دورية أكاديمية
Effect of nicotine on prostacyclin formation in human endocardium in vitro.
| العنوان: | Effect of nicotine on prostacyclin formation in human endocardium in vitro. |
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| المؤلفون: | Alster P, Brandt R, Koul BL, Nowak J, Sonnenfeld T |
| المصدر: | General pharmacology [Gen Pharmacol] 1986; Vol. 17 (4), pp. 441-4. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 7602417 Publication Model: Print Cited Medium: Print ISSN: 0306-3623 (Print) Linking ISSN: 03063623 NLM ISO Abbreviation: Gen Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Exeter : Elsevier Science Original Publication: Oxford, Elmsford, N. Y., Pergamon Press. |
| مواضيع طبية MeSH: | Endocardium/*drug effects , Epoprostenol/*biosynthesis , Nicotine/*pharmacology, 6-Ketoprostaglandin F1 alpha/biosynthesis ; Arachidonic Acid ; Arachidonic Acids/metabolism ; Endocardium/metabolism ; Heart Valves/drug effects ; Heart Valves/metabolism ; Humans ; In Vitro Techniques |
| مستخلص: | The effect of nicotine on the formation of prostacyclin by human endocardium was studied in vitro. Slices of cardiac valve cusps were incubated in a saline medium and the prostacyclin-like activity generated spontaneously by the tissue specimens was assessed in terms of its capacity to inhibit ex vivo platelet aggregation. In separate experiments supernatants of valvular tissue homogenates were incubated with [14C]arachidonate. This resulted in the appearance of labelled 6-keto-prostaglandin F1 alpha in the radiochromatograms, indicating the formation of prostacyclin in the homogenates. Nicotine inhibited dose-dependently the spontaneous generation of prostacyclin-like activity (I50 approximately equal to 2 X 10(-4) M), as well as the formation of 6-keto-prostaglandin F1 alpha (I50 approximately equal to 2 X 10(-5) M), indicating an inhibitory effect of the drug on endocardial prostacyclin production. |
| المشرفين على المادة: | 0 (Arachidonic Acids) 27YG812J1I (Arachidonic Acid) 58962-34-8 (6-Ketoprostaglandin F1 alpha) 6M3C89ZY6R (Nicotine) DCR9Z582X0 (Epoprostenol) |
| تواريخ الأحداث: | Date Created: 19860101 Date Completed: 19861110 Latest Revision: 20190824 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1016/0306-3623(86)90188-6 |
| PMID: | 3093314 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0306-3623 |
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| DOI: | 10.1016/0306-3623(86)90188-6 |