دورية أكاديمية
أعرض في EDS

Protective effect of the glucagon-like peptide-1 analogue liraglutide on carbon tetrachloride-induced acute liver injury in mice.

التفاصيل البيبلوغرافية
العنوان: Protective effect of the glucagon-like peptide-1 analogue liraglutide on carbon tetrachloride-induced acute liver injury in mice.
المؤلفون: Zhang WY; Department of Geriatrics, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, China., Hu XF; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China., Wan N; Department of Geriatrics, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, China., Zhang JF; Department of Geriatrics, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, China., Yang P; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China., Wen Q; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China., Chen WJ; Department of Rehabilitation, Huazhong University of Science and Technology Hospital, Huazhong University of Science and Technology, China., Zhu F; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China., Liang ML; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China., Cheng LX; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China. Electronic address: chenglongxian@sina.com., Shu YW; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China. Electronic address: yanwenshu163@163.com.
المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2019 Jun 25; Vol. 514 (2), pp. 386-392. Date of Electronic Publication: 2019 Apr 29.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE
أسماء مطبوعة: Publication: <2002- >: San Diego, CA : Elsevier
Original Publication: New York, Academic Press.
مواضيع طبية MeSH: Carbon Tetrachloride*, Chemical and Drug Induced Liver Injury/*prevention & control , Liraglutide/*pharmacology , Protective Agents/*pharmacology, Animals ; Apoptosis/drug effects ; Cell Respiration/drug effects ; Heme Oxygenase-1/metabolism ; Hepatocytes/drug effects ; Hepatocytes/pathology ; Liver/drug effects ; Liver/pathology ; Male ; Malondialdehyde/metabolism ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred BALB C ; Mitochondria/drug effects ; Mitochondria/metabolism ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/drug effects ; Proliferating Cell Nuclear Antigen/metabolism ; Signal Transduction/drug effects ; Superoxide Dismutase/metabolism
مستخلص: Acute liver injury seriously endangers human health. Liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, has antioxidative effects in addition to being widely used in the treatment of type 2 diabetes and was reported to ameliorate liver diseases. The aim of this study was to evaluate the hepatoprotective effects of liraglutide on carbon tetrachloride (CCl4)-induced acute liver injury in mice and to investigate the mechanisms involved in this protective effect. Male BALB/c mice were pre-treated with liraglutide (200 μg/kg/day) by hypodermic injection for 3 days before a 0.1% (v/v) CCl4 (10 ml/kg, dissolved in olive oil) intraperitoneal injection, or post-treated with liraglutide once immediately after a CCl4 intraperitoneal injection. The experimental data showed that liraglutide treatment significantly decreased the serum ALT and AST levels and ameliorated the liver histopathological changes induced by CCl4. In addition, liraglutide pre-treatment dramatically increased the number of proliferating cell nuclear antigen (PCNA)-positive hepatocytes and significantly reduced hepatocyte apoptosis after CCl4 treatment. As a consequence, liraglutide pre-treatment significantly prevented CCl4-induced malondialdehyde (MDA) production and increased the activity of the antioxidant superoxide dismutase (SOD) enzyme. In addition, liraglutide pre-treatment significantly ameliorated mitochondrial respiratory functions and ultrastructural features. Furthermore, liraglutide pre-treatment enhances the activation of the NRF2/HO-1 signaling pathway. In summary, liraglutide protects against CCl4-induced acute liver injury by protecting mitochondrial functions and inhibiting oxidative stress, which may partly involve the activation of NRF2/HO-1 signaling pathway.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Acute liver injury; Carbon tetrachloride; Liraglutide; Mitochondria; NRF2/HO-1; Oxidative stress
المشرفين على المادة: 0 (Membrane Proteins)
0 (NF-E2-Related Factor 2)
0 (Nfe2l2 protein, mouse)
0 (Proliferating Cell Nuclear Antigen)
0 (Protective Agents)
4Y8F71G49Q (Malondialdehyde)
839I73S42A (Liraglutide)
CL2T97X0V0 (Carbon Tetrachloride)
EC 1.14.14.18 (Heme Oxygenase-1)
EC 1.14.14.18 (Hmox1 protein, mouse)
EC 1.15.1.1 (Superoxide Dismutase)
تواريخ الأحداث: Date Created: 20190504 Date Completed: 20200706 Latest Revision: 20200706
رمز التحديث: 20240628
DOI: 10.1016/j.bbrc.2019.04.160
PMID: 31047638
قاعدة البيانات: MEDLINE
الوصف
تدمد:1090-2104
DOI:10.1016/j.bbrc.2019.04.160