دورية أكاديمية
أعرض في EDS

The Notch signaling pathway controls CD8+ T cell differentiation independently of the classical effector HES1.

التفاصيل البيبلوغرافية
العنوان: The Notch signaling pathway controls CD8+ T cell differentiation independently of the classical effector HES1.
المؤلفون: De Sousa DM; Maisonneuve-Rosemont Hospital Research Center, Montréal, Québec, Canada.; Département de microbiologie, infectiologie et immunologie, Université de Montréal, Montréal, Québec, Canada., Duval F; Maisonneuve-Rosemont Hospital Research Center, Montréal, Québec, Canada.; Département de microbiologie, infectiologie et immunologie, Université de Montréal, Montréal, Québec, Canada., Daudelin JF; Maisonneuve-Rosemont Hospital Research Center, Montréal, Québec, Canada., Boulet S; Maisonneuve-Rosemont Hospital Research Center, Montréal, Québec, Canada., Labrecque N; Maisonneuve-Rosemont Hospital Research Center, Montréal, Québec, Canada.; Département de microbiologie, infectiologie et immunologie, Université de Montréal, Montréal, Québec, Canada.; Département de médecine, Université de Montréal, Montréal, Québec, Canada.
المصدر: PloS one [PLoS One] 2019 Apr 05; Vol. 14 (4), pp. e0215012. Date of Electronic Publication: 2019 Apr 05 (Print Publication: 2019).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: CD8-Positive T-Lymphocytes/*immunology , Cell Differentiation/*immunology , Receptors, Notch/*immunology , Signal Transduction/*immunology , Transcription Factor HES-1/*immunology, Animals ; CD8-Positive T-Lymphocytes/cytology ; Cell Differentiation/genetics ; Mice ; Mice, Knockout ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/immunology ; Receptors, Notch/genetics ; Signal Transduction/genetics ; Transcription Factor HES-1/genetics
مستخلص: During CD8+ T cell response, Notch signaling controls short-lived-effector-cell (SLEC) generation, but the exact mechanisms by which it does so remains unclear. The Notch signaling pathway can act as a key regulator of Akt signaling via direct transcriptional induction of Hes1, which will then repress the transcription of Pten, an inhibitor of Akt signaling. As both Notch and Akt signaling can promote effector CD8+ T cell differentiation, we asked whether Notch signaling influences SLEC differentiation via the HES1-PTEN axis. Here, we demonstrate that HES1 deficiency in murine CD8+ T cells did not impact SLEC differentiation. Moreover, we show that Pten transcriptional repression in effector CD8+ T cells is not mediated by Notch signaling although Akt activation requires Notch signaling. Therefore, HES1 is not an effector of Notch signaling during CD8+ T cell response.
Competing Interests: The authors have declared that no competing interests exist.
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معلومات مُعتمدة: PJT-14903 Canada CIHR; PJT-152988 Canada CIHR
المشرفين على المادة: 0 (Hes1 protein, mouse)
0 (Receptors, Notch)
0 (Transcription Factor HES-1)
EC 3.1.3.67 (PTEN Phosphohydrolase)
EC 3.1.3.67 (Pten protein, mouse)
تواريخ الأحداث: Date Created: 20190406 Date Completed: 20191223 Latest Revision: 20200309
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6450647
DOI: 10.1371/journal.pone.0215012
PMID: 30951556
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0215012