دورية أكاديمية
CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program.
العنوان: | CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program. |
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المؤلفون: | Thaventhiran T; 1 Medical Research Council Centre for Drug Safety Science and Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom., Wong W; 1 Medical Research Council Centre for Drug Safety Science and Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom., Alghanem AF; 1 Medical Research Council Centre for Drug Safety Science and Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom., Alhumeed N; 1 Medical Research Council Centre for Drug Safety Science and Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom., Aljasir MA; 1 Medical Research Council Centre for Drug Safety Science and Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom., Ramsey S; 2 Inflammation and Remodeling, Pfizer Research Unit, Cambridge, Massachusetts., Sethu S; 1 Medical Research Council Centre for Drug Safety Science and Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom., Yeang HXA; 1 Medical Research Council Centre for Drug Safety Science and Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom., Chadwick AE; 1 Medical Research Council Centre for Drug Safety Science and Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom., Cross M; 1 Medical Research Council Centre for Drug Safety Science and Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom., Webb SD; 1 Medical Research Council Centre for Drug Safety Science and Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom., Djouhri L; 3 Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Ball C; 4 National Institute for Biological Standards and Control, Hertfordshire, United Kingdom., Stebbings R; 4 National Institute for Biological Standards and Control, Hertfordshire, United Kingdom., Sathish JG; 1 Medical Research Council Centre for Drug Safety Science and Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom. |
المصدر: | Monoclonal antibodies in immunodiagnosis and immunotherapy [Monoclon Antib Immunodiagn Immunother] 2019 Apr; Vol. 38 (2), pp. 60-69. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101590955 Publication Model: Print Cited Medium: Internet ISSN: 2167-9436 (Electronic) Linking ISSN: 21679436 NLM ISO Abbreviation: Monoclon Antib Immunodiagn Immunother |
أسماء مطبوعة: | Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc. |
مواضيع طبية MeSH: | CD28 Antigens/*immunology , CD4-Positive T-Lymphocytes/*immunology , Glycolysis/*immunology , Lipogenesis/*immunology , Lymphocyte Activation/*immunology , Neoplasms/*metabolism, Acetyl Coenzyme A/metabolism ; Antibodies, Monoclonal/immunology ; CD28 Antigens/metabolism ; Cell Proliferation ; Glucose/metabolism ; Humans ; Immunologic Memory ; Neoplasms/immunology ; Neoplasms/pathology ; Protein Kinases/metabolism ; T-Lymphocytes, Regulatory/immunology ; Tumor Cells, Cultured |
مستخلص: | CD28 superagonist (CD28SA), a therapeutic immunomodulatory monoclonal antibody triggered rapid and exaggerated activation of CD4 + effector memory T cells (T |
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معلومات مُعتمدة: | MR/L006758/1 United Kingdom MRC_ Medical Research Council |
فهرسة مساهمة: | Keywords: CD28 superagonist; CD4 effector memory T cells; glycolysis; lipogenesis; oxidative phosphorylation |
المشرفين على المادة: | 0 (Antibodies, Monoclonal) 0 (CD28 Antigens) 72-89-9 (Acetyl Coenzyme A) EC 2.7.- (Protein Kinases) EC 2.7.1.- (ATP-citrate lyase kinase) IY9XDZ35W2 (Glucose) |
تواريخ الأحداث: | Date Created: 20190423 Date Completed: 20190812 Latest Revision: 20210109 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC6634261 |
DOI: | 10.1089/mab.2018.0042 |
PMID: | 31009338 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2167-9436 |
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DOI: | 10.1089/mab.2018.0042 |