دورية أكاديمية
أعرض في EDS

Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Effects of physical exercises on inflammatory biomarkers and cardiopulmonary function in patients living with HIV: a systematic review with meta-analysis.
المؤلفون: Ibeneme SC; Department of Medical Rehabilitation, Faculty of Health Sciences, University of Nigeria, Enugu Campus, Enugu, Nigeria. sam.ibeneme@unn.edu.ng.; Department of Physiotherapy, Faculty of Health Sciences, School of Therapeutic Studies, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg, 2193, South Africa. sam.ibeneme@unn.edu.ng.; Clinical Trial Consortium University of Nigeria, Nsukka, Nigeria. sam.ibeneme@unn.edu.ng., Omeje C; Department of Medical Rehabilitation, Faculty of Health Sciences, University of Nigeria, Enugu Campus, Enugu, Nigeria., Myezwa H; Department of Physiotherapy, Faculty of Health Sciences, School of Therapeutic Studies, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg, 2193, South Africa., Ezeofor SN; Department of Radiation Medicine, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Ituku-Ozalla Campus, Enugu, Nigeria.; Clinical Trial Consortium University of Nigeria, Nsukka, Nigeria., Anieto EM; Department of Medical Rehabilitation, Faculty of Health Sciences, University of Nigeria, Enugu Campus, Enugu, Nigeria., Irem F; Department of Medical Rehabilitation, Faculty of Health Sciences, University of Nigeria, Enugu Campus, Enugu, Nigeria., Nnamani AO; Department of Radiation Medicine, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Ituku-Ozalla Campus, Enugu, Nigeria.; Clinical Trial Consortium University of Nigeria, Nsukka, Nigeria., Ezenwankwo FE; Department of Medical Rehabilitation, Faculty of Health Sciences, University of Nigeria, Enugu Campus, Enugu, Nigeria., Ibeneme GC; Department of Nursing Sciences, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria.
المصدر: BMC infectious diseases [BMC Infect Dis] 2019 Apr 29; Vol. 19 (1), pp. 359. Date of Electronic Publication: 2019 Apr 29.
نوع المنشور: Journal Article; Meta-Analysis; Systematic Review
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Exercise*, Biomarkers/*metabolism , HIV Infections/*diagnosis , Lung/*metabolism , Myocardium/*metabolism, C-Reactive Protein/metabolism ; Cytokines/metabolism ; HIV Infections/immunology ; Humans
مستخلص: Background: Pro-inflammatory cytokines expressed in human immune deficiency virus (HIV) infection, may induce oxidative stress likely to compromise the patency of the airways or damage the lung tissues/cardiac function. However, physical (aerobic and/or resistance) exercise-induced release of heat shock protein, immune function alteration or reduced tissue hypoxia, have been highlighted as possible mechanisms by which increasing physical activity may reduce plasma pro-inflammatory cytokines in uninfected individuals and should be appraised in the literature for evidence of similar benefits in people living with HIV (PLWH). Therefore, we evaluated the effects of physical exercises on 1) inflammatory biomarkers and 2) cardiopulmonary function (VO 2 Max) in PLWH.
Method: A systematic review was conducted using the Cochrane Collaboration protocol. Searching databases, up to January 2018. Only randomized control trials investigating the effects of either aerobic or resistance or a combination of both exercise types with a control/other intervention(s) for a period of at least 4 weeks among adults living with HIV, were included. Two independent reviewers determined the eligibility of the studies. Data were extracted and risk of bias (ROB) was assessed with the Cochrane Collaboration ROB tool. Meta-analyses were conducted with random effect models using the Review Manager (RevMan) computer software.
Result: Twenty-three studies met inclusion criteria (n = 1073 participants at study completion) comprising male and female with age range 18-65 years. Three meta-analyses across three sub-groups comparisons were performed. The result showed no significant change in biomarkers of inflammation (IL-6 and IL-1β) unlike a significant (Z = 3.80, p < 0.0001) improvement in VO 2 Max. Overall, the GRADE evidence for this review was of moderate quality.
Conclusion: There was evidence that engaging in either aerobic or resistance exercise, or a combination of both exercises, two to five times per week can lead to a significant improvement in cardiopulmonary function but not biomarkers of inflammation (IL-6 and IL-1β). However, this should not be interpreted as "No evidence of effect" because the individual trial studies did not attain sufficient power to detect treatment effects. The moderate grade evidence for this review suggests that further research may likely have an important impact on our confidence in the estimate of effects and may change the estimate.
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فهرسة مساهمة: Keywords: Aerobic exercises; Cardiopulmonary function; Highly active antiretroviral therapy; Human immunodeficiency virus; Inflammatory biomarkers; Meta-analysis; Patients living with HIV; Physical exercises; Quality of life; Resistance exercises; Systematic review
المشرفين على المادة: 0 (Biomarkers)
0 (Cytokines)
9007-41-4 (C-Reactive Protein)
تواريخ الأحداث: Date Created: 20190501 Date Completed: 20190618 Latest Revision: 20240716
رمز التحديث: 20240716
مُعرف محوري في PubMed: PMC6489236
DOI: 10.1186/s12879-019-3960-0
PMID: 31035959
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2334
DOI:10.1186/s12879-019-3960-0