دورية أكاديمية
أعرض في EDS

Effects of 2-Aminoethyl Diphenylborinate, a Modulator of Transient Receptor Potential and Orai Channels in Subarachnoid Hemorrhage: An Experimental Study.

التفاصيل البيبلوغرافية
العنوان: Effects of 2-Aminoethyl Diphenylborinate, a Modulator of Transient Receptor Potential and Orai Channels in Subarachnoid Hemorrhage: An Experimental Study.
المؤلفون: Boyacı MG; Department of Neurosurgery, Afyonkarahisar Health Sciences University Faculty of Medicine, Afyonkarahisar, Turkey. Electronic address: mgazibyc@hotmail.com., Rakip U; Department of Neurosurgery, TCSB Niğde Ömer Halisdemir University Hospital, Niğde, Turkey., Aslan A; Department of Neurosurgery, Afyonkarahisar Health Sciences University Faculty of Medicine, Afyonkarahisar, Turkey., Koca HB; Department of Biochemistry, Afyonkarahisar Health Sciences University Faculty of Medicine, Afyonkarahisar, Turkey., Aslan E; Department of Histology and Embryology, Afyonkarahisar Health Sciences University Faculty of Medicine, Afyonkarahisar, Turkey., Korkmaz S; Department of Neurosurgery, Afyonkarahisar Health Sciences University Faculty of Medicine, Afyonkarahisar, Turkey., Yıldızhan S; Department of Neurosurgery, Afyonkarahisar Health Sciences University Faculty of Medicine, Afyonkarahisar, Turkey.
المصدر: World neurosurgery [World Neurosurg] 2019 Jul; Vol. 127, pp. e376-e388. Date of Electronic Publication: 2019 Mar 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101528275 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-8769 (Electronic) Linking ISSN: 18788750 NLM ISO Abbreviation: World Neurosurg Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York : Elsevier
مواضيع طبية MeSH: Boron Compounds/*pharmacology , Malondialdehyde/*pharmacology , Subarachnoid Hemorrhage/*drug therapy , Vasospasm, Intracranial/*drug therapy, Animals ; Apoptosis/drug effects ; Basilar Artery/drug effects ; Basilar Artery/pathology ; Disease Models, Animal ; Male ; Rats, Sprague-Dawley ; Tumor Necrosis Factor-alpha/metabolism ; Vasoconstriction/drug effects
مستخلص: Background: Cerebral vasospasm remains a serious problem affecting morbidity and mortality in patients with subarachnoid hemorrhage (SAH) during neurosurgery. We aimed to demonstrate the role of the transient receptor potential channel and other channels for Ca 2+ in the etiology of cerebral vasospasm using 2-aminoethyl diphenylborinate (2-APB) and the effective dose range of an unstudied pharmacological agent, which can limit vasospasm.
Methods: We performed an experimental study using 32 Sprague-Dawley rats divided into 4 groups: sham group (n = 8), SAH group (n = 8), 2-APB group (SAH rats intraperitoneally administered with 0.5 mg/kg 2-APB; n = 8), and 2-APB-2 group (SAH rats intraperitoneally administered with 2 mg/kg 2-APB; n = 8). The rats were sacrificed after 24 hours, and superoxide dismutase, glutathione peroxidase, malondialdehyde, tumor necrosis factor-α, and interleukin-1β in the brain tissue and serum were measured. The histopathological investigation of brain tissue included measurement of the luminal diameter and wall thickness of the basilar artery (BA), and apoptotic cells in the hippocampus were counted after caspase staining.
Results: Autologous arterial blood injection into the cisterna magna caused vasospasm in rats. 2-APB treatment increased the BA wall thickness and reduced the BA lumen diameter, inducing significant vascular changes. 2-APB also alleviated cell apoptosis at 24 hours after SAH.
Conclusion: In experimental SAH in rats, 2-APB treatment increased the BA wall thickness and reduced the BA lumen diameter, inducing significant vascular changes. 2-APB also alleviated cell apoptosis at 24 hours after SAH.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: 2-Aminoethyl diphenylborate; Ca(2+) channels; Cerebral vasospasm; Orai channels; Subarachnoid hemorrhage; TRP channels
المشرفين على المادة: 0 (2-aminoethyl diphenylborinate)
0 (Boron Compounds)
0 (Tumor Necrosis Factor-alpha)
4Y8F71G49Q (Malondialdehyde)
تواريخ الأحداث: Date Created: 20190326 Date Completed: 20200114 Latest Revision: 20200114
رمز التحديث: 20231215
DOI: 10.1016/j.wneu.2019.03.129
PMID: 30905651
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-8769
DOI:10.1016/j.wneu.2019.03.129