دورية أكاديمية
Pericyte transplantation improves skeletal muscle recovery following hindlimb immobilization.
| العنوان: | Pericyte transplantation improves skeletal muscle recovery following hindlimb immobilization. |
|---|---|
| المؤلفون: | Munroe M; Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Dvoretskiy S; Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Lopez A; Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Leong J; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Dyle MC; Departments of Internal Medicine and University of Iowa, Iowa City, Iowa, USA.; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Kong H; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois-Urbana-Champaign, Urbana, Illinois, USA., Adams CM; Departments of Internal Medicine and University of Iowa, Iowa City, Iowa, USA.; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Boppart MD; Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois-Urbana-Champaign, Urbana, Illinois, USA. |
| المصدر: | FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2019 Jun; Vol. 33 (6), pp. 7694-7706. Date of Electronic Publication: 2019 Apr 25. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : [Bethesda, Md.] : Hoboken, NJ : Federation of American Societies for Experimental Biology ; Wiley Original Publication: [Bethesda, Md.] : The Federation, [c1987- |
| مواضيع طبية MeSH: | Cell Transplantation* , Hindlimb Suspension*, Muscle, Skeletal/*physiopathology , Pericytes/*transplantation, Animals ; Capillaries/growth & development ; Gene Expression Profiling ; Male ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal/blood supply ; Muscular Atrophy/rehabilitation ; Pericytes/metabolism |
| مستخلص: | Conditions of extended bed rest and limb immobilization can initiate rapid and significant loss of skeletal muscle mass and function. Physical rehabilitation is standard practice following a period of disuse, yet mobility may be severely compromised, and recovery is commonly delayed or incomplete in special populations. Thus, a novel approach toward recovery of muscle mass is highly desired. Pericytes [neuron-glial antigen 2 (NG2) + CD31 - CD45 - (Lineage - [Lin - ]) and CD146 + Lin - ] demonstrate capacity to facilitate muscle repair, yet the ability to enhance myofiber growth following disuse is unknown. In the current study, 3-4-mo-old mice were unilaterally immobilized for 14 d (IM) or immobilized for 14 d followed by 14 d of remobilization (RE). Flow cytometry and targeted gene expression analyses were completed to assess pericyte quantity and function following IM and RE. In addition, a transplantation study was conducted to assess the impact of pericytes on recovery. Results from targeted analyses suggest minimal impact of disuse on pericyte gene expression, yet NG2 + Lin - pericyte quantity is reduced following IM ( P < 0.05). Remarkably, pericyte transplantation recovered losses in myofiber cross-sectional area and the capillary-to-fiber ratio following RE, whereas deficits remained with vehicle alone ( P = 0.01). These findings provide the first evidence that pericytes effectively rehabilitate skeletal muscle mass following disuse atrophy.-Munroe, M., Dvoretskiy, S., Lopez, A., Leong, J., Dyle, M. C., Kong, H., Adams, C. M., Boppart, M. D. Pericyte transplantation improves skeletal muscle recovery following hindlimb immobilization. |
| References: | Stem Cell Reports. 2016 Jun 14;6(6):897-913. (PMID: 27304917) Am J Physiol Cell Physiol. 2014 Jul 1;307(1):C25-38. (PMID: 24788248) Development. 2015 Apr 1;142(7):1242-53. (PMID: 25742797) Circulation. 2012 Jan 3;125(1):87-99. (PMID: 22095829) Development. 2016 Aug 15;143(16):2898-906. (PMID: 27531949) Dev Cell. 2011 Aug 16;21(2):193-215. (PMID: 21839917) Stem Cells Dev. 2013 Aug 15;22(16):2298-314. (PMID: 23517218) Biomaterials. 2003 Oct;24(22):4023-9. (PMID: 12834597) Ageing Res Rev. 2018 Nov;47:80-88. (PMID: 30031068) J Appl Physiol (1985). 2010 Dec;109(6):1628-34. (PMID: 20864557) Nature. 2018 Feb 22;554(7693):475-480. (PMID: 29443965) Am J Physiol Cell Physiol. 2018 May 1;314(5):C534-C544. (PMID: 29351404) J Cachexia Sarcopenia Muscle. 2017 Apr;8(2):267-276. (PMID: 27897408) Am J Physiol Endocrinol Metab. 2012 May 15;302(9):E1113-22. (PMID: 22338078) Acta Physiol Scand. 2000 Aug;169(4):271-6. (PMID: 10951117) Front Physiol. 2014 Mar 17;5:99. (PMID: 24672488) Oncogene. 2015 Feb 12;34(7):890-901. (PMID: 24561529) J Physiol. 2015 Sep 15;593(18):4259-73. (PMID: 26173027) J Physiol. 2010 Nov 15;588(Pt 22):4579-91. (PMID: 20876198) Front Aging Neurosci. 2014 Sep 18;6:245. (PMID: 25278877) Curr Opin Clin Nutr Metab Care. 2017 May;20(3):164-168. (PMID: 28376050) Int J Biochem Cell Biol. 2013 Oct;45(10):2200-8. (PMID: 23800384) J Nutr. 2014 Aug;144(8):1196-203. (PMID: 24919692) Exp Gerontol. 2018 Mar;103:35-46. (PMID: 29269268) Am J Physiol Heart Circ Physiol. 2013 Jan 1;304(1):H72-81. (PMID: 23280781) Exp Gerontol. 2013 Feb;48(2):154-61. (PMID: 23220118) J Clin Endocrinol Metab. 2013 Dec;98(12):4872-81. (PMID: 24108315) Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12096-100. (PMID: 7991590) Cell Stem Cell. 2017 Jan 5;20(1):56-69. (PMID: 27840022) J Appl Physiol (1985). 2009 Jun;106(6):2049-59. (PMID: 19342435) Biomaterials. 2015 Jul;58:26-34. (PMID: 25941779) Am J Physiol Cell Physiol. 2012 Oct 15;303(8):C854-61. (PMID: 22895262) Prog Polym Sci. 2012 Jan;37(1):106-126. (PMID: 22125349) J Physiol. 2013 Aug 1;591(15):3789-804. (PMID: 23732643) JAMA. 2007 Apr 25;297(16):1772-4. (PMID: 17456818) Cell Stem Cell. 2008 Sep 11;3(3):301-13. (PMID: 18786417) Stem Cells. 2013 Feb;31(2):305-16. (PMID: 23165704) Front Biosci. 2001 Jan 01;6:D45-52. (PMID: 11145925) RNA Biol. 2017 Feb;14(2):171-178. (PMID: 28010172) Skelet Muscle. 2017 Jul 10;7(1):14. (PMID: 28693603) Transl Res. 2014 Apr;163(4):296-306. (PMID: 24530608) Exp Gerontol. 2015 Apr;64:17-32. (PMID: 25681639) Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E245-61. (PMID: 24895282) Med Sci Sports Exerc. 2015 Feb;47(2):315-25. (PMID: 24905768) Development. 2011 Sep;138(17):3639-46. (PMID: 21828092) J Gerontol A Biol Sci Med Sci. 2009 Jun;64(6):618-28. (PMID: 19351696) PLoS One. 2012;7(1):e29760. (PMID: 22253772) Development. 2011 Sep;138(17):3657-66. (PMID: 21828094) J Biol Chem. 2012 Aug 10;287(33):27290-301. (PMID: 22692209) Elife. 2017 Feb 10;6:. (PMID: 28186492) Am J Physiol Cell Physiol. 2017 May 1;312(5):C638-C650. (PMID: 28274919) BMC Musculoskelet Disord. 2014 Sep 26;15:315. (PMID: 25260531) Development. 2011 Sep;138(17):3647-56. (PMID: 21828093) Cell Stem Cell. 2017 Mar 2;20(3):345-359.e5. (PMID: 28111199) Aging (Albany NY). 2016 Jan;8(1):127-46. (PMID: 26826670) J Bone Joint Surg Am. 2017 Feb 15;99(4):331-341. (PMID: 28196035) |
| معلومات مُعتمدة: | R21 NS104293 United States NS NINDS NIH HHS; R01 AG060637 United States AG NIA NIH HHS; R21 HL131469 United States HL NHLBI NIH HHS; R01 AR072735 United States AR NIAMS NIH HHS; R01 AR071762 United States AR NIAMS NIH HHS; T32 EB019944 United States EB NIBIB NIH HHS |
| فهرسة مساهمة: | Keywords: capillary; disuse atrophy; muscle growth; rehabilitation; stem cells |
| تواريخ الأحداث: | Date Created: 20190426 Date Completed: 20200619 Latest Revision: 20230919 |
| رمز التحديث: | 20230919 |
| مُعرف محوري في PubMed: | PMC6529341 |
| DOI: | 10.1096/fj.201802580R |
| PMID: | 31021652 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1530-6860 |
|---|---|
| DOI: | 10.1096/fj.201802580R |