دورية أكاديمية
Effects of microRNA-208a on inflammation and oxidative stress in ketamine-induced cardiotoxicity through Notch/NF-κB signal pathways by CHD9.
| العنوان: | Effects of microRNA-208a on inflammation and oxidative stress in ketamine-induced cardiotoxicity through Notch/NF-κB signal pathways by CHD9. |
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| المؤلفون: | Yuan H; Department of Pain Medicine, Nantong Hospital of Traditional Chinese Medicine, Nantong 226001, China 543038275@qq.com yuanhongjie81@foxmail.com., Du S; Department of Pain Medicine, Nantong Hospital of Traditional Chinese Medicine, Nantong 226001, China.; Department of Anesthesiology, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen 518055, China., Deng Y; Department of Pain Medicine, Nantong Hospital of Traditional Chinese Medicine, Nantong 226001, China.; Department of Anesthesiology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China 543038275@qq.com yuanhongjie81@foxmail.com., Xu X; Department of Pain Medicine, Nantong Hospital of Traditional Chinese Medicine, Nantong 226001, China., Zhang Q; Department of Anesthesiology, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen 518055, China., Wang M; Department of Anesthesiology, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen 518055, China., Wang P; Department of Anesthesiology, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen 518055, China., Su Y; Department of Anesthesiology, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen 518055, China., Liang X; Department of Anesthesiology, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen 518055, China., Sun Y; Department of Anesthesiology, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen 518055, China., An Z; Department of Pain Medicine ，Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, China. |
| المصدر: | Bioscience reports [Biosci Rep] 2019 May 17; Vol. 39 (5). Date of Electronic Publication: 2019 May 17 (Print Publication: 2019). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 8102797 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1573-4935 (Electronic) Linking ISSN: 01448463 NLM ISO Abbreviation: Biosci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Portland Press on behalf of the Biochemical Society Original Publication: London : The Biochemical Society, c1981- |
| مواضيع طبية MeSH: | Cardiotoxicity/*genetics , Inflammation/*genetics , MicroRNAs/*genetics , NF-kappa B/*genetics , Oxidative Stress/*genetics , Receptors, Notch/*genetics , Trans-Activators/*genetics, Animals ; Cell Line ; Heart/physiopathology ; Ketamine/pharmacology ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/genetics |
| مستخلص: | Background: MicroRNA can regulate gene expression, and participate in multiple vital activities, such as inflammation, oxidative stress epigenetic modification, cell proliferation, and apoptosis. It plays an important role in the genesis and development of cardiovascular disease. Objective: To assess the role of microRNA-208a in ketamine-induced cardiotoxicity. Methods: All rats were randomly selected into two groups: sham and model groups. After fixed, all rats in the model group was intraperitoneally (IP) injected with 100 mg/kg of ketamine. Heart samples were stained with HE assay. Total RNAs from serum were used to hybridize with the SurePrint G3 Rat Whole Genome GE 8×60 K Microarray G4858A platform. Results: In the rat model with ketamine-induced cardiotoxicity, microRNA-208a expression was increased. Then, over-expression of microRNA-208a increased inflammation and oxidative stress in vitro model. However, down-regulation of microRNA-208a decreased inflammation and oxidative stress in vitro model. Over-expression of microRNA-208a suppressed CHD9 and Notch1, and induced p65 protein expression in vitro model. Overexpression of CHD9 reduced the effects of microRNA-208a on inflammation and oxidative stress in heart cell through Notch/p65 signal pathways. Notch1 activation reduced the effects of microRNA-208a on inflammation and oxidative stress in heart cell through p65 signal pathways. Conclusion: MicroRNA-208a may be a potential biomarker for ketamine-induced cardiotoxicity through inflammation and oxidative stress by Notch/NF-κB signal pathways by CHD9. (© 2019 The Author(s).) |
| References: | Am J Clin Nutr. 2017 Feb;105(2):411-416. (PMID: 27974311) Mol Pain. 2017 Jan-Dec;13:1744806917706582. (PMID: 28580822) Am J Physiol Cell Physiol. 2013 Jul 15;305(2):C182-9. (PMID: 23636457) Toxicology. 2018 Aug 1;406-407:44-57. (PMID: 29800585) Biomed Pharmacother. 2016 Dec;84:1375-1382. (PMID: 27802900) Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15;307(6):L435-48. (PMID: 25085625) Can J Cardiol. 2015 May;31(5):679-90. (PMID: 25936493) Sci Transl Med. 2017 Sep 20;9(408):. (PMID: 28931657) Arch Med Res. 2016 May;47(4):275-84. (PMID: 27664487) Int Immunopharmacol. 2015 Jul;27(1):38-45. (PMID: 25937482) Cell Physiol Biochem. 2017;42(5):1907-1919. (PMID: 28873369) Eur Rev Med Pharmacol Sci. 2016 Mar;20(5):873-8. (PMID: 27010144) Int Heart J. 2018 Jul 31;59(4):829-836. (PMID: 29877301) Biomed Pharmacother. 2017 Oct;94:712-725. (PMID: 28800542) Intensive Care Med Exp. 2017 Aug 30;5(1):38. (PMID: 28856588) J Immunol. 2011 Nov 1;187(9):4809-17. (PMID: 21940680) J Surg Res. 2018 Apr;224:58-63. (PMID: 29506853) Front Pharmacol. 2017 Mar 21;8:120. (PMID: 28377715) Paediatr Respir Rev. 2017 Jun;23:40-49. (PMID: 28416135) J Mol Cell Cardiol. 2016 May;94:107-121. (PMID: 27056419) Inflammation. 2015 Feb;38(1):433-44. (PMID: 25338942) Int Heart J. 2018 May 30;59(3):580-588. (PMID: 29681568) Oxid Med Cell Longev. 2015;2015:597032. (PMID: 26137188) Am J Respir Cell Mol Biol. 2014 Feb;50(2):270-80. (PMID: 24007300) J Mol Med (Berl). 2017 Sep;95(9):935-949. (PMID: 28726085) J Appl Toxicol. 2015 Feb;35(2):173-80. (PMID: 25092230) |
| فهرسة مساهمة: | Keywords: CHD9; Notch; cardiotoxicity; ketamine; microRNA-208a; p65 |
| المشرفين على المادة: | 0 (MicroRNAs) 0 (NF-kappa B) 0 (Receptors, Notch) 0 (Trans-Activators) 690G0D6V8H (Ketamine) EC 3.6.4.12 (CHD9 protein, rat) |
| تواريخ الأحداث: | Date Created: 20190330 Date Completed: 20200610 Latest Revision: 20220301 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6522736 |
| DOI: | 10.1042/BSR20182381 |
| PMID: | 30923228 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1573-4935 |
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| DOI: | 10.1042/BSR20182381 |