دورية أكاديمية

Carotid intima-media thickness in chronic obstructive pulmonary disease and survival: A multicenter prospective study.

التفاصيل البيبلوغرافية
العنوان: Carotid intima-media thickness in chronic obstructive pulmonary disease and survival: A multicenter prospective study.
المؤلفون: Gulbas G; Department of Pulmonary Medicine, Turgut Ozal Research Center, Inonu University, Malatya, Turkey., Turan O; Department of Pulmonary Medicine, Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey., Sarioglu N; Department of Pulmonary Medicine, Balikesir University, Balikesir, Turkey., Diken OE; Department of Pulmonary Medicine, Hitit University, Corum, Turkey., Ogan N; Department of Pulmonary Medicine, Ufuk University, Ankara, Turkey., Ekbic Kadioglu E; Department of Pulmonary Medicine, Erzurum Training and Research Hospital, Erzurum, Turkey., Kurtipek E; Department of Pulmonary Medicine, Konya Training and Research Hospital, Konya, Turkey., Bozkus F; Department of Pulmonary Medicine, Sutcu Imam University, K. Maras, Turkey., Yilmaz Demirci N; Department of Pulmonary Medicine, Gazi University, Ankara, Turkey., Coskun Beyan A; Department of Pulmonary Medicine, Dokuz Eylul University, Izmir, Turkey., Mutlu LC; Department of Pulmonary Medicine, Namik Kemal University, Tekirdag, Turkey., Sahin Duyar S; Department of Pulmonary Medicine, Beypazari State Hospital, Ankara, Turkey., Deniz S; Department of Pulmonary Medicine, Didim State Hospital, Mugla, Turkey., Fazlioglu N; Department of Pulmonary Medicine, Acibadem Hospital, Kayseri, Turkey., Sengul A; Derince Training and Research Hospital, Kocaeli, Turkey., Tanriverdi H; Department of Pulmonary Medicine, Bulent Ecevit University, Zonguldak, Turkey., Okutan O; Department of Pulmonary Medicine, GATA, Training and Research Hospital, Istanbul., Turan PA; Department of Pulmonary Medicine, Menemen State Hospital, Izmir, Turkey., İnonu H; Department of Pulmonary Medicine, Gazi Osman Pasa University, Tokat, Turkey., Ortakoylu MG; Department of Pulmonary Medicine, Yedikule Training and Research Hospital, Istanbul, Turkey., Lakadamyali H; Department of Pulmonary Medicine, Baskent University, Alanya, Turkey., Kivanc T; Department of Pulmonary Medicine, Baskent University, Konya, Turkey., Atli O; Department of Pulmonary Medicine, Diyarbakir State Hospital, Diyarbakir, Turkey., Özdemir O; Egepol Hospital, Izmir, Turkey., Filiz Koşar A; Department of Pulmonary Medicine, Saglik Bilimleri University, Istanbul, Turkey., Mirici A; Department of Pulmonary Medicine, 18 Mart University, Canakkale, Turkey., Suerdem M; Department of Pulmonary Medicine, Selcuk University, Konya, Turkey.
المصدر: The clinical respiratory journal [Clin Respir J] 2019 Jun; Vol. 13 (6), pp. 391-399. Date of Electronic Publication: 2019 May 08.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: Blackwell Publishing Country of Publication: England NLM ID: 101315570 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-699X (Electronic) Linking ISSN: 17526981 NLM ISO Abbreviation: Clin Respir J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Blackwell Publishing
مواضيع طبية MeSH: Atherosclerosis/*diagnostic imaging , Pulmonary Disease, Chronic Obstructive/*mortality, Aged ; Atherosclerosis/etiology ; Atherosclerosis/mortality ; Carotid Intima-Media Thickness ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/diagnostic imaging ; Risk Assessment ; Survival Analysis
مستخلص: Introduction: Chronic obstructive pulmonary disease (COPD) is associated with increased cardiovascular morbidity and mortality. Carotid intima-media thickness (CIMT) is a noninvasive method assessing atherosclerosis.
Objective: It was aimed to determine relationship and survival between COPD and CIMT.
Methods: CIMT was measured using Doppler ultrasound (USG) in 668 stable COPD patients at 24 centers. Patients were followed-up for 2 years.
Results: There were 610 patients who completed the study. There were 200 patients CIMT with <0.78 mm (group 1), and 410 with CIMT ≥ 0.78 mm (group 2). There was a significant difference at the parameters of age, gender, smoking load, biomass exposure, GOLD groups and degree of airway obstruction (FEV1) between groups 1 and 2. Our results revealed positive correlations between mean CIMT and age, smoking load (pack-years), biomass exposure (years), exacerbation rate (last year), duration of hypertension (years) and cholesterol level; negative correlations between CIMT and FEV 1 (P < 0.05). According to logistic regression model, compared with group A, risk of CIMT increase was 2.2-fold in group B, 9.7-fold in group C and 4.4-fold in group D (P < 0.05). Risk of CIMT increase was also related with cholesterol level (P < 0.05). Compared with infrequent exacerbation, it was 2.8-fold in the patients with frequent exacerbation (P < 0.05). The mean survival time was slightly higher in group 1, but not significant (23.9 vs 21.8 months) (P > 0.05).
Conclusion: This study is the first regarding CIMT with combined GOLD assessment groups. It has revealed important findings supporting the increase in atherosclerosis risk in COPD patients. We recommend Doppler USG of the carotid artery in COPD patients at severe stages.
(© 2019 John Wiley & Sons Ltd.)
فهرسة مساهمة: Keywords: COPD; carotid intima-media; exacerbation; survival
تواريخ الأحداث: Date Created: 20190404 Date Completed: 20200107 Latest Revision: 20200107
رمز التحديث: 20240628
DOI: 10.1111/crj.13024
PMID: 30942958
قاعدة البيانات: MEDLINE
الوصف
تدمد:1752-699X
DOI:10.1111/crj.13024