دورية أكاديمية
أعرض في EDS

Innate immune response in patients with acute Zika virus infection.

التفاصيل البيبلوغرافية
العنوان: Innate immune response in patients with acute Zika virus infection.
المؤلفون: da Silva MHM; Graduate Program in Parasitary Biology, Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande Do Norte, Brazil., Moises RNC; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande Do Norte, Brazil., Alves BEB; Graduate Program in Parasitary Biology, Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande Do Norte, Brazil.; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande Do Norte, Brazil.; Laboratory of Virology, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil., Pereira HWB; Graduate Program in Parasitary Biology, Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande Do Norte, Brazil.; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande Do Norte, Brazil.; Laboratory of Virology, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil., de Paiva AAP; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande Do Norte, Brazil.; Laboratory of Virology, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil., Morais IC; Laboratory of Virology, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil., Nascimento YM; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande Do Norte, Brazil.; Laboratory of Virology, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil., Monteiro JD; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande Do Norte, Brazil.; Laboratory of Virology, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil., de Souto JT; Graduate Program in Parasitary Biology, Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande Do Norte, Brazil.; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande Do Norte, Brazil., Nascimento MSL; Edmond and Lily Safra International Institute of Neuroscience (ELS-IIN), Santos Dumont Institute, Macaíba, RN, Brazil., de Araújo JMG; Graduate Program in Parasitary Biology, Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande Do Norte, Brazil.; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande Do Norte, Brazil.; Laboratory of Virology, Institute of Tropical Medicine, Federal University of Rio Grande do Norte, Natal, Brazil., da Guedes PMM; Graduate Program in Parasitary Biology, Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande Do Norte, Brazil. pauloguedes@cb.ufrn.br.; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande Do Norte, Brazil. pauloguedes@cb.ufrn.br., Fernandes JV; Graduate Program in Parasitary Biology, Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande Do Norte, Brazil. veris@cb.ufrn.br.; Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande Do Norte, Brazil. veris@cb.ufrn.br.
المصدر: Medical microbiology and immunology [Med Microbiol Immunol] 2019 Dec; Vol. 208 (6), pp. 703-714. Date of Electronic Publication: 2019 Mar 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0314524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1831 (Electronic) Linking ISSN: 03008584 NLM ISO Abbreviation: Med Microbiol Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin, New York, Springer-Verlag.
مواضيع طبية MeSH: Immunity, Innate*, Immunologic Factors/*biosynthesis , Receptors, Immunologic/*biosynthesis , Zika Virus Infection/*immunology, Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Female ; Gene Expression Profiling ; Humans ; Male ; Middle Aged ; Real-Time Polymerase Chain Reaction ; Viral Load ; Zika Virus/isolation & purification
مستخلص: Innate immunity receptors (Toll-like receptors/TLRs and RIG-like receptors/RLRs) are important for the initial recognition of Zika virus (ZIKV), modulation of protective immune response, and IFN-α and IFN-β production. Immunological mechanisms involved in protection or pathology during ZIKV infection have not yet been determined. In this study, we evaluated the mRNA expression of innate immune receptors (TLR3, TLR7, TLR8, TLR9, melanoma differentiation-associated protein 5/MDA-5, and retinoic acid inducible gene/RIG-1), its adapter molecules (Myeloid Differentiation Primary Response Gene 88/Myd88, Toll/IL-1 Receptor Domain-Containing Adaptor-Inducing IFN-β/TRIF), and cytokines (IL-6, IL-12, TNF-α, IFN-α, IFN-β, and IFN-γ) in the acute phase of patients infected by ZIKV using real-time PCR in peripheral blood. Patients with acute ZIKV infection had high expression of TLR3, IFN-α, IFN-β, and IFN-γ when compared to healthy controls. In addition, there was a positive correlation between TLR3 expression compared to IFN-α and IFN-β. Moreover, viral load is positively correlated with TLR8, RIG-1, MDA-5, IFN-α, and IFN-β. On the other hand, patients infected by ZIKV showed reduced expression of RIG-1, TLR8, Myd88, and TNF-α molecules, which are also involved in antiviral immunity. Similar expressions of TLR7, TLR9, MDA-5, TRIF, IL-6, and IL-12 were observed between the group of patients infected with ZIKV and control subjects. Our results indicate that acute infection (up to 5 days after the onset of symptoms) by ZIKV in patients induces the high mRNA expression of TLR3 correlated to high expression of IFN-γ, IFN-α, and IFN-β, even though the high viral load is correlated to high expression of TLR8, RIG-1, MDA-5, IFN-α, and IFN-β in ZIKV patients.
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معلومات مُعتمدة: 400328/2014-3 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 404904/2016-5 Conselho Nacional de Desenvolvimento Científico e Tecnológico
فهرسة مساهمة: Keywords: Cytokines; Innate immune receptors; Patient; RIG-like receptors (RLRs); Toll-like receptors (TLRs); Zika virus
المشرفين على المادة: 0 (Immunologic Factors)
0 (Receptors, Immunologic)
تواريخ الأحداث: Date Created: 20190318 Date Completed: 20200306 Latest Revision: 20220801
رمز التحديث: 20221213
DOI: 10.1007/s00430-019-00588-8
PMID: 30879197
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1831
DOI:10.1007/s00430-019-00588-8