دورية أكاديمية
أعرض في EDS

Crataeva tapia bark lectin (CrataBL) is a chemoattractant for endothelial cells that targets heparan sulfate and promotes in vitro angiogenesis.

التفاصيل البيبلوغرافية
العنوان: Crataeva tapia bark lectin (CrataBL) is a chemoattractant for endothelial cells that targets heparan sulfate and promotes in vitro angiogenesis.
المؤلفون: Batista FP; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil., de Aguiar RB; Department of Biophysics Federal University of São Paulo (UNIFESP), Brazil., Sumikawa JT; Department of Gynecology, Federal University of São Paulo (UNIFESP), Brazil., Lobo YA; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil., Bonturi CR; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil., Ferreira RDS; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil., Andrade SS; Department of Gynecology, Federal University of São Paulo (UNIFESP), Brazil., Guedes Paiva PM; Department of Biochemistry, Federal University of Pernambuco (UFPE), Brazil., Dos Santos Correia MT; Department of Biochemistry, Federal University of Pernambuco (UFPE), Brazil., Vicente CM; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil., Toma L; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil., Sampaio MU; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil., Paschoalin T; Department of Biophysics Federal University of São Paulo (UNIFESP), Brazil., Girão MJBC; Department of Gynecology, Federal University of São Paulo (UNIFESP), Brazil., de Moraes JZ; Department of Biophysics Federal University of São Paulo (UNIFESP), Brazil., de Paula CAA; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil., Oliva MLV; Department of Biochemistry Federal University of São Paulo (UNIFESP), Brazil. Electronic address: olivaml.bioq@epm.br.
المصدر: Biochimie [Biochimie] 2019 Nov; Vol. 166, pp. 173-183. Date of Electronic Publication: 2019 Apr 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 1264604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1638-6183 (Electronic) Linking ISSN: 03009084 NLM ISO Abbreviation: Biochimie Subsets: MEDLINE
أسماء مطبوعة: Publication: Paris : Editions Scientifiques Elsevier
Original Publication: Paris.
مواضيع طبية MeSH: Angiogenesis Inducing Agents/*pharmacology , Chondroitin/*metabolism , Heparitin Sulfate/*metabolism , Neovascularization, Physiologic/*drug effects , Plant Lectins/*pharmacology, Animals ; Capparaceae/metabolism ; Cell Movement/drug effects ; Chemotactic Factors/pharmacology ; Human Umbilical Vein Endothelial Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Wound Healing/drug effects
مستخلص: Formation of new blood vessels from preexisting ones, a process known as angiogenesis, is one of the limiting steps for success in treatment of ischemic disorders. Therefore, efforts to understanding and characterize new agents capable to stimulate neovascularization are a worldwide need. Crataeva tapia bark lectin (CrataBL) has been shown to have chemoattractant properties for endothelial cells through the stimulation of migration and invasiveness of human umbilical vein endothelial cells (HUVEC) because it is a positively charged protein with high affinity to glycosaminoglycan. In addition, CrataBL increased the production of chondroitin and heparan sulfate in endothelial cells. These findings orchestrated specific adhesion on collagen I and phosphorylation of tyrosine kinase receptors, represented by vascular endothelial growth factor receptor-2 (VEGFR-2) and fibroblast growth factor receptor (FGFR), whose downstream pathways trigger the angiogenic cascade increasing cell viability, cytoskeleton rearrangement, cell motility, and tube formation. Moreover, CrataBL inhibited the activity of matrix metalloproteases type 2 (MMP-2), a protein related to tissue remodeling. Likewise, CrataBL improved wound healing and increased the number of follicular structures in lesioned areas produced in the dorsum-cervical region of C57BL/6 mice. These outcomes altogether indicate that CrataBL is a pro-angiogenic and healing agent.
(Copyright © 2019 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.)
فهرسة مساهمة: Keywords: Angiogenesis; CrataBL; FGFR; Heparan sulfate; Tissue repair
المشرفين على المادة: 0 (Angiogenesis Inducing Agents)
0 (Chemotactic Factors)
0 (CrataBL)
0 (Plant Lectins)
9007-27-6 (Chondroitin)
9050-30-0 (Heparitin Sulfate)
تواريخ الأحداث: Date Created: 20190415 Date Completed: 20191230 Latest Revision: 20191230
رمز التحديث: 20221213
DOI: 10.1016/j.biochi.2019.04.011
PMID: 30981871
قاعدة البيانات: MEDLINE
الوصف
تدمد:1638-6183
DOI:10.1016/j.biochi.2019.04.011