دورية أكاديمية
Tuning of thermoresponsive pNIPAAm hydrogels for the topical retention of controlled release ocular therapeutics.
| العنوان: | Tuning of thermoresponsive pNIPAAm hydrogels for the topical retention of controlled release ocular therapeutics. |
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| المؤلفون: | Bellotti E; Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Fedorchak MV; Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, 15219, USA., Velankar S; Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Little SR; Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, 15219, USA.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.; Department of Pharmaceutical Science, University of Pittsburgh, Pittsburgh, PA, 15213, USA. |
| المصدر: | Journal of materials chemistry. B [J Mater Chem B] 2019 Feb 28; Vol. 7 (8), pp. 1276-1283. Date of Electronic Publication: 2019 Jan 25. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101598493 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2050-750X (Print) Linking ISSN: 2050750X NLM ISO Abbreviation: J Mater Chem B |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Acrylic Resins/*chemistry , Drug Carriers/*chemistry , Hydrogels/*chemistry, Administration, Topical ; Cell Survival/drug effects ; Conjunctiva/cytology ; Drug Liberation ; Elastic Modulus ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Hydrogels/pharmacology ; Kinetics ; Ophthalmic Solutions/chemistry ; Ophthalmic Solutions/metabolism ; Transition Temperature ; Viscosity |
| مستخلص: | Low patient compliance and poor bioavailability of ophthalmic medications are the main limitations of topical eye drops. A potential solution to these disadvantages could be provided by thermoresponsive hydrogels, which could be used as the basis for a gelling eye drop for long-term release of therapeutics. We previously reported such a system capable of being retained in the lower fornix of rabbits, continuously releasing an anti-glaucoma drug for one month. Here, we sought to improve the properties of the existing gels as most relevant to patient use without altering the drug release profile. Specifically, we optimized the sol-to-gel transition temperature and de-swelling kinetics of pNIPAAm gels to avoid risk of the gelled drop reverting to liquid during cold or windy weather, and ensure quick gelation upon administration. A reduction of the gel LCST, faster gelation kinetics, and suitable viscosity for the administration as an eye drop were successfully achieved through modification of the poly(ethylene glycol) content in the water phase and its molecular weight. Our data suggest that drug release is not affected by these changes, with representative drug concentration profiles of the previous and new formulations demonstrating comparable anti-glaucoma release kinetics. Competing Interests: Conflicts of interest The authors report no conflict of interest. |
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| معلومات مُعتمدة: | P30 EY008098 United States EY NEI NIH HHS; R01 EY024039 United States EY NEI NIH HHS |
| المشرفين على المادة: | 0 (Acrylic Resins) 0 (Drug Carriers) 0 (Hydrogels) 0 (Ophthalmic Solutions) 25189-55-3 (poly-N-isopropylacrylamide) |
| تواريخ الأحداث: | Date Created: 20190402 Date Completed: 20190814 Latest Revision: 20240715 |
| رمز التحديث: | 20240715 |
| مُعرف محوري في PubMed: | PMC6437675 |
| DOI: | 10.1039/C8TB02976H |
| PMID: | 30931126 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2050-750X |
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| DOI: | 10.1039/C8TB02976H |