دورية أكاديمية
Changes in the Anterior Lamina Cribrosa Morphology with Glaucoma Severity.
العنوان: | Changes in the Anterior Lamina Cribrosa Morphology with Glaucoma Severity. |
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المؤلفون: | Tan NYQ; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Tham YC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Thakku SG; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore., Wang X; Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore., Baskaran M; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore., Tan MCL; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Vision Performance Centre, Singapore Armed Forces, Singapore, Singapore., Mari JM; GePaSud, Université de la Polynésie Française, Tahiti, French Polynesia., Strouthidis NG; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK., Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Girard MJA; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. chingyu.cheng@duke-nus.edu.sg.; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. chingyu.cheng@duke-nus.edu.sg.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. chingyu.cheng@duke-nus.edu.sg. |
المصدر: | Scientific reports [Sci Rep] 2019 Apr 29; Vol. 9 (1), pp. 6612. Date of Electronic Publication: 2019 Apr 29. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Glaucoma/*pathology, Aged ; Cross-Sectional Studies ; Female ; Glaucoma/diagnostic imaging ; Glaucoma/physiopathology ; Glaucoma, Open-Angle/diagnostic imaging ; Glaucoma, Open-Angle/pathology ; Glaucoma, Open-Angle/physiopathology ; Humans ; Intraocular Pressure/physiology ; Linear Models ; Male ; Middle Aged ; Optic Disk/diagnostic imaging ; Optic Disk/pathology ; Optic Disk/physiopathology ; Retinal Ganglion Cells/physiology ; Tomography, Optical Coherence |
مستخلص: | This study was designed to evaluate if primary open angle glaucoma (POAG) and its severity are associated with the shape of the lamina cribrosa (LC) as measured by a global shape index (LC-GSI), or other indices of LC curvature or depth. Optical coherence tomography (OCT) scans of the optic nerve head (OHN) were obtained from subjects with POAG (n = 99) and non-glaucomatous controls (n = 76). ONH structures were delineated, the anterior LC morphology reconstructed in 3D, and the LC-GSI calculated (more negative values denote greater posterior concavity). Anterior LC depth and 2D-curvature were also measured. Severity of glaucoma was defined by the extent of visual field loss, based on the Hodapp-Parrish-Anderson grading. Linear regression analyses compared LC characteristics between controls, mild-moderate, and advanced POAG groups. After adjusting for age, gender, ethnicity, intraocular pressure, axial length and corneal curvature, the LC-GSI was most negative in the advanced POAG group (mean [standard error] = -0.34 [0.05]), followed by the mild-moderate POAG group (-0.31 [0.02]) and then controls (-0.23 [0.02], P |
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معلومات مُعتمدة: | United Kingdom DH_ Department of Health |
تواريخ الأحداث: | Date Created: 20190501 Date Completed: 20201019 Latest Revision: 20210109 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC6488637 |
DOI: | 10.1038/s41598-019-42649-1 |
PMID: | 31036869 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
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DOI: | 10.1038/s41598-019-42649-1 |