دورية أكاديمية
Gabapentin and Cancer Risk: Updated Findings from Kaiser Permanente Northern California.
| العنوان: | Gabapentin and Cancer Risk: Updated Findings from Kaiser Permanente Northern California. |
|---|---|
| المؤلفون: | Friedman GD; Division of Research, Oakland, CA.; Department of Health Research and Policy, Stanford University School of Medicine, CA., Achacoso N; Division of Research, Oakland, CA., Habel LA; Division of Research, Oakland, CA. |
| المصدر: | The Permanente journal [Perm J] 2019; Vol. 23. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Permanente Press Country of Publication: United States NLM ID: 9800474 Publication Model: Print Cited Medium: Internet ISSN: 1552-5775 (Electronic) Linking ISSN: 15525767 NLM ISO Abbreviation: Perm J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Fall 2010- : Portland, OR : Permanente Press Original Publication: Portland, Or. : Kaiser Permanente, |
| مواضيع طبية MeSH: | Analgesics/*administration & dosage , Gabapentin/*administration & dosage , Neoplasms/*epidemiology, California/epidemiology ; Case-Control Studies ; Cohort Studies ; Databases, Factual ; Female ; Follow-Up Studies ; Humans ; Male ; Risk Assessment ; Sensitivity and Specificity ; United Kingdom/epidemiology |
| مستخلص: | Context: Epidemiologic analyses of gabapentin use and cancer risk in Kaiser Permanente Northern California were previously carried out in a collaborative study and independently evaluated in a UK database. Objective: To update these epidemiologic analyses with 7.5 more years of follow-up. Design: Case-control analyses using conditional logistic regression to estimate relative risk by odds ratios using the prior collaboration's criteria for identifying positive drug-cancer associations and our more stringent criteria requiring stronger association, lower p values, and evidence of dose response. New associations were reanalyzed with additional control for limited measures of smoking and alcohol use. Main Outcome Measures: Gabapentin-cancer associations. Results: No previously found associations met our stringent criteria, but cancers of the mouth/pharynx, esophagus, liver, and vagina did. All odds ratios for 3 or more and 8 or more prescriptions were moderately reduced by control for smoking and alcohol. Substantial elevations of risk of mouth/pharynx, liver, and vaginal cancers were associated with only 1 prescription dispensed. Sensitivity analyses aimed at possible confounding and other biases did not change our conclusions but did reveal a markedly increased risk of vaginal cancer in gabapentin users with epilepsy compared with users without. Conclusion: The reduced magnitude of relative risk with control for smoking and alcohol use suggests confounding by known risk factors. Biologically implausible elevated risk from just 1 prescription suggests confounding by indication. Either or both of these concerns applies to each of the 4 cancer sites associated with gabapentin use. Updated analyses show little if any evidence for carcinogenic effects of gabapentin. |
| References: | Toxicology. 1995 Apr 12;98(1-3):73-82. (PMID: 7740556) Brain. 2005 Jan;128(Pt 1):7-17. (PMID: 15574465) Pharmacoepidemiol Drug Saf. 2012 Feb;21(2):214-25. (PMID: 22144034) Cancer Causes Control. 2009 Dec;20(10):1821-35. (PMID: 19582585) N Engl J Med. 2018 Mar 15;378(11):1029-1041. (PMID: 29539283) |
| معلومات مُعتمدة: | R01 CA098838 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Analgesics) 6CW7F3G59X (Gabapentin) |
| تواريخ الأحداث: | Date Created: 20190403 Date Completed: 20190904 Latest Revision: 20200309 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6380473 |
| DOI: | 10.7812/TPP/18-040 |
| PMID: | 30939265 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1552-5775 |
|---|---|
| DOI: | 10.7812/TPP/18-040 |