دورية أكاديمية
أعرض في EDS

Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition.

التفاصيل البيبلوغرافية
العنوان: Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition.
المؤلفون: Njunge JM; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya. jnjunge@kemri-wellcome.org.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya. jnjunge@kemri-wellcome.org., Gwela A; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya., Kibinge NK; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya., Ngari M; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya., Nyamako L; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya., Nyatichi E; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya., Thitiri J; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya., Gonzales GB; Department of Gastroenterology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Inflammation Research Centre, Flemish Institute for Biotechnology, Ghent, Belgium., Bandsma RHJ; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada., Walson JL; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; Departments of Global Health, Medicine, Paediatrics and Epidemiology, University of Washington, Seattle, Washington, USA., Gitau EN; African Population and Health Research Centre, Nairobi, Kenya., Berkley JA; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.; Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
المصدر: Scientific reports [Sci Rep] 2019 Apr 12; Vol. 9 (1), pp. 5981. Date of Electronic Publication: 2019 Apr 12.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Severe Acute Malnutrition/*blood , Severe Acute Malnutrition/*mortality, Biomarkers/blood ; Case-Control Studies ; Female ; Humans ; Infant ; Male ; Patient Discharge ; Time Factors
مستخلص: High mortality after discharge from hospital following acute illness has been observed among children with Severe Acute Malnutrition (SAM). However, mechanisms that may be amenable to intervention to reduce risk are unknown. We performed a nested case-control study among HIV-uninfected children aged 2-59 months treated for complicated SAM according to WHO recommendations at four Kenyan hospitals. Blood was drawn from 1778 children when clinically judged stable before discharge from hospital. Cases were children who died within 60 days. Controls were randomly selected children who survived for one year without readmission to hospital. Untargeted proteomics, total protein, cytokines and chemokines, and leptin were assayed in plasma and corresponding biological processes determined. Among 121 cases and 120 controls, increased levels of calprotectin, von Willebrand factor, angiotensinogen, IL8, IL15, IP10, TNFα, and decreased levels of leptin, heparin cofactor 2, and serum paraoxonase were associated with mortality after adjusting for possible confounders. Acute phase responses, cellular responses to lipopolysaccharide, neutrophil responses to bacteria, and endothelial responses were enriched among cases. Among apparently clinically stable children with SAM, a sepsis-like profile is associated with subsequent death. This may be due to ongoing bacterial infection, translocated bacterial products or deranged immune response during nutritional recovery.
References: Nat Methods. 2007 Mar;4(3):207-14. (PMID: 17327847)
BMJ Open. 2018 Dec 28;8(12):e023445. (PMID: 30593550)
Lancet. 2017 Dec 17;388(10063):3027-3035. (PMID: 27839855)
Trends Immunol. 2016 Jun;37(6):386-398. (PMID: 27237815)
Electrolyte Blood Press. 2010 Dec;8(2):72-81. (PMID: 21468200)
PLoS One. 2014 Aug 25;9(8):e105017. (PMID: 25153531)
Ann Trop Paediatr. 2008 Mar;28(1):13-22. (PMID: 18318945)
Br J Surg. 1996 Sep;83(9):1288-91. (PMID: 8983631)
Acta Paediatr. 2007 Dec;96(12):1832-8. (PMID: 18001338)
Bull World Health Organ. 1995;73(4):443-8. (PMID: 7554015)
J Infect Dis. 1999 Nov;180(5):1584-9. (PMID: 10515819)
Ann Trop Paediatr. 2008 Mar;28(1):23-33. (PMID: 18318946)
Trop Med Int Health. 1998 Aug;3(8):678-86. (PMID: 9735938)
J Thromb Haemost. 2007 Nov;5(11):2284-90. (PMID: 17764538)
Nephrol Dial Transplant. 2001 Oct;16(10):1968-71. (PMID: 11572879)
Nat Biotechnol. 2014 Mar;32(3):223-6. (PMID: 24727771)
Lancet Glob Health. 2016 Jul;4(7):e464-73. (PMID: 27265353)
Arch Dis Child. 1943 Jun;18(94):96-7. (PMID: 21032253)
Nat Protoc. 2009;4(1):44-57. (PMID: 19131956)
Circulation. 2000 Aug 29;102(9):994-9. (PMID: 10961963)
Am J Clin Nutr. 2004 Jul;80(1):193-8. (PMID: 15213048)
Blood. 1995 Sep 15;86(6):2220-7. (PMID: 7545022)
EBioMedicine. 2017 Aug;22:191-199. (PMID: 28750860)
Thromb Res. 2007;120 Suppl 1:S5-9. (PMID: 17493665)
Lancet. 2013 Aug 3;382(9890):427-451. (PMID: 23746772)
J Clin Invest. 1998 Mar 1;101(5):1020-7. (PMID: 9486972)
Ann Rheum Dis. 2005 Aug;64(8):1195-8. (PMID: 15731289)
PLoS One. 2015 Sep 09;10(9):e0137095. (PMID: 26353110)
Mediators Inflamm. 2017;2017:5620314. (PMID: 28634421)
Blood. 1995 May 1;85(9):2482-9. (PMID: 7537116)
Nat Biotechnol. 2008 Dec;26(12):1367-72. (PMID: 19029910)
Curr Opin Infect Dis. 2018 Jun;31(3):231-236. (PMID: 29570495)
Nat Rev Rheumatol. 2017 Feb;13(2):100-109. (PMID: 28053336)
J Proteome Res. 2011 Apr 1;10(4):1794-805. (PMID: 21254760)
Lancet. 2013 Apr 20;381(9875):1380-1390. (PMID: 23369797)
Hypertens Res. 2016 Jul;39(7):492-500. (PMID: 26888118)
BMJ Open. 2015 Nov 25;5(11):e009449. (PMID: 26608641)
Cell Immunol. 1999 May 25;194(1):6-11. (PMID: 10357875)
PLoS Med. 2006 Dec;3(12):e500. (PMID: 17194194)
Nature. 1998 Oct 22;395(6704):763-70. (PMID: 9796811)
Blood. 2001 Dec 15;98(13):3800-8. (PMID: 11739189)
J Vet Intern Med. 2010 Jan-Feb;24(1):229-30. (PMID: 20002549)
Crit Care Resusc. 2017 Sep;19(3):205-213. (PMID: 28866970)
J Immunol. 2003 Sep 1;171(5):2602-9. (PMID: 12928412)
Lancet. 2009 Jul 11;374(9684):136-44. (PMID: 19595348)
PLoS One. 2013 Jul 17;8(7):e68699. (PMID: 23874731)
Am J Clin Nutr. 2016 Nov;104(5):1441-1449. (PMID: 27655441)
Clin Biochem Rev. 2014 Nov;35(4):213-35. (PMID: 25678727)
Clin Sci (Lond). 2000 May;98(5):531-5. (PMID: 10781383)
Paediatr Int Child Health. 2014 Dec;34 Suppl 1:S1-S29. (PMID: 25475887)
Biochimie. 2017 Jan;132:19-27. (PMID: 27771368)
PLoS One. 2013 Jun 25;8(6):e66698. (PMID: 23825556)
Blood. 1999 Jul 1;94(1):179-85. (PMID: 10381511)
J Clin Endocrinol Metab. 2014 Jun;99(6):2128-37. (PMID: 24606092)
Int J Clin Exp Pathol. 2015 Feb 01;8(2):1631-9. (PMID: 25973048)
Cytokine Growth Factor Rev. 2017 Jun;35:71-84. (PMID: 28285098)
Paediatr Perinat Epidemiol. 2017 May;31(3):233-242. (PMID: 28317139)
Ann Trop Paediatr. 2011;31(2):97-107. (PMID: 21575313)
PLoS One. 2009;4(2):e4401. (PMID: 19197365)
Bull World Health Organ. 2011 Oct 1;89(10):725-32, 732A. (PMID: 22084510)
Obes Rev. 2007 Jan;8(1):21-34. (PMID: 17212793)
N Engl J Med. 2013 Jan 31;368(5):425-35. (PMID: 23363496)
PLoS One. 2014 Jul 22;9(7):e102233. (PMID: 25050734)
Shock. 2010 Oct;34(4):327-36. (PMID: 20386500)
Biomark Med. 2016 Aug;10(8):811-8. (PMID: 27414210)
J Immunol. 2002 Apr 1;168(7):3195-204. (PMID: 11907072)
Nature. 1998 Aug 27;394(6696):897-901. (PMID: 9732873)
Clin Exp Immunol. 2003 Jul;133(1):11-9. (PMID: 12823272)
معلومات مُعتمدة: United Kingdom WT_ Wellcome Trust; MR/M007367/1 United Kingdom MRC_ Medical Research Council
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20190414 Date Completed: 20201016 Latest Revision: 20240216
رمز التحديث: 20240216
مُعرف محوري في PubMed: PMC6461700
DOI: 10.1038/s41598-019-42436-y
PMID: 30979939
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-019-42436-y