دورية أكاديمية
أعرض في EDS

Treatment of infant formula with patiromer dose dependently decreases potassium concentration.

التفاصيل البيبلوغرافية
العنوان: Treatment of infant formula with patiromer dose dependently decreases potassium concentration.
المؤلفون: Paloian NJ; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI, 53792, USA. npaloian@wisc.edu., Bowman B; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI, 53792, USA., Bartosh SM; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI, 53792, USA.
المصدر: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2019 Aug; Vol. 34 (8), pp. 1395-1401. Date of Electronic Publication: 2019 Apr 08.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 8708728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-198X (Electronic) Linking ISSN: 0931041X NLM ISO Abbreviation: Pediatr Nephrol Subsets: MEDLINE
أسماء مطبوعة: Publication: Berlin : Springer International
Original Publication: Berlin : Springer International, c1987-
مواضيع طبية MeSH: Cation Exchange Resins/*pharmacology , Hyperkalemia/*prevention & control , Infant Formula/*analysis , Polymers/*pharmacology , Renal Insufficiency, Chronic/*complications, Calcium/blood ; Calcium/metabolism ; Dose-Response Relationship, Drug ; Humans ; Hyperkalemia/blood ; Hyperkalemia/etiology ; Infant ; Infant Formula/chemistry ; Potassium/analysis ; Potassium/metabolism ; Renal Insufficiency, Chronic/blood ; Time Factors
مستخلص: Background: Hyperkalemia is a potentially life-threatening complication of chronic kidney disease (CKD). Dietary potassium restriction is challenging in infants despite low-potassium formulas. Decreasing potassium in formula using patiromer, a new calcium-based cation exchange polymer may be one option to accomplish this; however, data confirming efficacy is lacking.
Methods: Varying doses of patiromer were added to prepared Similac Advance and Similac PM 60/40. Measurements of potassium, calcium, sodium, magnesium, and phosphorus were obtained at baseline and at 30 min, 60 min, and 24 h following patiromer administration.
Results: Following pre-treatment with patiromer, the potassium concentration of both formulas decreased. This effect was mild with the lowest dose but increased in a dose-dependent fashion. Treating for 60 min or 24 h did not yield substantially greater effects than treating for 30 min. Calcium levels increased in both formula groups, mostly in a dose-dependent fashion. Changes in magnesium, sodium, and phosphorus were also seen after patiromer pre-treatment.
Conclusions: Pre-treatment with patiromer decreases the potassium concentration of infant formula. Calcium levels increased after treatment as expected with the majority of ion exchange occurring in 30 min. Treatment of formula with patiromer shows promise as a unique option for managing hyperkalemia.
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فهرسة مساهمة: Keywords: Formula; Hyperkalemia; Patiromer; Potassium
المشرفين على المادة: 0 (Cation Exchange Resins)
0 (Polymers)
1FQ2RY5YHH (patiromer)
RWP5GA015D (Potassium)
SY7Q814VUP (Calcium)
تواريخ الأحداث: Date Created: 20190410 Date Completed: 20200605 Latest Revision: 20200605
رمز التحديث: 20240628
DOI: 10.1007/s00467-019-04232-8
PMID: 30963285
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-198X
DOI:10.1007/s00467-019-04232-8