دورية أكاديمية
Safety and Differential Antibody and T-Cell Responses to the Plasmodium falciparum Sporozoite Malaria Vaccine, PfSPZ Vaccine, by Age in Tanzanian Adults, Adolescents, Children, and Infants.
| العنوان: | Safety and Differential Antibody and T-Cell Responses to the Plasmodium falciparum Sporozoite Malaria Vaccine, PfSPZ Vaccine, by Age in Tanzanian Adults, Adolescents, Children, and Infants. |
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| المؤلفون: | Jongo SA; Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania., Church LWP; Sanaria, Inc., Rockville, Maryland., Mtoro AT; Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania., Chakravarty S; Sanaria, Inc., Rockville, Maryland., Ruben AJ; Sanaria, Inc., Rockville, Maryland., Swanson PA; Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland., Kassim KR; Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania., Mpina M; University of Basel, Basel, Switzerland.; Swiss Tropical and Public Health Institute, Basel, Switzerland., Tumbo AM; University of Basel, Basel, Switzerland.; Swiss Tropical and Public Health Institute, Basel, Switzerland., Milando FA; Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania., Qassim M; Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania., Juma OA; Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania., Bakari BM; Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania., Simon B; Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania., James ER; Sanaria, Inc., Rockville, Maryland., Abebe Y; Sanaria, Inc., Rockville, Maryland., Kc N; Sanaria, Inc., Rockville, Maryland., Saverino E; Sanaria, Inc., Rockville, Maryland., Gondwe L; University of Basel, Basel, Switzerland.; Swiss Tropical and Public Health Institute, Basel, Switzerland., Studer F; University of Basel, Basel, Switzerland.; Swiss Tropical and Public Health Institute, Basel, Switzerland., Fink M; University of Basel, Basel, Switzerland.; Swiss Tropical and Public Health Institute, Basel, Switzerland., Cosi G; University of Basel, Basel, Switzerland.; Swiss Tropical and Public Health Institute, Basel, Switzerland., El-Khorazaty J; The Emmes Corporation, Rockville, Maryland., Styers D; The Emmes Corporation, Rockville, Maryland., Seder RA; Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland., Schindler T; University of Basel, Basel, Switzerland.; Swiss Tropical and Public Health Institute, Basel, Switzerland., Billingsley PF; Sanaria, Inc., Rockville, Maryland., Daubenberger C; University of Basel, Basel, Switzerland.; Swiss Tropical and Public Health Institute, Basel, Switzerland., Sim BKL; Protein Potential LLC, Rockville, Maryland.; Sanaria, Inc., Rockville, Maryland., Tanner M; University of Basel, Basel, Switzerland.; Swiss Tropical and Public Health Institute, Basel, Switzerland., Richie TL; Sanaria, Inc., Rockville, Maryland., Abdulla S; Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania., Hoffman SL; Sanaria, Inc., Rockville, Maryland. |
| المصدر: | The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2019 Jun; Vol. 100 (6), pp. 1433-1444. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Print Cited Medium: Internet ISSN: 1476-1645 (Electronic) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Northbrook, IL : American Society of Tropical Medicine and Hygiene Original Publication: Baltimore. |
| مواضيع طبية MeSH: | Antibodies, Protozoan/*blood , Malaria Vaccines/*immunology , Malaria, Falciparum/*prevention & control , Plasmodium falciparum/*immunology , T-Lymphocytes/*physiology, Adolescent ; Adult ; Antibody Formation ; Child ; Child, Preschool ; Double-Blind Method ; Female ; Humans ; Infant ; Malaria Vaccines/adverse effects ; Male ; Middle Aged ; Tanzania ; Vaccines, Attenuated |
| مستخلص: | In 2016, there were more cases and deaths caused by malaria globally than in 2015. An effective vaccine would be an ideal additional tool for reducing malaria's impact. Sanaria ® PfSPZ Vaccine, composed of radiation-attenuated, aseptic, purified, cryopreserved Plasmodium falciparum (Pf) sporozoites (SPZ) has been well tolerated and safe in malaria-naïve and experienced adults in the United States and Mali and protective against controlled human malaria infection with Pf in the United States and field transmission of Pf in Mali, but had not been assessed in younger age groups. We, therefore, evaluated PfSPZ Vaccine in 93 Tanzanians aged 45 years to 6 months in a randomized, double-blind, normal saline placebo-controlled trial. There were no significant differences in adverse events between vaccinees and controls or between dosage regimens. Because all age groups received three doses of 9.0 × 10 5 PfSPZ of PfSPZ Vaccine, immune responses were compared at this dosage. Median antibody responses against Pf circumsporozoite protein and PfSPZ were highest in infants and lowest in adults. T-cell responses were highest in 6-10-year olds after one dose and 1-5-year olds after three doses; infants had no significant positive T-cell responses. The safety data were used to support initiation of trials in > 300 infants in Kenya and Equatorial Guinea. Because PfSPZ Vaccine-induced protection is thought to be mediated by T cells, the T-cell data suggest PfSPZ Vaccine may be more protective in children than in adults, whereas infants may not be immunologically mature enough to respond to the PfSPZ Vaccine immunization regimen assessed. |
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| المشرفين على المادة: | 0 (Antibodies, Protozoan) 0 (Malaria Vaccines) 0 (Vaccines, Attenuated) |
| تواريخ الأحداث: | Date Created: 20190418 Date Completed: 20200123 Latest Revision: 20210109 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6553883 |
| DOI: | 10.4269/ajtmh.18-0835 |
| PMID: | 30994090 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1476-1645 |
|---|---|
| DOI: | 10.4269/ajtmh.18-0835 |