دورية أكاديمية
Association between BRAF (V600E) mutation and clinicopathological features of papillary thyroid carcinoma: a Brazilian single-centre case series.
| العنوان: | Association between BRAF (V600E) mutation and clinicopathological features of papillary thyroid carcinoma: a Brazilian single-centre case series. |
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| المؤلفون: | Pessôa-Pereira D; Departamento de Biorregulação, Laboratório de Estudo da Tireoide, Instituto de Saúde e Ciência, Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil., Medeiros MFDS; Departamento de Biorregulação, Laboratório de Estudo da Tireoide, Instituto de Saúde e Ciência, Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil., Lima VMS; Departamento de Biorregulação, Laboratório de Estudo da Tireoide, Instituto de Saúde e Ciência, Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil., Silva JCD Jr; Departamento de Biorregulação, Laboratório de Estudo da Tireoide, Instituto de Saúde e Ciência, Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil., Cerqueira TLO; Departamento de Biorregulação, Laboratório de Estudo da Tireoide, Instituto de Saúde e Ciência, Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil., Silva ICD; Departamento de Anatomia Patológica e Citopatologia, Hospital São Rafael, Salvador, BA, Brasil., Fonseca LE Jr; Departamento de Anatomia Patológica e Citopatologia, Hospital São Rafael, Salvador, BA, Brasil.; Departamento de Anatomia Patológica e Medicina Legal, Faculdade de Medicina da Bahia, Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil., Sampaio LJL; Departamento de Medicina Nuclear, Hospital São Rafael, Salvador, BA, Brasil., Lima CRA; Departamento de Cirurgia de Cabeça e Pescoço, Hospital São Rafael, Salvador, BA, Brasil., Ramos HE; Departamento de Biorregulação, Laboratório de Estudo da Tireoide, Instituto de Saúde e Ciência, Universidade Federal da Bahia (UFBA), Salvador, BA, Brasil. |
| المصدر: | Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2019 Mar-Apr; Vol. 63 (2), pp. 97-106. Date of Electronic Publication: 2019 Mar 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Segmento Farma Editores Country of Publication: Brazil NLM ID: 101652058 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2359-4292 (Electronic) Linking ISSN: 23593997 NLM ISO Abbreviation: Arch Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: São Paulo, SP : Segmento Farma Editores |
| مواضيع طبية MeSH: | Mutation/*genetics , Proto-Oncogene Proteins B-raf/*genetics , Thyroid Cancer, Papillary/*genetics , Thyroid Neoplasms/*genetics, Adolescent ; Adult ; Age Factors ; Aged ; Brazil/epidemiology ; Child ; Cross-Sectional Studies ; DNA Mutational Analysis ; Female ; Hashimoto Disease/complications ; Hashimoto Disease/genetics ; Humans ; Male ; Middle Aged ; Prevalence ; Prognosis ; Retrospective Studies ; Thyroid Cancer, Papillary/complications ; Thyroid Cancer, Papillary/epidemiology ; Thyroid Neoplasms/epidemiology ; Young Adult |
| مستخلص: | Objectives: We aimed to investigate the prevalence of the BRAF (V600E) mutation in consecutive cases of papillary thyroid carcinoma (PTC) in patients diagnosed and treated at the Hospital Sao Rafael (Salvador, BA, Brazil) and evaluate its association with clinical and pathological characteristics of PTC. Subjects and Methods: We retrospectively enrolled in the study a total of 43 consecutive PTC patients who underwent total thyroidectomy. We performed DNA extraction from formalin-fixed paraffin-embedded (FFPE) tumour tissue samples. Polymerase chain reaction (PCR) and direct sequencing were used to determine BRAF (V600E) mutation status. Univariate and multivariate logistic regression analyses were employed to identify independent associations. Results: The prevalence of BRAF (V600E) mutation was 65.1% (28/43). A high frequency of older patients (p value: 0.004) was observed among the BRAF-mutated PTC group and, in contrast, a low frequency of concurrent Hashimoto's thyroiditis (HT) (p value: 0.011) was noted. Multivariate analysis confirmed that older age (OR: 1.15; 95% CI: 1.00 - 1.33; p value: 0.047) and HT (OR: 0.05; 95% CI: 0.006-0.40; p value: 0.005) were independent factors associated with BRAF (V600E) mutation. Conclusion: We found a high prevalence of BRAF (V600E) mutation in PTC cases. Older age and no concurrent HT were independently associated with BRAF (V600E) mutation. |
| التعليقات: | Comment in: Arch Endocrinol Metab. 2019 May 13;63(2):95-96. (PMID: 31090813) |
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| المشرفين على المادة: | EC 2.7.11.1 (BRAF protein, human) EC 2.7.11.1 (Proto-Oncogene Proteins B-raf) |
| تواريخ الأحداث: | Date Created: 20190328 Date Completed: 20190715 Latest Revision: 20231003 |
| رمز التحديث: | 20231003 |
| مُعرف محوري في PubMed: | PMC10522140 |
| DOI: | 10.20945/2359-3997000000120 |
| PMID: | 30916170 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2359-4292 |
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| DOI: | 10.20945/2359-3997000000120 |