دورية أكاديمية
أعرض في EDS

Oscillatory hyperactivity and hyperconnectivity in young APOE -ɛ4 carriers and hypoconnectivity in Alzheimer's disease.

التفاصيل البيبلوغرافية
العنوان: Oscillatory hyperactivity and hyperconnectivity in young APOE -ɛ4 carriers and hypoconnectivity in Alzheimer's disease.
المؤلفون: Koelewijn L; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom., Lancaster TM; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom.; Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom.; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom., Linden D; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom.; Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom.; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom., Dima DC; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom., Routley BC; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom., Magazzini L; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom., Barawi K; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom., Brindley L; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom., Adams R; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom., Tansey KE; Core Bioinformatics and Statistics Team, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom., Bompas A; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom., Tales A; Department of Psychology, College of Human and Health Sciences, Swansea University, Swansea, United Kingdom., Bayer A; School of Medicine, Cardiff University, Cardiff, United Kingdom., Singh K; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom.; Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom.
المصدر: ELife [Elife] 2019 Apr 30; Vol. 8. Date of Electronic Publication: 2019 Apr 30.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Genetic Predisposition to Disease*, Alzheimer Disease/*genetics , Alzheimer Disease/*metabolism , Apolipoprotein E4/*genetics , Apolipoprotein E4/*metabolism, Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/pathology ; Brain/diagnostic imaging ; Brain Mapping/methods ; Female ; Genotype ; Heterozygote ; Humans ; Image Processing, Computer-Assisted ; Machine Learning ; Magnetic Resonance Imaging ; Magnetoencephalography/methods ; Male ; Parietal Lobe ; Sensitivity and Specificity ; Young Adult
مستخلص: We studied resting-state oscillatory connectivity using magnetoencephalography in healthy young humans (N = 183) genotyped for APOE-ɛ4, the greatest genetic risk for Alzheimer's disease (AD). Connectivity across frequencies, but most prevalent in alpha/beta, was increased in APOE-ɛ4 in a set of mostly right-hemisphere connections, including lateral parietal and precuneus regions of the Default Mode Network. Similar regions also demonstrated hyperactivity, but only in gamma (40-160 Hz). In a separate study of AD patients, hypoconnectivity was seen in an extended bilateral network that partially overlapped with the hyperconnected regions seen in young APOE-ɛ4 carriers. Using machine-learning, AD patients could be distinguished from elderly controls with reasonable sensitivity and specificity, while young APOE-e4 carriers could also be distinguished from their controls with above chance performance. These results support theories of initial hyperconnectivity driving eventual profound disconnection in AD and suggest that this is present decades before the onset of AD symptomology.
Competing Interests: LK, TL, DL, DD, BR, LM, KB, LB, RA, KT, AB, AT, AB, KS No competing interests declared
(© 2019, Koelewijn et al.)
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معلومات مُعتمدة: MR/K501086/1 United Kingdom MRC_ Medical Research Council; MR/K005464/1 United Kingdom MRC_ Medical Research Council; MR/K004360/1 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust
فهرسة مساهمة: Keywords: APOE-ɛ4; Alzheimer's disease; functional connectivity; human; neural oscillations; neuroscience; parietal cortex
المشرفين على المادة: 0 (Apolipoprotein E4)
تواريخ الأحداث: Date Created: 20190501 Date Completed: 20200304 Latest Revision: 20240413
رمز التحديث: 20240413
مُعرف محوري في PubMed: PMC6491037
DOI: 10.7554/eLife.36011
PMID: 31038453
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.36011