دورية أكاديمية
Frontoparietal network abnormalities of gray matter volume and functional connectivity in patients with generalized anxiety disorder.
العنوان: | Frontoparietal network abnormalities of gray matter volume and functional connectivity in patients with generalized anxiety disorder. |
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المؤلفون: | Ma Z; The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, Jiangsu, China; Cognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, Jiangsu, China., Wang C; The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, Jiangsu, China; Cognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, Jiangsu, China; School of Psychology, Nanjing Normal University, Nanjing, Jiangsu, China., Hines CS; South Texas Veterans Healthcare System, University of Texas Health San Antonio, United States., Lu X; The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, Jiangsu, China; Cognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, Jiangsu, China; School of Psychology, Nanjing Normal University, Nanjing, Jiangsu, China., Wu Y; The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, Jiangsu, China; Cognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, Jiangsu, China; School of Psychology, Nanjing Normal University, Nanjing, Jiangsu, China., Xu H; The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, Jiangsu, China; Cognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, Jiangsu, China., Li J; The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, Jiangsu, China; Cognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, Jiangsu, China., Wang Q; The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, Jiangsu, China; Cognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, Jiangsu, China; School of Psychology, Nanjing Normal University, Nanjing, Jiangsu, China., Pang M; The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, Jiangsu, China; Cognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, Jiangsu, China., Zhong Y; School of Psychology, Nanjing Normal University, Nanjing, Jiangsu, China; Jiangsu Key Laboratory of Mental Health and Cognitive Science, Nanjing Normal University, Nanjing, Jiangsu, China. Electronic address: fmrizhongy@126.com., Zhang N; The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, Jiangsu, China; Cognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, Jiangsu, China. |
المصدر: | Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2019 Apr 30; Vol. 286, pp. 24-30. Date of Electronic Publication: 2019 Mar 02. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101723001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7506 (Electronic) Linking ISSN: 09254927 NLM ISO Abbreviation: Psychiatry Res Neuroimaging Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier |
مواضيع طبية MeSH: | Anxiety Disorders/*diagnostic imaging , Frontal Lobe/*diagnostic imaging , Gray Matter/*diagnostic imaging , Magnetic Resonance Imaging/*methods , Nerve Net/*diagnostic imaging , Parietal Lobe/*diagnostic imaging, Adult ; Anxiety Disorders/physiopathology ; Anxiety Disorders/psychology ; Female ; Frontal Lobe/physiology ; Gray Matter/physiology ; Humans ; Male ; Middle Aged ; Nerve Net/physiology ; Organ Size/physiology ; Parietal Lobe/physiology ; Young Adult |
مستخلص: | We hypothesized that the frontoparietal region would exhibit differences in gray matter volume (GMV) and resting-state functional connectivity (rs-FC) in patients with generalized anxiety disorder (GAD) versus healthy controls (HCs). We also aimed to report on correlations between these neuroradiological findings and HAMA scores. We recruited 27 patients with GAD and 28 HCs, matched for gender, age and education. GMV was estimated using voxel-based morphometry (VBM). We found decreased GMV in the precentral gyrus (PrCG) and the superior frontal gyrus (SFG) in patients with GAD, which were used as regions of interest (ROI) for rs-FC analyses. We detected enhanced rs-FC in the inferior frontal gyrus (IFG) based on an increase in negative connections, and reduced rs-FC in the superior temporal gyrus (STG) based on a decrease in positive connections compared to HCs. The right PrCG may be a candidate biomarker in patients with GAD, as well as a potential stimulation target for improvement of anxiety symptoms. By combining GMV and rs-FC analyses, our findings help to understand the pathophysiology of GAD by combining GMV and rs-FC. (Copyright © 2019 Elsevier B.V. All rights reserved.) |
فهرسة مساهمة: | Keywords: Frontoparietal networks; Generalized anxiety disorder; Gray matter volume; ROC; Resting-state functional connectivity |
تواريخ الأحداث: | Date Created: 20190317 Date Completed: 20200210 Latest Revision: 20200210 |
رمز التحديث: | 20231215 |
DOI: | 10.1016/j.pscychresns.2019.03.001 |
PMID: | 30877889 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1872-7506 |
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DOI: | 10.1016/j.pscychresns.2019.03.001 |