دورية أكاديمية
أعرض في EDS

Soybean Meal-Induced Intestinal Inflammation in Zebrafish Is T Cell-Dependent and Has a Th17 Cytokine Profile.

التفاصيل البيبلوغرافية
العنوان: Soybean Meal-Induced Intestinal Inflammation in Zebrafish Is T Cell-Dependent and Has a Th17 Cytokine Profile.
المؤلفون: Coronado M; Departamento de Ciencias Biologicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile., Solis CJ; Millennium Nucleus in the Biology of Intestinal Microbiota, Santiago, Chile.; Escuela de Tecnología Médica, Facultad de Ciencias de la Salud, Universidad San Sebastian, Santiago, Chile., Hernandez PP; Macrophages and Development of Immunity, Institute Pasteur, Paris, France., Feijóo CG; Departamento de Ciencias Biologicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.; Millennium Nucleus in the Biology of Intestinal Microbiota, Santiago, Chile.
المصدر: Frontiers in immunology [Front Immunol] 2019 Apr 02; Vol. 10, pp. 610. Date of Electronic Publication: 2019 Apr 02 (Print Publication: 2019).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Animal Feed/*adverse effects , Inflammatory Bowel Diseases/*immunology , Intestinal Mucosa/*immunology , Glycine max/*adverse effects , Th17 Cells/*immunology , Zebrafish/*immunology, Animals ; Homeodomain Proteins/genetics ; Homeodomain Proteins/immunology ; Inflammatory Bowel Diseases/chemically induced ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/pathology ; Intestinal Mucosa/pathology ; Th17 Cells/pathology ; Zebrafish/genetics
مستخلص: Currently, inflammatory bowel disease (IBD) is a serious public health problem on the rise worldwide. In this work, we utilized the zebrafish to introduce a new model of intestinal inflammation triggered by food intake. Taking advantage of the translucency of the larvae and the availability of transgenic zebrafish lines with fluorescently labeled macrophages, neutrophils, or lymphocytes, we studied the behavior of these cell types in vivo during the course of inflammation. We established two feeding strategies, the first using fish that were not previously exposed to food (naïve strategy) and the second in which fish were initially exposed to normal food (developed strategy). In both strategies, we analyzed the effect of subsequent intake of a control or a soybean meal diet. Our results showed increased numbers of innate immune cells in the gut in both the naïve or developed protocols. Likewise, macrophages underwent drastic morphological changes after feeding, switching from a small and rounded contour to a larger and dendritic shape. Lymphocytes colonized the intestine as early as 5 days post fertilization and increased in numbers during the inflammatory process. Gene expression analysis indicated that lymphocytes present in the intestine correspond to T helper cells. Interestingly, control diet only induced a regulatory T cell profile in the developed model. On the contrary, soybean meal diet induced a Th17 response both in naïve and developed model. In addition, when feeding was performed in rag1 -deficient fish, intestinal inflammation was not induced indicating that inflammation induced by soybean meal is T cell-dependent.
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فهرسة مساهمة: Keywords: Th17 T cells; adaptive immunity; innate immune; intestinal inflammation; lymphocyte; macrophage; zebrafish
المشرفين على المادة: 0 (Homeodomain Proteins)
128559-51-3 (RAG-1 protein)
تواريخ الأحداث: Date Created: 20190420 Date Completed: 20200708 Latest Revision: 20231213
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6454071
DOI: 10.3389/fimmu.2019.00610
PMID: 31001250
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-3224
DOI:10.3389/fimmu.2019.00610