دورية أكاديمية
أعرض في EDS

Immune- and non-immune-mediated roles of regulatory T-cells during wound healing.

التفاصيل البيبلوغرافية
العنوان: Immune- and non-immune-mediated roles of regulatory T-cells during wound healing.
المؤلفون: Zaiss DM; Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK., Minutti CM; Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK.; Immunobiology Laboratory, The Francis Crick Institute, London, UK., Knipper JA; Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK.
المصدر: Immunology [Immunology] 2019 Jul; Vol. 157 (3), pp. 190-197. Date of Electronic Publication: 2019 Apr 09.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0374672 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2567 (Electronic) Linking ISSN: 00192805 NLM ISO Abbreviation: Immunology Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Blackwell Scientific Publications
مواضيع طبية MeSH: Wound Healing*, Extracellular Matrix/*immunology , T-Lymphocytes, Regulatory/*immunology, Amphiregulin/metabolism ; Animals ; Autocrine Communication ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Humans ; Interleukin-33/metabolism ; Signal Transduction ; T-Lymphocytes, Regulatory/metabolism ; Transforming Growth Factor beta/metabolism
مستخلص: The immune system has a well-established contribution to tissue homeostasis and wound healing. However, in many cases immune responses themselves can cause severe tissue damage. Thus, the question arose to which extent cells of the immune system directly contribute to the process of wound healing and to which extent the resolution of excessive immune responses may indirectly contribute to wound healing. FoxP3-expressing CD4 T-cells, so-called regulatory T-cells (T regs ), have an important contribution in the regulation of immune responses; and, in recent years, it has been suggested that T regs next to an immune-regulatory, 'damage-limiting' function may also have an immune-independent 'damage-resolving' direct role in wound healing. In particular, the release of the epidermal growth factor-like growth factor Amphiregulin by tissue-resident T regs during wound repair suggested such a function. Our recent findings have now revealed that Amphiregulin induces the local release of bio-active transforming growth factor (TGF)β, a cytokine involved both in immune regulation as well as in the process of wound repair. In light of these findings, we discuss whether, by locally activating TGFβ, T reg -derived Amphiregulin may contribute to both wound repair and immune suppression. Furthermore, we propose that T reg -derived Amphiregulin in an autocrine way may enable an IL-33-mediated survival and expansion of tissue-resident T regs upon injury. Furthermore, T reg -derived Amphiregulin may contribute to a constitutive, low-level release of bio-active TGFβ within tissues, leading to continuous tissue regeneration and to an immune-suppressive environment, which may keep inflammation-prone tissues in an homeostatic state.
(© 2019 John Wiley & Sons Ltd.)
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معلومات مُعتمدة: MR/M011755/1 United Kingdom MRC_ Medical Research Council
فهرسة مساهمة: Keywords: Amphiregulin; IL-33; cytokines/cytokine receptors; regulation/suppression; signal transduction; tissue-resident Tregs
المشرفين على المادة: 0 (AREG protein, human)
0 (Amphiregulin)
0 (IL33 protein, human)
0 (Interleukin-33)
0 (Transforming Growth Factor beta)
تواريخ الأحداث: Date Created: 20190314 Date Completed: 20191206 Latest Revision: 20210109
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6600083
DOI: 10.1111/imm.13057
PMID: 30866049
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2567
DOI:10.1111/imm.13057