دورية أكاديمية
Propranolol and ascorbic acid in control of fibrodysplasia ossificans progressiva flare-ups due to accidental falls.
| العنوان: | Propranolol and ascorbic acid in control of fibrodysplasia ossificans progressiva flare-ups due to accidental falls. |
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| المؤلفون: | Palhares DB; UFMS/ Faculty of Medicine, Campo Grande, MS, Brazil., Nascimento DR; UFMS/ Faculty of Medicine, Campo Grande, MS, Brazil.; Medical Faculty of Barbacena, José Bonifácio Lafayette de Andrada Foundation, MG, Brazil., Palhares MG; UFMS/ Faculty of Medicine, Campo Grande, MS, Brazil., Lopes S; UFMS/ Faculty of Medicine, Campo Grande, MS, Brazil., de L; UFMS/ Faculty of Medicine, Campo Grande, MS, Brazil., Cristhina P; UFMS/ Faculty of Medicine, Campo Grande, MS, Brazil., Mauro J; Procter & Gamble Health Care & Global Clinical Sciences, Mason, OH, USA., Alves F; UFMG/ Department of Physiology and Biophysics, Belo Horizonte, MG, Brazil.; Centro Universitário Metodista Izabela Hendrix- IMIH, Belo Horizonte, MG, Brazil., Vieira RO; UFMG/ Department of Physiology and Biophysics, Belo Horizonte, MG, Brazil.; Centro Universitário Metodista Izabela Hendrix- IMIH, Belo Horizonte, MG, Brazil., Souza-Fagundes EM; UFMG/ Department of Physiology and Biophysics, Belo Horizonte, MG, Brazil., Underwood A; The Walsh University, Division of Mathematics and Sciences, North Canton, OH, USA., Milsted A; The Walsh University, Division of Mathematics and Sciences, North Canton, OH, USA., Augusto R; UFMG/ Department of Physiology and Biophysics, Belo Horizonte, MG, Brazil., Martins AS; UFMG/ Department of Physiology and Biophysics, Belo Horizonte, MG, Brazil. |
| المصدر: | Intractable & rare diseases research [Intractable Rare Dis Res] 2019 Feb; Vol. 8 (1), pp. 24-28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: International Advancement Center for Medicine & Health Research Co. (IACMHR Co.) Country of Publication: Japan NLM ID: 101586847 Publication Model: Print Cited Medium: Print ISSN: 2186-3644 (Print) Linking ISSN: 21863644 NLM ISO Abbreviation: Intractable Rare Dis Res Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Tokyo : International Advancement Center for Medicine & Health Research Co. (IACMHR Co.) |
| مستخلص: | Fibrodysplasia ossificans progressiva (FOP) is a rare, intractable and devastating genetic connective tissue disorder characterized by progressive ectopic ossification in the soft tissues and skeleton. Three patients, one teenage girl (P1), one male adult (P2) and one male child (P3), were studied and treated with FOPCON (combined formulation of 14 mg of propranolol and 250 mg of ascorbic acid), given three times per day. P1 started treatment in March 2012, P2 in October 2012 and P3 in July 2015. The clinical follow-up of these three patients, before initiating treatment with FOPCON, showed that FOP flare-ups used to occur frequently and that under FOPCON therapy, none of these patients had flare-ups. The striking feature of this treatment with FOPCON, is that, all three cases suffered accidental falls with documented injures until complete healing and that where major flare-ups should occur, injures or sequels, there was none. The present clinical observation shows that ascorbic acid plus the nonspecific beta blocker propranolol can be effectively useful, when administered previously and continually, in the prophylaxis of FOP flare-ups, especially for accidental falls. In this regard, FOPCON could be a prophylactic aid in cases of surgery of patients with FOP, hoping that it may benefit patients from having the severe sequels, characteristic of heterotopic bone formation. All three patients reported, to date, they no longer had flare-ups nor heterotopic ossification and showed normal scar healing. |
| References: | Arq Neuropsiquiatr. 2000 Jun;58(2A):342-7. (PMID: 10849638) Clin Exp Rheumatol. 2000 Nov-Dec;18(6):749-52. (PMID: 11138342) In Vitro Cell Dev Biol Anim. 2002 May;38(5):298-304. (PMID: 12418927) Lancet. 1964 May 16;1(7342):1080-1. (PMID: 14132613) J Pediatr (Rio J). 2001 Sep-Oct;77(5):431-4. (PMID: 14647850) Nat Genet. 2006 May;38(5):525-7. (PMID: 16642017) Expert Opin Biol Ther. 2007 May;7(5):705-12. (PMID: 17477807) Tex Heart Inst J. 2007;34(3):268-74. (PMID: 17948074) Ann Dermatol Venereol. 2008 Dec;135(12):860-2. (PMID: 19084699) Curr Genomics. 2010 Mar;11(1):52-7. (PMID: 20808524) Crit Rev Eukaryot Gene Expr. 2010;20(4):313-24. (PMID: 21395504) Nat Med. 2011 Apr;17(4):454-60. (PMID: 21460849) Orphanet J Rare Dis. 2011 Dec 01;6:80. (PMID: 22133093) Immunol Rev. 2012 Jul;248(1):188-204. (PMID: 22725962) J Neurol. 2012 Dec;259(12):2636-43. (PMID: 22752062) Bone. 2012 Oct;51(4):748-55. (PMID: 22796417) Genes Nutr. 2014 May;9(3):390. (PMID: 24604612) Bone. 2018 Apr;109:281-284. (PMID: 29241828) Elife. 2018 Sep 18;7:. (PMID: 30226468) Endocrinol Metab (Seoul). 2018 Sep;33(3):331-338. (PMID: 30229572) J Pharmacol Exp Ther. 1968 Nov;164(1):82-9. (PMID: 5722108) Am J Med. 1984 Oct 5;77(4A):119-27. (PMID: 6148890) Eur J Clin Pharmacol. 1995;48(3-4):295-7. (PMID: 7589058) J Bone Joint Surg Am. 1993 Feb;75(2):220-30. (PMID: 7678595) Calcif Tissue Int. 1997 Apr;60(4):394. (PMID: 9075640) |
| فهرسة مساهمة: | Keywords: FOPCON; Vitamin C; beta blocker; ectopic ossification |
| تواريخ الأحداث: | Date Created: 20190319 Latest Revision: 20201001 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6409115 |
| DOI: | 10.5582/irdr.2018.01095 |
| PMID: | 30881854 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2186-3644 |
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| DOI: | 10.5582/irdr.2018.01095 |