دورية أكاديمية
أعرض في EDS

Changes in the Anterior Lamina Cribrosa Morphology with Glaucoma Severity.

التفاصيل البيبلوغرافية
العنوان: Changes in the Anterior Lamina Cribrosa Morphology with Glaucoma Severity.
المؤلفون: Tan NYQ; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Tham YC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Thakku SG; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore., Wang X; Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore., Baskaran M; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore., Tan MCL; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Vision Performance Centre, Singapore Armed Forces, Singapore, Singapore., Mari JM; GePaSud, Université de la Polynésie Française, Tahiti, French Polynesia., Strouthidis NG; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK., Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Girard MJA; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. chingyu.cheng@duke-nus.edu.sg.; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. chingyu.cheng@duke-nus.edu.sg.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. chingyu.cheng@duke-nus.edu.sg.
المصدر: Scientific reports [Sci Rep] 2019 Apr 29; Vol. 9 (1), pp. 6612. Date of Electronic Publication: 2019 Apr 29.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Glaucoma/*pathology, Aged ; Cross-Sectional Studies ; Female ; Glaucoma/diagnostic imaging ; Glaucoma/physiopathology ; Glaucoma, Open-Angle/diagnostic imaging ; Glaucoma, Open-Angle/pathology ; Glaucoma, Open-Angle/physiopathology ; Humans ; Intraocular Pressure/physiology ; Linear Models ; Male ; Middle Aged ; Optic Disk/diagnostic imaging ; Optic Disk/pathology ; Optic Disk/physiopathology ; Retinal Ganglion Cells/physiology ; Tomography, Optical Coherence
مستخلص: This study was designed to evaluate if primary open angle glaucoma (POAG) and its severity are associated with the shape of the lamina cribrosa (LC) as measured by a global shape index (LC-GSI), or other indices of LC curvature or depth. Optical coherence tomography (OCT) scans of the optic nerve head (OHN) were obtained from subjects with POAG (n = 99) and non-glaucomatous controls (n = 76). ONH structures were delineated, the anterior LC morphology reconstructed in 3D, and the LC-GSI calculated (more negative values denote greater posterior concavity). Anterior LC depth and 2D-curvature were also measured. Severity of glaucoma was defined by the extent of visual field loss, based on the Hodapp-Parrish-Anderson grading. Linear regression analyses compared LC characteristics between controls, mild-moderate, and advanced POAG groups. After adjusting for age, gender, ethnicity, intraocular pressure, axial length and corneal curvature, the LC-GSI was most negative in the advanced POAG group (mean [standard error] = -0.34 [0.05]), followed by the mild-moderate POAG group (-0.31 [0.02]) and then controls (-0.23 [0.02], P Trend  = 0.01). There was also a significant trend of increasing LC depth and greater LC horizontal curvature with increasing severity of glaucoma (P Trend  = 0.04 and 0.02, respectively). Therefore, with more severe glaucoma, the LC-GSI was increasingly more negative, and the anterior LC depth and curvature greater. These observations collectively correspond to greater cupping of the ONH at the level of the LC. As the LC-GSI describes the 3D anterior LC morphology, its potential usage may be complementary to existing ONH parameters measured on OCT.
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معلومات مُعتمدة: United Kingdom DH_ Department of Health
تواريخ الأحداث: Date Created: 20190501 Date Completed: 20201019 Latest Revision: 20210109
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6488637
DOI: 10.1038/s41598-019-42649-1
PMID: 31036869
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-019-42649-1