دورية أكاديمية
Prevalence of non-tuberculous mycobacteria in HIV-infected patients admitted to hospital with pneumonia.
| العنوان: | Prevalence of non-tuberculous mycobacteria in HIV-infected patients admitted to hospital with pneumonia. |
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| المؤلفون: | Lapinel NC; Section of Pulmonary/Critical Care Medicine & Allergy/Immunology, Louisiana State University, New Orleans, Louisiana, USA., Jolley SE; Section of Pulmonary/Critical Care Medicine & Allergy/Immunology, Louisiana State University, New Orleans, Louisiana, USA., Ali J; Section of Pulmonary/Critical Care Medicine & Allergy/Immunology, Louisiana State University, New Orleans, Louisiana, USA., Welsh DA; Section of Pulmonary/Critical Care Medicine & Allergy/Immunology, Louisiana State University, New Orleans, Louisiana, USA. |
| المصدر: | The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2019 Apr 01; Vol. 23 (4), pp. 491-497. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: The Union Country of Publication: France NLM ID: 9706389 Publication Model: Print Cited Medium: Internet ISSN: 1815-7920 (Electronic) Linking ISSN: 10273719 NLM ISO Abbreviation: Int J Tuberc Lung Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Paris, France : The Union, c1997- |
| مواضيع طبية MeSH: | HIV Infections/*complications , Mycobacterium Infections, Nontuberculous/*epidemiology , Nontuberculous Mycobacteria/*isolation & purification , Pneumonia/*epidemiology, AIDS-Related Opportunistic Infections/diagnosis ; AIDS-Related Opportunistic Infections/epidemiology ; AIDS-Related Opportunistic Infections/microbiology ; Adult ; Bronchoalveolar Lavage Fluid/microbiology ; Cohort Studies ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Mycobacterium Infections, Nontuberculous/diagnosis ; Pneumonia/diagnosis ; Pneumonia/microbiology ; Prevalence ; Prospective Studies ; Sputum/microbiology |
| مستخلص: | BACKGROUNDPeople living with the human immunodeficiency virus (PLWH) may be particularly vulnerable to the consequences of non-tuberculous mycobacteria (NTM) given their defective T cell-mediated immunity and high rates of structural lung disease.OBJECTIVETo determine the prevalence of NTM in PLWH hospitalized with pneumonia and to assess the potential predictors of NTM isolation.METHODSSecondary data analysis of a prospective cohort study (2007-2011) of early bronchoscopy in PLWH presenting with suspected pneumonia was undertaken. Subjects with any species of NTM, henceforth described as 'NTM of undetermined significance' (NTM-US), isolated from sputum or bronchoalveolar lavage fluid (BALF), were included in the analysis. Potential predictors were chosen a priori.RESULTSAmong 196 HIV-infected subjects hospitalized with pneumonia, 96 had respiratory samples positive for NTM-US, with 91% of all NTM-US isolated from sputum compared with BALF. The overall prevalence of NTM-US was 49% (96/196). More NTM subjects were smokers ( P = 0.08), with a history of chronic obstructive pulmonary disease ( P = 0.08). Among those with pathogenic NTM, 39% (34/88) would have met American Thoracic Society microbiologic criteria for NTM pulmonary disease (17% of total cohort).CONCLUSIONSRespiratory cultures, predominantly sputum samples, were positive for NTM-US in 45% of HIV-infected subjects admitted to hospital for pneumonia. Further research is needed to characterize the prevalence of NTM in PLWH and help establish specific diagnostic criteria in this population. |
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| معلومات مُعتمدة: | P60 AA009803 United States AA NIAAA NIH HHS; K23 AA026315 United States AA NIAAA NIH HHS; U54 GM104940 United States GM NIGMS NIH HHS; R24 AA019661 United States AA NIAAA NIH HHS; P01 HL076100 United States HL NHLBI NIH HHS; UH2 AA026226 United States AA NIAAA NIH HHS |
| تواريخ الأحداث: | Date Created: 20190509 Date Completed: 20200205 Latest Revision: 20220224 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6855835 |
| DOI: | 10.5588/ijtld.18.0336 |
| PMID: | 31064629 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1815-7920 |
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| DOI: | 10.5588/ijtld.18.0336 |