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Organic beet leaves and stalk juice attenuates HDL-C reduction induced by high-fat meal in dyslipidemic patients: A pilot randomized controlled trial.

التفاصيل البيبلوغرافية
العنوان: Organic beet leaves and stalk juice attenuates HDL-C reduction induced by high-fat meal in dyslipidemic patients: A pilot randomized controlled trial.
المؤلفون: Gomes APO; Faculty of Nutrition, Federal University of Goiás, Goiânia, Goiás, Brazil., Ferreira MA; Faculty of Nutrition, Federal University of Goiás, Goiânia, Goiás, Brazil., Camargo JM; Faculty of Nutrition, Federal University of Goiás, Goiânia, Goiás, Brazil., Araújo MO; Chemistry Institute, Federal University of Goiás, Goiânia, Goiás, Brazil., Mortoza AS; Faculty of Nutrition, Federal University of Goiás, Goiânia, Goiás, Brazil., Mota JF; Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goiás, Goiânia, Goiás, Brazil., Coelho ASG; Agronomy School, Federal University of Goiás, Goiânia, Goiás, Brazil., Capitani CD; Faculty of Applied Sciences, University of Campinas, Brazil., Coltro WKT; Chemistry Institute, Federal University of Goiás, Goiânia, Goiás, Brazil., Botelho PB; Postgraduate program of the Faculty of Nutrition, Federal University of Goiás, Goiânia, Goiás, Brazil and Faculty of Health Sciences, University of Brasília, Distrito Federal, Brazil. Electronic address: Patriciabotelho@unb.br.
المصدر: Nutrition (Burbank, Los Angeles County, Calif.) [Nutrition] 2019 Sep; Vol. 65, pp. 68-73. Date of Electronic Publication: 2019 Mar 16.
نوع المنشور: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8802712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1244 (Electronic) Linking ISSN: 08999007 NLM ISO Abbreviation: Nutrition Subsets: MEDLINE
أسماء مطبوعة: Publication: Tarrytown, NY : Elsevier Science
Original Publication: [Burbank, Calif. : Nutrition, c1987-
مواضيع طبية MeSH: Dietary Supplements* , Fruit and Vegetable Juices*, Beta vulgaris/*chemistry , Cholesterol, HDL/*blood , Dyslipidemias/*blood , Plant Leaves/*chemistry , Polyphenols/*administration & dosage, Adult ; Cross-Over Studies ; Diet, High-Fat/adverse effects ; Double-Blind Method ; Dyslipidemias/etiology ; Dyslipidemias/therapy ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Young Adult
مستخلص: Objectives: Beet leaves and stalks are rich in polyphenols; however, their effect on risk factors for cardiovascular disease in humans, to our knowledge, has not yet been investigated. The aim of this study was to analyze the acute effect of beet leaves and stalk juice, containing different concentrations of polyphenols, on lipemia, glycemic control, nitric oxide concentration, and blood pressure in patients with dyslipidemia after a high-fat meal.
Methods: In a randomized double-blind, placebo-controlled, crossover pilot study, patients 20 to 59 y of age with dyslipidemia were fed a single high-fat meal supplemented with either a placebo or one of two organic beet leaves and stalk juices rich in polyphenols (32 or 77.5 mg EAG/100 mL) with a 1-wk washout. Thus, each group was composed of 13 patients. Blood samples were obtained at fasting and 30, 60, 120, and 180 min after intervention. Total cholesterol, high-density lipoprotein, triacylglycerols, glucose, insulin, nitrite and nitrate, and blood pressure were assessed at each time period. The high-fat meal increased triacylglycerol levels after 120 (P < 0.001) and 180 min (P < 0.001) and reduced high-density lipoprotein cholesterol after 60 min (P < 0.05). This reduction was attenuated in both groups that received BLS juices after 120 min (P = 0.005). A reduction in diastolic blood pressure within groups that received BLS juice was also observed.
Results: There was no significant difference between groups for other biomarkers.
Conclusion: The beet leaves and stalk juice attenuated the reduction of high-density lipoprotein cholesterol induced by a high-fat meal.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Beta vulgaris; Cardiovascular disease; Dyslipidemia; Polyphenols
المشرفين على المادة: 0 (Cholesterol, HDL)
0 (Polyphenols)
تواريخ الأحداث: Date Created: 20190429 Date Completed: 20200824 Latest Revision: 20200824
رمز التحديث: 20231215
DOI: 10.1016/j.nut.2019.03.004
PMID: 31029925
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-1244
DOI:10.1016/j.nut.2019.03.004