دورية أكاديمية
Neutralizing Antibodies from Convalescent Chikungunya Virus Patients Can Cross-Neutralize Mayaro and Una Viruses.
| العنوان: | Neutralizing Antibodies from Convalescent Chikungunya Virus Patients Can Cross-Neutralize Mayaro and Una Viruses. |
|---|---|
| المؤلفون: | Martins KA; Division of Medicine, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland., Gregory MK; Division of Medicine, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland., Valdez SM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland., Sprague TR; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland., Encinales L; Allied Research Society, Barranquilla, Colombia., Pacheco N; Allied Research Society, Barranquilla, Colombia., Cure C; Biomelab, Barranquilla, Colombia., Porras-Ramirez A; Universidad el Bosque, Bogota, Colombia., Rico-Mendoza A; Universidad el Bosque, Bogota, Colombia., Chang A; George Washington University, Washington, District of Columbia., Pitt ML; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland., Nasar F; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland. |
| المصدر: | The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2019 Jun; Vol. 100 (6), pp. 1541-1544. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Print Cited Medium: Internet ISSN: 1476-1645 (Electronic) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Northbrook, IL : American Society of Tropical Medicine and Hygiene Original Publication: Baltimore. |
| مواضيع طبية MeSH: | Antibodies, Neutralizing/*immunology , Antibodies, Viral/*immunology , Chikungunya virus/*immunology, Chikungunya Fever/virology ; Cross Reactions ; Humans ; Immunoglobulin G/immunology ; Immunoglobulin M/immunology ; Species Specificity |
| مستخلص: | Most alphaviruses are mosquito-borne and can cause severe disease in domesticated animals and humans. The most notable recent outbreak in the Americas was the 2014 chikungunya virus (CHIKV) outbreak affecting millions and producing disease highlighted by rash and arthralgia. Chikungunya virus is a member of the Semliki Forest (SF) serocomplex, and before its arrival in the Americas, two other member of the SF complex, Una (UNAV) and Mayaro (MAYV) viruses, were circulating in Central and South America. This study examined whether antibodies from convalescent CHIKV patients could cross-neutralize UNAV and MAYV. Considerable cross-neutralization of both viruses was observed, suggesting that exposure to CHIKV can produce antibodies that may mitigate infection with UNAV or MAYV. Understanding the impact of CHIKV exposure on population susceptibility to other emerging viruses may help predict outbreaks; moreover, identification of cross-reactive immune responses among alphaviruses may lead to the development of vaccines targeting multiple viruses. |
| References: | Clin Infect Dis. 1999 Jan;28(1):67-73. (PMID: 10028074) PLoS Negl Trop Dis. 2015 Oct 23;9(10):e0004104. (PMID: 26496497) Am J Trop Med Hyg. 1967 Nov;16(6):782-5. (PMID: 4965218) Arthritis Rheumatol. 2018 Apr;70(4):585-593. (PMID: 29266856) N Engl J Med. 2015 Mar 26;372(13):1231-9. (PMID: 25806915) Am J Trop Med Hyg. 1963 Sep;12:777-81. (PMID: 14070772) Am J Trop Med Hyg. 1957 Nov;6(6):1004-11. (PMID: 13487972) Emerg Infect Dis. 2016 Nov;22(11):2000-2002. (PMID: 27767924) Am J Trop Med Hyg. 1978 Mar;27(2 Pt 2 Suppl):372-440. (PMID: 646031) Rev Inst Med Trop Sao Paulo. 2003 Mar-Apr;45(2):109-10. (PMID: 12754579) J Clin Virol. 2016 Apr;77:66-8. (PMID: 26921736) Bull World Health Organ. 1960;22:373-80. (PMID: 14434290) Arthritis Rheumatol. 2018 Apr;70(4):578-584. (PMID: 29266783) Vaccine. 2009 Aug 6;27(36):4879-82. (PMID: 19576665) Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14622-7. (PMID: 22908261) Vaccine. 2012 Jun 29;30(31):4638-43. (PMID: 22583812) Bull World Health Organ. 1961;24:735-41. (PMID: 13737288) Am J Trop Med Hyg. 1957 Nov;6(6):1012-6. (PMID: 13487973) Vaccine. 1996 Mar;14(4):337-43. (PMID: 8744562) |
| المشرفين على المادة: | 0 (Antibodies, Neutralizing) 0 (Antibodies, Viral) 0 (Immunoglobulin G) 0 (Immunoglobulin M) |
| تواريخ الأحداث: | Date Created: 20190425 Date Completed: 20200123 Latest Revision: 20210109 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6553899 |
| DOI: | 10.4269/ajtmh.18-0756 |
| PMID: | 31017081 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1476-1645 |
|---|---|
| DOI: | 10.4269/ajtmh.18-0756 |