دورية أكاديمية
أعرض في EDS

Swimming training potentiates the recovery of femoral neck strength in young diabetic rats under insulin therapy.

التفاصيل البيبلوغرافية
العنوان: Swimming training potentiates the recovery of femoral neck strength in young diabetic rats under insulin therapy.
المؤلفون: Gomes GJ; Departamento de Educacao Fisica, Universidade Federal de Vicosa, Vicosa, MG, BR.; Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, BR., Carlo RJD; Departamento de Veterinaria, Universidade Federal de Vicosa, Vicosa, MG, BR., Silva MFD; Instituto Federal de Minas Gerais, Sao Joao Evangelista, MG, BR., Cunha DNQD; Departamento de Educacao Fisica, Universidade Federal de Vicosa, Vicosa, MG, BR., Silva ED; Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, BR., Silva KAD; Departamento de Educacao Fisica, Universidade Federal de Vicosa, Vicosa, MG, BR., Carneiro-Junior MA; Departamento de Educacao Fisica, Universidade Federal de Vicosa, Vicosa, MG, BR., Prímola-Gomes TN; Departamento de Educacao Fisica, Universidade Federal de Vicosa, Vicosa, MG, BR., Natali AJ; Departamento de Educacao Fisica, Universidade Federal de Vicosa, Vicosa, MG, BR.
المصدر: Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2019; Vol. 74, pp. e829. Date of Electronic Publication: 2019 Apr 29.
نوع المنشور: Evaluation Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101244734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1980-5322 (Electronic) Linking ISSN: 18075932 NLM ISO Abbreviation: Clinics (Sao Paulo) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2022- : [New York] : Elsevier
Original Publication: São Paulo, SP : Hospital das Clínicas, Faculty of Medicine, University of São Paulo, [2005]-
مواضيع طبية MeSH: Diabetes Mellitus, Experimental/*drug therapy , Diabetes Mellitus, Experimental/*physiopathology , Exercise Therapy/*methods , Femur Neck/*physiopathology , Hypoglycemic Agents/*therapeutic use , Insulin/*therapeutic use , Swimming/*physiology, Animals ; Blood Glucose/analysis ; Body Weight/physiology ; Cancellous Bone/physiopathology ; Collagen/analysis ; Fractures, Bone/physiopathology ; Fractures, Bone/prevention & control ; Male ; Physical Conditioning, Animal/physiology ; Rats, Wistar ; Reproducibility of Results ; Streptozocin ; Time Factors
مستخلص: Objective: To test whether swimming training benefits femoral neck strength in young diabetic rats under insulin therapy.
Methods: A total of 60 male Wistar rats (age: 40 days) were divided equally into the following six groups: control sedentary, control exercise, diabetic sedentary, diabetic exercise, diabetic sedentary plus insulin and diabetic exercise plus insulin. Diabetes was induced with a unique intraperitoneal injection (60 mg/kg body weight) of streptozotocin. Seven days after the injection and after 12 hours of fasting, the animals with blood glucose levels ≥300 mg/dL were considered diabetic. Seven days after the induction of diabetes, the animals in the exercise groups were subjected to progressive swimming training (final week: 90 min/day; 5 days/week; 5% load) for eight weeks. The animals in the insulin groups received a daily dose of insulin (2-4 U/day) for the same period.
Results: Severe streptozotocin-induced diabetes reduced the structural properties of the femoral neck (trabecular bone volume, trabecular thickness and collagen fiber content). The femoral neck mechanical properties (maximum load and tenacity) were also impaired in the diabetic rats. Insulin therapy partially reversed the damage induced by diabetes on the structural properties of the bone and mitigated the reductions in the mechanical properties of the bone. The combination of therapies further increased the femoral neck trabecular bone volume (∼30%), trabecular thickness (∼24%), collagen type I (∼19%) and type III (∼13%) fiber contents, maximum load (∼25%) and tenacity (∼14%).
Conclusions: Eight weeks of swimming training potentiates the recovery of femoral neck strength in young rats with severe streptozotocin-induced diabetes under insulin therapy.
References: Int J Biochem Cell Biol. 2004 May;36(5):840-8. (PMID: 15006636)
PLoS One. 2013 Aug 07;8(8):e70119. (PMID: 23950908)
Am J Physiol Endocrinol Metab. 2005 Nov;289(5):E735-45. (PMID: 16215165)
Nat Rev Endocrinol. 2017 Apr;13(4):208-219. (PMID: 27658727)
Calcif Tissue Int. 2009 Jan;84(1):45-55. (PMID: 19067021)
Bone. 2008 Sep;43(3):532-8. (PMID: 18599391)
J Bone Miner Metab. 2005;23(1):58-68. (PMID: 15616896)
Bone. 2003 Jun;32(6):660-8. (PMID: 12810173)
Diabetes Res Clin Pract. 2012 Sep;97(3):461-7. (PMID: 22483749)
J Bone Miner Res. 2008 Dec;23(12):1884-91. (PMID: 18665784)
Bone. 2011 Apr 1;48(4):733-40. (PMID: 21185416)
J Appl Physiol (1985). 2015 Nov 1;119(9):990-7. (PMID: 26338454)
Osteoporos Int. 2010 Feb;21(2):195-214. (PMID: 19760059)
J Bone Miner Res. 1996 Jul;11(7):931-7. (PMID: 8797113)
J Diabetes Complications. 2011 Jan-Feb;25(1):19-24. (PMID: 19955005)
J Exerc Nutrition Biochem. 2017 Jun 30;21(2):48-55. (PMID: 28715886)
Calcif Tissue Int. 2009 Oct;85(4):277-86. (PMID: 19760298)
Endocrinology. 1985 Jan;116(1):296-302. (PMID: 3880543)
Osteoporos Int. 2006;17(7):986-95. (PMID: 16552468)
J Orthop Res. 1993 Mar;11(2):263-71. (PMID: 8483039)
Injury. 2002 Dec;33 Suppl 3:C1-7. (PMID: 12423584)
Int J Sports Med. 2017 Dec;38(14):1126-1131. (PMID: 29258155)
Osteoporos Int. 2006 Oct;17(10):1514-23. (PMID: 16770520)
Diabetes. 2016 Jul;65(7):1757-66. (PMID: 27329951)
J Bone Miner Res. 2006 Mar;21(3):477-83. (PMID: 16491296)
Am J Physiol. 1980 Mar;238(3):E200-7. (PMID: 6989262)
Cell Biochem Funct. 2010 Jun;28(4):334-41. (PMID: 20517899)
Cells Tissues Organs. 2009;189(1-4):33-7. (PMID: 18703871)
J Sci Med Sport. 2017 May;20(5):438-445. (PMID: 27840033)
Bone. 2003 Jun;32(6):652-9. (PMID: 12810172)
Int J Low Extrem Wounds. 2011 Mar;10(1):16-32. (PMID: 21444607)
المشرفين على المادة: 0 (Blood Glucose)
0 (Hypoglycemic Agents)
0 (Insulin)
5W494URQ81 (Streptozocin)
9007-34-5 (Collagen)
تواريخ الأحداث: Date Created: 20190501 Date Completed: 20191230 Latest Revision: 20220629
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6474315
DOI: 10.6061/clinics/2019/e829
PMID: 31038563
قاعدة البيانات: MEDLINE
الوصف
تدمد:1980-5322
DOI:10.6061/clinics/2019/e829