دورية أكاديمية
Bactericidal and Biocompatible Properties of Plasma Chemical Oxidized Titanium (TiOB ® ) with Antimicrobial Surface Functionalization.
العنوان: | Bactericidal and Biocompatible Properties of Plasma Chemical Oxidized Titanium (TiOB ® ) with Antimicrobial Surface Functionalization. |
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المؤلفون: | Kranz S; Department of Conservative Dentistry and Periodontology, University Hospital Jena, An der Alten Post 4, 07743 Jena, Germany. Stefan.Kranz@med.uni-jena.de., Guellmar A; Department of Conservative Dentistry and Periodontology, University Hospital Jena, An der Alten Post 4, 07743 Jena, Germany. Andre.Guellmar@med.uni-jena.de., Voelpel A; Department of Conservative Dentistry and Periodontology, University Hospital Jena, An der Alten Post 4, 07743 Jena, Germany. Andrea.Voelpel@med.uni-jena.de., Lesser T; Department of Conservative Dentistry and Periodontology, University Hospital Jena, An der Alten Post 4, 07743 Jena, Germany. Tobias.Lesser@med.uni-jena.de., Tonndorf-Martini S; Department of Conservative Dentistry and Periodontology, University Hospital Jena, An der Alten Post 4, 07743 Jena, Germany. Silke.Tonndorf-Martini@med.uni-jena.de., Schmidt J; Innovent Technology Development, Prüssingstraße 27 B, 07745 Jena, Germany. js@innovent-jena.de., Schrader C; Innovent Technology Development, Prüssingstraße 27 B, 07745 Jena, Germany. cs@innovent-jena.de., Faucon M; Königsee Implantate GmbH, OT-Aschau-Am Sand 4, 07426 Allendorf, Germany. Mathilde.Faucon@koenigsee-implantate.de., Finger U; Königsee Implantate GmbH, OT-Aschau-Am Sand 4, 07426 Allendorf, Germany. Ulrich.Finger@koenigsee-implantate.de., Pfister W; Department of Microbiology, University Hospital Jena, Erlanger Allee 101, 07747 Jena, Germany. Wolfgang.Pfister@med.uni-jena.de., Diefenbeck M; Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Jena, Erlanger Allee 101, 07747 Jena, Germany. Michael.Diefenbeck@bonesupport.com., Sigusch B; Department of Conservative Dentistry and Periodontology, University Hospital Jena, An der Alten Post 4, 07743 Jena, Germany. bernd.w.sigusch@med.uni-jena.de. |
المصدر: | Materials (Basel, Switzerland) [Materials (Basel)] 2019 Mar 15; Vol. 12 (6). Date of Electronic Publication: 2019 Mar 15. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101555929 Publication Model: Electronic Cited Medium: Print ISSN: 1996-1944 (Print) Linking ISSN: 19961944 NLM ISO Abbreviation: Materials (Basel) Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: May 2010- : Basel, Switzerland : MDPI Original Publication: Basel, Switzerland : Molecular Diversity Preservation International, 2008-2010. |
مستخلص: | Coating of plasma chemical oxidized titanium (TiOB ® ) with gentamicin-tannic acid (TiOB ® gta) has proven to be efficient in preventing bacterial colonization of implants. However, in times of increasing antibiotic resistance, the development of alternative antimicrobial functionalization strategies is of major interest. Therefore, the aim of the present study is to evaluate the antibacterial and biocompatible properties of TiOB ® functionalized with silver nanoparticles (TiOB ® SiOx Ag) and ionic zinc (TiOB ® Zn). Antibacterial efficiency was determined by agar diffusion and proliferation test on Staphylocuccus aureus. Cytocompatibility was analyzed by direct cultivation of MC3T3-E1 cells on top of the functionalized surfaces for 2 and 4 d. All functionalized surfaces showed significant bactericidal effects expressed by extended lag phases (TiOB ® gta for 5 h, TiOB ® SiOx Ag for 8 h, TiOB ® Zn for 10 h). While TiOB ® gta (positive control) and TiOB ® Zn remained bactericidal for 48 h, TiOB ® SiOx Ag was active for only 4 h. After direct cultivation for 4 d, viable MC3T3-E1 cells were found on all surfaces tested with the highest biocompatibility recorded for TiOB ® SiOx Ag. The present study revealed that functionalization of TiOB ® with ionic zinc shows bactericidal properties that are comparable to those of a gentamicin-containing coating. |
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فهرسة مساهمة: | Keywords: MC3T3-E1; Staphylococcus aureus; antibacterial coating; cytotoxicity; dental implants; gentamicin; plasma chemical oxidation; silver; titanium implants; zinc |
تواريخ الأحداث: | Date Created: 20190317 Latest Revision: 20201001 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC6470708 |
DOI: | 10.3390/ma12060866 |
PMID: | 30875882 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1996-1944 |
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DOI: | 10.3390/ma12060866 |