection were both common after late PTLD, occurring in 26% and 34% of patients. The constant late hazard and contribution of EBV to late PTLD suggest that vigilance for development of PTLD, including for EBV conversion, should persist indefinitely after pediatric HT. The reasons for elevated risk of death for nonwhites after late PTLD are unclear and warrant further investigation. (© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
| فهرسة مساهمة: | Keywords: Epstein-Barr virus; heart transplant; pediatric transplant; post-transplant lymphoproliferative; post-transplant lymphoproliferative disorder |
| تواريخ الأحداث: | Date Created: 20190313 Date Completed: 20200716 Latest Revision: 20200716 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/ctr.13521 |
| PMID: | 30861200 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1399-0012 |
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| DOI: | 10.1111/ctr.13521 |