دورية أكاديمية
Use of antiosteoporotic medication in the Danish ROSE population-based screening study.
| العنوان: | Use of antiosteoporotic medication in the Danish ROSE population-based screening study. |
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| المؤلفون: | Høiberg MP; Department of Clinical Research, University of Southern Denmark, Odense, Denmark. mikkelhoiberg@gmail.com.; Department of Research, Hospital of Southern Norway, Egsveien 4, N-4604, Kristiansand, Norway. mikkelhoiberg@gmail.com., Rubin KH; OPEN - Odense Patient Data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark., Holmberg T; National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark., Rothmann MJ; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.; Department of Endocrinology, Odense University Hospital, Odense, Denmark.; Department of Rheumatology, Odense University Hospital, Odense, Denmark., Möller S; OPEN - Odense Patient Data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark., Gram J; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.; Department of Endocrinology, Hospital of Southwest Denmark, Esbjerg, Denmark., Bech M; VIVE - The Danish Center for Social Science Research, Copenhagen, Denmark., Brixen K; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Hermann AP; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.; Department of Endocrinology, Odense University Hospital, Odense, Denmark. |
| المصدر: | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2019 Jun; Vol. 30 (6), pp. 1223-1233. Date of Electronic Publication: 2019 Mar 26. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: England NLM ID: 9100105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-2965 (Electronic) Linking ISSN: 0937941X NLM ISO Abbreviation: Osteoporos Int Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London, UK : Springer International, c1990- |
| مواضيع طبية MeSH: | Bone Density Conservation Agents/*therapeutic use , Medication Adherence/*statistics & numerical data , Osteoporosis, Postmenopausal/*drug therapy , Osteoporotic Fractures/*prevention & control, Absorptiometry, Photon/methods ; Aged ; Aged, 80 and over ; Bone Density Conservation Agents/administration & dosage ; Denmark ; Drug Utilization/statistics & numerical data ; Female ; Humans ; Mass Screening/methods ; Middle Aged ; Osteoporosis, Postmenopausal/complications ; Osteoporosis, Postmenopausal/diagnostic imaging ; Osteoporotic Fractures/etiology ; Registries ; Risk Assessment/methods ; Treatment Refusal/statistics & numerical data |
| مستخلص: | Use of antiosteoporotic medication in the population-based, risk-stratified osteoporosis strategy evaluation (ROSE) screening study, comparing the use of FRAX followed by DXA with usual care, was examined. Screening increased the overall use of medication. Being recommended treatment by the hospital and higher age increased the likelihood of starting medication, but, nevertheless, a large percentage opted not to start treatment. Introduction: The aim of the study was to examine the impact on medication prescription, adherence, and persistence of osteoporotic medicine in the randomized population-based ROSE screening study for osteoporosis. Methods: The Danish ROSE study included a population-based random sample of women aged 65-81 years randomized to either a two-step screening program consisting of FRAX followed by DXA for high-risk participants or opportunistic screening for osteoporosis (usual care). This sub-study on the intention-to-treat population examined the impact of the screening program on antiosteoporotic medication redemption rates, adherence, and persistence using Danish registers. Results: A total of 30,719 of 34,229 women were treatment-naïve. Significantly more participants in the screening group started on antiosteoporotic medication, but no differences in adherence and persistence rates were found. Higher age was associated with a higher likelihood of starting medication. A low Charlson comorbidity score (= 1) was associated with higher treatment initiation but lower adherence and persistence of antiosteoporotic treatment. A total of 31.7% of participants advised to initiate treatment did not follow the advice. Conclusions: Screening for osteoporosis using FRAX followed by DXA increased the overall use of antiosteoporotic medication in the screening group without differences in adherence and persistence rates. A large percentage of participants advised to initiate treatment did nevertheless fail to do so. |
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| فهرسة مساهمة: | Keywords: Adherence; Compliance; Medication; Osteoporosis; Persistence; Population-based screening |
| المشرفين على المادة: | 0 (Bone Density Conservation Agents) |
| تواريخ الأحداث: | Date Created: 20190327 Date Completed: 20200106 Latest Revision: 20210827 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s00198-019-04934-7 |
| PMID: | 30911782 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1433-2965 |
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| DOI: | 10.1007/s00198-019-04934-7 |