دورية أكاديمية
أعرض في EDS

Levodopa does not affect expression of reinforcement learning in older adults.

التفاصيل البيبلوغرافية
العنوان: Levodopa does not affect expression of reinforcement learning in older adults.
المؤلفون: Grogan JP; University of Bristol, Bristol, UK. john.grogan@bristol.ac.uk., Isotalus HK; University of Bristol, Bristol, UK., Howat A; University of Bristol, Bristol, UK., Irigoras Izagirre N; University of Bristol, Bristol, UK., Knight LE; University Hospitals Bristol, Bristol, UK., Coulthard EJ; University of Bristol, Bristol, UK. Elizabeth.coulthard@bristol.ac.uk.; North Bristol NHS Trust, Bristol, UK. Elizabeth.coulthard@bristol.ac.uk.
المصدر: Scientific reports [Sci Rep] 2019 Apr 23; Vol. 9 (1), pp. 6349. Date of Electronic Publication: 2019 Apr 23.
نوع المنشور: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Reinforcement, Psychology*, Learning/*drug effects , Levodopa/*pharmacology, Aged ; Bayes Theorem ; Choice Behavior/drug effects ; Female ; Humans ; Male
مستخلص: Dopamine has been implicated in learning from rewards and punishment, and in the expression of this learning. However, many studies do not fully separate retrieval and decision mechanisms from learning and consolidation. Here, we investigated the effects of levodopa (dopamine precursor) on choice performance (isolated from learning or consolidation). We gave 31 healthy older adults 150 mg of levodopa or placebo (double-blinded, randomised) 1 hour before testing them on stimuli they had learned the value of the previous day. We found that levodopa did not affect the overall accuracy of choices, nor the relative expression of positively or negatively reinforced values. This contradicts several studies and suggests that overall dopamine levels may not play a role in the choice performance for values learned through reinforcement learning in older adults.
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معلومات مُعتمدة: 097081/Z/11/Z International Wellcome Trust (Wellcome); United Kingdom MRC_ Medical Research Council
المشرفين على المادة: 46627O600J (Levodopa)
تواريخ الأحداث: Date Created: 20190425 Date Completed: 20201007 Latest Revision: 20210109
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6478852
DOI: 10.1038/s41598-019-42904-5
PMID: 31015587
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-019-42904-5