دورية أكاديمية
Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties.
| العنوان: | Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties. |
|---|---|
| المؤلفون: | Kong X; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Chen J; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province 430030, China; State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, China., Xie W; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Brown SM; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Cai Y; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Wu K; State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, China., Fan D; State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, China., Nie Y; State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, China., Yegnasubramanian S; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Tiedemann RL; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA., Tao Y; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Chiu Yen RW; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Topper MJ; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Zahnow CA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Easwaran H; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Rothbart SB; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA. Electronic address: scott.rothbart@vai.org., Xia L; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province 430030, China; State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, China. Electronic address: xialimin@tjh.tjmu.edu.cn., Baylin SB; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA. Electronic address: sbaylin@jhmi.edu. |
| المصدر: | Cancer cell [Cancer Cell] 2019 Apr 15; Vol. 35 (4), pp. 633-648.e7. Date of Electronic Publication: 2019 Apr 04. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, Mass. : Cell Press, c2002- |
| مواضيع طبية MeSH: | DNA Methylation* , Epigenesis, Genetic*, CCAAT-Enhancer-Binding Proteins/*metabolism , Colorectal Neoplasms/*enzymology , Ubiquitin-Protein Ligases/*metabolism, Animals ; CCAAT-Enhancer-Binding Proteins/genetics ; Caco-2 Cells ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; CpG Islands ; Female ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; HT29 Cells ; Histones/genetics ; Histones/metabolism ; Humans ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, Nude ; Mice, SCID ; Mutation ; Neoplasm Metastasis ; PHD Zinc Fingers ; Prognosis ; Time Factors ; Ubiquitin-Protein Ligases/genetics |
| مستخلص: | UHRF1 facilitates the establishment and maintenance of DNA methylation patterns in mammalian cells. The establishment domains are defined, including E3 ligase function, but the maintenance domains are poorly characterized. Here, we demonstrate that UHRF1 histone- and hemimethylated DNA binding functions, but not E3 ligase activity, maintain cancer-specific DNA methylation in human colorectal cancer (CRC) cells. Disrupting either chromatin reader activity reverses DNA hypermethylation, reactivates epigenetically silenced tumor suppressor genes (TSGs), and reduces CRC oncogenic properties. Moreover, an inverse correlation between high UHRF1 and low TSG expression tracks with CRC progression and reduced patient survival. Defining critical UHRF1 domain functions and its relationship with CRC prognosis suggests directions for, and value of, targeting this protein to develop therapeutic DNA demethylating agents. (Copyright © 2019 Elsevier Inc. All rights reserved.) |
| References: | Cell Rep. 2017 Dec 19;21(12):3390-3397. (PMID: 29262320) Genome Res. 2012 May;22(5):837-49. (PMID: 22391556) Nat Commun. 2016 Aug 24;7:12464. (PMID: 27554592) Nat Genet. 2007 Feb;39(2):232-6. (PMID: 17200670) Cancer Res. 2006 Jan 15;66(2):682-92. (PMID: 16423997) Nat Rev Genet. 2016 Sep 15;17(10):630-41. (PMID: 27629931) J Biol Chem. 2013 Jan 11;288(2):1329-39. (PMID: 23161542) J Biol Chem. 2004 Feb 13;279(7):5708-15. (PMID: 14627710) Mol Cell. 2011 Jul 22;43(2):275-284. (PMID: 21777816) Nature. 2007 Dec 6;450(7171):908-12. (PMID: 17994007) Cold Spring Harb Perspect Biol. 2016 Sep 01;8(9):. (PMID: 27194046) Bioinformatics. 2014 May 15;30(10):1363-9. (PMID: 24478339) Nature. 2012 Mar 28;483(7391):603-7. (PMID: 22460905) Nucleic Acids Res. 2018 Apr 6;46(6):3218-3231. (PMID: 29471350) Nat Genet. 2015 May;47(5):469-78. (PMID: 25822089) Cell Res. 2011 Dec;21(12):1723-39. (PMID: 22064703) J Clin Invest. 2014 Sep;124(9):3708-12. (PMID: 25061879) Nat Commun. 2013;4:1563. (PMID: 23463006) J Biol Chem. 2017 Dec 22;292(51):20947-20959. (PMID: 29074623) Cancer Cell. 2014 Feb 10;25(2):196-209. (PMID: 24486181) Oncogene. 2012 Feb 9;31(6):728-38. (PMID: 21743496) Nature. 2007 Aug 2;448(7153):553-60. (PMID: 17603471) Cancer Res. 1984 Oct;44(10):4241-53. (PMID: 6467184) Genes Dev. 2013 Jun 1;27(11):1288-98. (PMID: 23752590) Elife. 2016 Sep 06;5:. (PMID: 27595565) Cancer Cell. 2017 Sep 11;32(3):360-376.e6. (PMID: 28898697) Cancer Cell. 2012 May 15;21(5):655-67. (PMID: 22624715) Oncotarget. 2014 Feb 15;5(3):587-98. (PMID: 24583822) Cell Discov. 2016 Apr 12;2:16007. (PMID: 27462454) N Engl J Med. 2012 Aug 16;367(7):647-57. (PMID: 22894577) Nature. 2013 Oct 10;502(7470):249-53. (PMID: 24013172) PLoS Comput Biol. 2013;9(3):e1002968. (PMID: 23526891) Hepatology. 2008 Aug;48(2):508-18. (PMID: 18666234) PLoS Genet. 2017 Oct 4;13(10):e1007042. (PMID: 28976982) Hepatology. 2019 Feb;69(2):587-603. (PMID: 30014490) Mol Cell Biol. 2004 Mar;24(6):2526-35. (PMID: 14993289) Oncogene. 2008 Mar 27;27(14):2027-34. (PMID: 17934522) Mol Cell. 2018 Nov 15;72(4):753-765.e6. (PMID: 30392931) Cell. 2017 Nov 30;171(6):1284-1300.e21. (PMID: 29195073) Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12950-5. (PMID: 22837395) Cell. 2015 Aug 27;162(5):961-73. (PMID: 26317465) Nat Struct Mol Biol. 2012 Nov;19(11):1155-60. (PMID: 23022729) Cell. 2013 Mar 28;153(1):38-55. (PMID: 23540689) Nature. 2012 Jul 18;487(7407):330-7. (PMID: 22810696) Genome Res. 2017 Apr;27(4):533-544. (PMID: 28232479) Science. 2012 Feb 10;335(6069):709-12. (PMID: 22323818) Nature. 2008 Oct 9;455(7214):826-9. (PMID: 18772888) Cancer Cell. 2018 Feb 12;33(2):309-321.e5. (PMID: 29438699) PLoS One. 2014 Mar 19;9(3):e92444. (PMID: 24647355) Nat Chem Biol. 2011 Mar;7(3):182-8. (PMID: 21278739) Cancer Cell. 2017 May 8;31(5):653-668.e7. (PMID: 28486105) J Biol Chem. 2011 Jul 8;286(27):24300-11. (PMID: 21489993) SLAS Discov. 2018 Oct;23(9):930-940. (PMID: 29562800) Cancer Cell. 2014 Oct 13;26(4):577-90. (PMID: 25263941) Cancer Res. 2016 Mar 15;76(6):1348-53. (PMID: 26719541) Mol Cell. 2018 Nov 15;72(4):739-752.e9. (PMID: 30392929) Nat Clin Pract Oncol. 2005 Dec;2 Suppl 1:S24-9. (PMID: 16341237) Cell Death Dis. 2014 Oct 23;5:e1493. (PMID: 25341047) Science. 2007 Sep 21;317(5845):1760-4. (PMID: 17673620) Genome Biol. 2015 Jun 02;16:115. (PMID: 26032981) Mol Cell Biol. 2003 Aug;23(16):5594-605. (PMID: 12897133) Oncotarget. 2017 Apr 24;8(31):51946-51962. (PMID: 28881702) Cell. 2015 Aug 27;162(5):974-86. (PMID: 26317466) Cell Res. 2015 Aug;25(8):911-29. (PMID: 26065575) Nature. 2008 Oct 9;455(7214):822-5. (PMID: 18772889) |
| معلومات مُعتمدة: | P30 CA006973 United States CA NCI NIH HHS; R01 ES011858 United States ES NIEHS NIH HHS; R35 GM124736 United States GM NIGMS NIH HHS; T32 GM008752 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: UHRF1; colorectal cancer prognosis; domain functions; maintenance DNA methylation; next-generation DNA demethylating agents; oncogenic properties; tumor suppressor gene silencing |
| المشرفين على المادة: | 0 (CCAAT-Enhancer-Binding Proteins) 0 (Histones) EC 2.3.2.27 (UHRF1 protein, human) EC 2.3.2.27 (Ubiquitin-Protein Ligases) |
| تواريخ الأحداث: | Date Created: 20190409 Date Completed: 20200203 Latest Revision: 20201107 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6521721 |
| DOI: | 10.1016/j.ccell.2019.03.003 |
| PMID: | 30956060 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1878-3686 |
|---|---|
| DOI: | 10.1016/j.ccell.2019.03.003 |