دورية أكاديمية
Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition.
العنوان: | Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition. |
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المؤلفون: | Njunge JM; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya. jnjunge@kemri-wellcome.org.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya. jnjunge@kemri-wellcome.org., Gwela A; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya., Kibinge NK; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya., Ngari M; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya., Nyamako L; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya., Nyatichi E; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya., Thitiri J; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya., Gonzales GB; Department of Gastroenterology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.; Inflammation Research Centre, Flemish Institute for Biotechnology, Ghent, Belgium., Bandsma RHJ; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada., Walson JL; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; Departments of Global Health, Medicine, Paediatrics and Epidemiology, University of Washington, Seattle, Washington, USA., Gitau EN; African Population and Health Research Centre, Nairobi, Kenya., Berkley JA; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.; Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK. |
المصدر: | Scientific reports [Sci Rep] 2019 Apr 12; Vol. 9 (1), pp. 5981. Date of Electronic Publication: 2019 Apr 12. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Severe Acute Malnutrition/*blood , Severe Acute Malnutrition/*mortality, Biomarkers/blood ; Case-Control Studies ; Female ; Humans ; Infant ; Male ; Patient Discharge ; Time Factors |
مستخلص: | High mortality after discharge from hospital following acute illness has been observed among children with Severe Acute Malnutrition (SAM). However, mechanisms that may be amenable to intervention to reduce risk are unknown. We performed a nested case-control study among HIV-uninfected children aged 2-59 months treated for complicated SAM according to WHO recommendations at four Kenyan hospitals. Blood was drawn from 1778 children when clinically judged stable before discharge from hospital. Cases were children who died within 60 days. Controls were randomly selected children who survived for one year without readmission to hospital. Untargeted proteomics, total protein, cytokines and chemokines, and leptin were assayed in plasma and corresponding biological processes determined. Among 121 cases and 120 controls, increased levels of calprotectin, von Willebrand factor, angiotensinogen, IL8, IL15, IP10, TNFα, and decreased levels of leptin, heparin cofactor 2, and serum paraoxonase were associated with mortality after adjusting for possible confounders. Acute phase responses, cellular responses to lipopolysaccharide, neutrophil responses to bacteria, and endothelial responses were enriched among cases. Among apparently clinically stable children with SAM, a sepsis-like profile is associated with subsequent death. This may be due to ongoing bacterial infection, translocated bacterial products or deranged immune response during nutritional recovery. |
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معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust; MR/M007367/1 United Kingdom MRC_ Medical Research Council |
المشرفين على المادة: | 0 (Biomarkers) |
تواريخ الأحداث: | Date Created: 20190414 Date Completed: 20201016 Latest Revision: 20240216 |
رمز التحديث: | 20240216 |
مُعرف محوري في PubMed: | PMC6461700 |
DOI: | 10.1038/s41598-019-42436-y |
PMID: | 30979939 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
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DOI: | 10.1038/s41598-019-42436-y |