دورية أكاديمية
Association Between miR-155 , Its Polymorphism and Ischemia-Modified Albumin in Patients with Rheumatoid Arthritis.
| العنوان: | Association Between miR-155 , Its Polymorphism and Ischemia-Modified Albumin in Patients with Rheumatoid Arthritis. |
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| المؤلفون: | Shaker OG; 1 Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt., Abdelaleem OO; 2 Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Faiyum, Egypt., Fouad NA; 3 Department of Rheumatology and Rehabilitation, Faculty of Medicine, Fayoum University, Faiyum, Egypt., Ali AMEA; 4 Department of Medical Physiology, Faculty of Medicine, Fayoum University, Faiyum, Egypt., Ahmed TI; 5 Department of Internal Medicine, Faculty of Medicine, Fayoum University, Faiyum, Egypt., Ibrahem EG; 6 Department of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Faiyum, Egypt., Abdelghaffar NK; 7 Department of Clinical Pathology, Faculty of Medicine, Fayoum University, Faiyum, Egypt. |
| المصدر: | Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research [J Interferon Cytokine Res] 2019 Jul; Vol. 39 (7), pp. 428-437. Date of Electronic Publication: 2019 Apr 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 9507088 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7465 (Electronic) Linking ISSN: 10799907 NLM ISO Abbreviation: J Interferon Cytokine Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Larchmont, NY : Mary Ann Liebert Original Publication: New York, NY : Mary Ann Liebert, c1995- |
| مواضيع طبية MeSH: | Arthritis, Rheumatoid/*immunology , MicroRNAs/*immunology , Polymorphism, Single Nucleotide/*immunology , Serum Albumin, Human/*immunology, Adult ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/genetics ; Biomarkers/blood ; Case-Control Studies ; Female ; Humans ; Male ; MicroRNAs/blood ; MicroRNAs/genetics ; Polymorphism, Single Nucleotide/genetics |
| مستخلص: | Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease. We aimed to measure the level of miR-155 and its genetic variant rs767649 in patients with RA and to evaluate their relationship with ischemia-modified albumin (IMA). The study was performed on 79 patients with RA (group I) and 78 healthy control participants (group II). Quantitative real-time polymerase chain reaction was used to assess the expression of serum miR-155 in addition to its functional variant rs767649. IMA levels were measured by enzyme-linked immunosorbent assay. Significant overexpression of miR-155 and higher levels of IMA were detected in patients with RA compared with those in controls ( P < 0.0001). The fold change in miR-155 was significantly positively associated with IMA ( r = 0.362, P = 0.001) in patients with RA. Significant differences in the frequency of miR-155 (rs767649) genotypes and alleles were noted between patients with RA and controls. MiR-155 and IMA levels were significantly associated with the genotype distribution of miR-155 (rs767649) in patients with RA and were higher in patients with the TT genotype. MiR-155 and its functional variant rs767649 might play an important role in susceptibility to the increased risk of RA, stressing the role of miR-155 as a therapeutic target in the treatment of RA. In addition, IMA levels were increased and correlated with miR-155 and its single nucleotide polymorphism rs767649 in Egyptian patients with RA. |
| فهرسة مساهمة: | Keywords: Egyptian patients; ischemia-modified albumin; miR-155; micro-RNA; polymorphism; rheumatoid arthritis |
| المشرفين على المادة: | 0 (Biomarkers) 0 (MIRN155 microRNA, human) 0 (MicroRNAs) 0 (ischemia-modified albumin) ZIF514RVZR (Serum Albumin, Human) |
| تواريخ الأحداث: | Date Created: 20190423 Date Completed: 20200601 Latest Revision: 20200601 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1089/jir.2019.0001 |
| PMID: | 31009294 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1557-7465 |
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| DOI: | 10.1089/jir.2019.0001 |