دورية أكاديمية
Risk factors for multidrug-resistant tuberculosis in northwest Ethiopia: A case-control study.
| العنوان: | Risk factors for multidrug-resistant tuberculosis in northwest Ethiopia: A case-control study. |
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| المؤلفون: | Alene KA; School of Public Health, Curtin University, Bentley, WA, Australia.; Research School of Population Health, College of Health and Medicine, The Australian National University, Canberra, ACT, Australia.; Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.; Telethon Kids Institute, Perth, WA, Australia., Viney K; Research School of Population Health, College of Health and Medicine, The Australian National University, Canberra, ACT, Australia.; Department of Public Health Sciences, Centre for Global Health, Karolinska Institutet, Stockholm, Sweden., McBryde ES; Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, QLD, Australia., Gray DJ; Research School of Population Health, College of Health and Medicine, The Australian National University, Canberra, ACT, Australia., Melku M; School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia., Clements ACA; School of Public Health, Curtin University, Bentley, WA, Australia.; Telethon Kids Institute, Perth, WA, Australia. |
| المصدر: | Transboundary and emerging diseases [Transbound Emerg Dis] 2019 Jul; Vol. 66 (4), pp. 1611-1618. Date of Electronic Publication: 2019 Apr 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Verlag Country of Publication: Germany NLM ID: 101319538 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-1682 (Electronic) Linking ISSN: 18651674 NLM ISO Abbreviation: Transbound Emerg Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Blackwell Verlag |
| مواضيع طبية MeSH: | Antitubercular Agents/*pharmacology , HIV Infections/*complications , Mycobacterium tuberculosis/*isolation & purification , Tuberculosis, Multidrug-Resistant/*epidemiology, Adult ; Case-Control Studies ; Demography ; Ethiopia/epidemiology ; Female ; Hospitals ; Humans ; Isoniazid/pharmacology ; Logistic Models ; Male ; Middle Aged ; Mycobacterium tuberculosis/drug effects ; Odds Ratio ; Regression Analysis ; Rifampin/pharmacology ; Risk Factors ; Tuberculosis, Multidrug-Resistant/complications ; Tuberculosis, Multidrug-Resistant/microbiology ; Young Adult |
| مستخلص: | Ethiopia is one of 30-high burden multidrug-resistant tuberculosis (MDR-TB) countries globally. The aim of this study was to describe the characteristics of patients with MDR-TB and to investigate risk factors for MDR-TB relative to having drug-susceptible tuberculosis (TB), in northwest Ethiopia. A hospital-based, unmatched case-control study was conducted. Cases were all MDR-TB patients (i.e., resistant to at least rifampicin and isoniazid) who were confirmed by culture and drug-susceptibility testing whilst enrolled on treatment at Gondar University Hospital. Controls were all drug-susceptible tuberculosis (DS-TB) patients who were confirmed by Gene Xpert MTB/RIF at Gondar University Hospital. Univariable and multivariable logistic regression models were used for comparisons, and odds ratios with 95% confidence intervals (CI) were computed to measure the strength of association between the dependent and independent variables. A total of 452 patients (242 MDR-TB and 210 DS-TB) were included in this study. The mean age of the study participants was 33 years (SD ± 14 years). Approximately one-fifth (78, 17%) of all study participants were human immunodeficiency virus (HIV) positive; 21% (51) of cases and 13% (27) of controls. Risk factors associated with MDR-TB were a history of previous TB treatment (Adjusted Odds Ratio (AOR): 83.8; 95% CI: 40.7, 172.5), low educational status (AOR: 5.32; 95% CI: 1.43, 19.81); and ages less than 20 years (AOR: 9.01; 95% CI: 2.30, 35.25) and 21-30 years (AOR: 2.61; 95% CI: 1.02, 6.64). HIV infection was also significantly associated with MDR-TB among new TB patients (AOR: 5.55; 95% CI: 1.17, 26.20). This study shows that clinical and demographic features can be used to indicate higher risks of drug resistance in this setting. (© 2019 Blackwell Verlag GmbH.) |
| معلومات مُعتمدة: | GNT1121611 Australian National Health; GNT1121611 United Kingdom Medical Research Council |
| فهرسة مساهمة: | Keywords: Ethiopia; MDR-TB; multidrug-resistant; tuberculosis |
| المشرفين على المادة: | 0 (Antitubercular Agents) V83O1VOZ8L (Isoniazid) VJT6J7R4TR (Rifampin) |
| تواريخ الأحداث: | Date Created: 20190330 Date Completed: 20191111 Latest Revision: 20191111 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1111/tbed.13188 |
| PMID: | 30924283 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1865-1682 |
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| DOI: | 10.1111/tbed.13188 |