دورية أكاديمية
Evaluation of the antiulcer activity of the aqueous stem bark extract of Balanites aegyptiaca L Delile in Wistar rats.
| العنوان: | Evaluation of the antiulcer activity of the aqueous stem bark extract of Balanites aegyptiaca L Delile in Wistar rats. |
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| المؤلفون: | Ugwah MO; Department of Pharmacy, Usmanu Danfodiyo University Teaching Hospital, P.M.B., 2370, Sokoto, Nigeria. Electronic address: mikeugwah@yahoo.com., Ugwah-Oguejiofor CJ; Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, P.M.B, 2346, Sokoto, Nigeria. Electronic address: nenye789@yahoo.com., Etuk EU; Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Health Sciences, Usmanu Danfodiyo University, P.M.B, 2346, Sokoto, Nigeria. Electronic address: etuk2005@yahoo.co.uk., Bello SO; Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Health Sciences, Usmanu Danfodiyo University, P.M.B, 2346, Sokoto, Nigeria. Electronic address: bellooricha@yahoo.com., Aliero AA; Department of Botany, Faculty of Biological Sciences, Usmanu Danfodiyo University, P.M.B, 2346, Sokoto, Nigeria. Electronic address: aaliero@yahoo.com. |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2019 Jul 15; Vol. 239, pp. 111931. Date of Electronic Publication: 2019 May 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Balanites*, Anti-Ulcer Agents/*therapeutic use , Plant Extracts/*therapeutic use , Stomach Ulcer/*drug therapy, Acetic Acid ; Animals ; Ethanol ; Indomethacin ; Ligation ; Male ; Phytotherapy ; Plant Bark ; Plant Stems ; Pylorus/surgery ; Rats, Wistar ; Stomach Ulcer/chemically induced |
| مستخلص: | Ethnopharmacological Relevance: Balanites aegyptiaca L. Delile (Zygophyllaceae) is a perennial tree that is mostly found in Africa, south Asia and most desert environments. Decoctions of its stem barks are used in northern Nigeria for the treatment of ulcers and stomach issues. Other folkloric uses include treatment of wounds, malaria, dysentery, asthma, and fever. Aim of the Study: The present study evaluated the antiulcer activity of the aqueous stem bark extract of Balanites aegyptiaca in Wistar rats. Materials and Methods: The antiulcer activity of the aqueous stem bark extract of Balanites aegyptiaca (125, 250 and 500 mg/kg, p.o.) was evaluated in ethanol, indomethacin, pylorus ligation and acetic acid-induced ulcer models in rats. Parameters such as mean ulcer indices and percentage ulcer inhibition were assessed in ethanol, indomethacin and acetic acid-induced ulcer models while gastric volume, pH, and titratable acidity were evaluated in the pylorus ligation ulcer model. Results: The extract at the doses of 125, 250 and 500 mg/kg caused a significant (p < 0.01), dose dependent reduction in mean ulcer indices in the ethanol and indomethacin ulcer models. A significant dose dependent reduction in mean ulcer indices were also observed after three (p < 0.01) and seven (p < 0.001) days of treatment with the extract in acetic acid-induced ulcer model. In pylorus ligation model, the gastric secretion parameters (gastric volume, pH, and titratable acidity) showed no alteration in the different doses of the extract when compared to the control. Conclusion: Our study showed that the aqueous stem bark extract of Balanites aegyptiaca possesses gastroprotective and ulcer healing properties and therefore not only provides scientific evidence for its folkloric use in the treatment of ulcers but also showed evidence that it may be used in the development of a new phytotherapeutic formulation for the treatment of peptic ulcer. (Copyright © 2019 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antiulcer; Balanites aegyptiaca; Gastroprotection; Traditional medicine; Ulcer healing |
| المشرفين على المادة: | 0 (Anti-Ulcer Agents) 0 (Plant Extracts) 3K9958V90M (Ethanol) Q40Q9N063P (Acetic Acid) XXE1CET956 (Indomethacin) |
| تواريخ الأحداث: | Date Created: 20190506 Date Completed: 20200106 Latest Revision: 20200106 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jep.2019.111931 |
| PMID: | 31055003 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7573 |
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| DOI: | 10.1016/j.jep.2019.111931 |