دورية أكاديمية
Sentinel Lymph Node Biopsy in Patients With Acral Melanoma: Analysis of 201 Cases From the Brazilian National Cancer Institute.
| العنوان: | Sentinel Lymph Node Biopsy in Patients With Acral Melanoma: Analysis of 201 Cases From the Brazilian National Cancer Institute. |
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| المؤلفون: | Nunes LF; Brazilian National Cancer Institute, Corrective Bone Tissue Section, Rio de Janeiro, Brazil., Mendes GLQ; Brazilian National Cancer Institute, Corrective Bone Tissue Section, Rio de Janeiro, Brazil., Koifman RJ; Department of Epidemiology and Quantitative Methods in Health, Oswaldo Cruz Foundation, National School of Public Health, Rio de Janeiro, Brazil. |
| المصدر: | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] [Dermatol Surg] 2019 Aug; Vol. 45 (8), pp. 1026-1034. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer Health Country of Publication: United States NLM ID: 9504371 Publication Model: Print Cited Medium: Internet ISSN: 1524-4725 (Electronic) Linking ISSN: 10760512 NLM ISO Abbreviation: Dermatol Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [Philadelphia] : Wolters Kluwer Health Original Publication: New York, NY : Elsevier Science, c1995- |
| مواضيع طبية MeSH: | Sentinel Lymph Node Biopsy*, Melanoma/*pathology , Skin Neoplasms/*pathology, Adult ; Aged ; Aged, 80 and over ; Brazil/epidemiology ; Female ; Humans ; Male ; Melanoma/epidemiology ; Middle Aged ; Neoplasm Invasiveness/pathology ; Prognosis ; Skin Neoplasms/epidemiology ; Survival Rate |
| مستخلص: | Background: Sentinel lymph node biopsy (SLNB) is the most powerful predictor of relapse-free survival (RFS) and overall survival (OS). No studies have evaluated survival of acral melanoma (AM) undergoing SLNB in Brazil. Objective: The objective of this study was to investigate the factors associated with the survival of patients with AM undergoing SLNB. Materials and Methods: Patients diagnosed with AM and submitted to SLNB were included in this study. We evaluated the epidemiologic, clinical, and histopathological data. Overall survival and RFS curves were estimated using the Kaplan-Meier method. Multivariable analyses were conducted using the Cox regression model. Results: Among the 201 patients, 117 (58.2%) were female. The median age was 64 years old. Median tumor depth was 5.0 mm. Lesions were ulcerated in 134 (66.7%). Five-year OS and RFS rates were 44.6% and 38.6%, respectively. Median follow-up time was 39 months. The factors associated with OS were Breslow thickness, ulceration, and SLNB status, and for RFS, they were Breslow thickness and SLNB status. Conclusion: This is the largest series of AM submitted to SLNB. The 5-year OS and RFS rates were low (44.6% and 38.6%, respectively), and the main prognostic factors for OS were Breslow thickness, ulceration, and the status of SLNB. |
| تواريخ الأحداث: | Date Created: 20190326 Date Completed: 20191122 Latest Revision: 20191122 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/DSS.0000000000001785 |
| PMID: | 30908362 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1524-4725 |
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| DOI: | 10.1097/DSS.0000000000001785 |