دورية أكاديمية
[Ethical dilemmas in a general practitioner's clinic due to incidental findings resulting from whole genome sequencing].
العنوان: | [Ethical dilemmas in a general practitioner's clinic due to incidental findings resulting from whole genome sequencing]. |
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عنوان ترانسليتريتد: | Genoombreed onderzoek in de spreekkamer. |
المؤلفون: | Wouters RHP; UMC Utrecht, afd. Medical Humanities, Julius Centrum.; Contact: R.H.P. Wouters (r.h.p.wouters-2@umcutrecht.nl)., Bijlsma RM; UMC Utrecht, afd. Medische Oncologie, Cancer Center., Voest EE; NKI-AvL, afd. Medische Oncologie., Bredenoord AL; UMC Utrecht, afd. Medical Humanities, Julius Centrum. |
المصدر: | Nederlands tijdschrift voor geneeskunde [Ned Tijdschr Geneeskd] 2018 Jun 15; Vol. 162. Date of Electronic Publication: 2018 Jun 15. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | Dutch; Flemish |
بيانات الدورية: | Publisher: Vereniging NTvG Country of Publication: Netherlands NLM ID: 0400770 Publication Model: Electronic Cited Medium: Internet ISSN: 1876-8784 (Electronic) Linking ISSN: 00282162 NLM ISO Abbreviation: Ned Tijdschr Geneeskd Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2017?-: Amsterdam : Vereniging NTvG Original Publication: Houten : Bohn Stafleu van Loghum |
مواضيع طبية MeSH: | Genome, Human* , Incidental Findings*, General Practice/*ethics , General Practitioners/*ethics , Practice Patterns, Physicians'/*ethics , Precision Medicine/*ethics , Whole Genome Sequencing/*ethics, Decision Making ; Family ; Genomics/ethics ; Humans ; Informed Consent/ethics ; Morals ; Patient Selection/ethics ; Social Responsibility |
مستخلص: | Whole genome sequencing (WGS) is increasingly being used in clinical practice. As a result, various healthcare professionals now encounter ethical dilemmas that were formerly confined within the genetics clinic. In addition to autonomy and well-being of both patients and their family members, which need to be balanced carefully, a societal perspective is also vital to ensure the ethically sound introduction of whole genome sequencing into daily practice. Important choices to be made are: who is eligible for whole genome sequencing; how can informed consent be sensibly obtained, when dealing with such vast quantities of genomic information; which type of information should be offered to patients; should professionals actively search for pathogenic mutations. The rise of WGS has an impact on the moral responsibilities incumbent on healthcare professionals and necessitates a comprehensive societal debate on the advent of personalized medicine. |
تواريخ الأحداث: | Date Created: 20190501 Date Completed: 20190923 Latest Revision: 20190923 |
رمز التحديث: | 20240628 |
PMID: | 31035742 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1876-8784 |
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