دورية أكاديمية
Clinicopathologic Diagnostic and Prognostic Factors of Spindle Cell Carcinoma of Upper Airway.
| العنوان: | Clinicopathologic Diagnostic and Prognostic Factors of Spindle Cell Carcinoma of Upper Airway. |
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| المؤلفون: | de Araújo AB; Department of Otorhinolaryngology, Head Neck, University of Campinas, UNICAMP, PO BOX 6111, Campinas, São Paulo, Postal Code: 13081-970, Brazil. mandibueno@hotmail.com., Serrano TLI; Department of Otorhinolaryngology, Head Neck, University of Campinas, UNICAMP, PO BOX 6111, Campinas, São Paulo, Postal Code: 13081-970, Brazil., Pedroso MCM; Department of Otorhinolaryngology, Head Neck, University of Campinas, UNICAMP, PO BOX 6111, Campinas, São Paulo, Postal Code: 13081-970, Brazil., Mariano FV; Department of Surgical Pathology, University of Campinas, UNICAMP, Campinas, São Paulo, Brazil., Altemani A; Department of Surgical Pathology, University of Campinas, UNICAMP, Campinas, São Paulo, Brazil., Gripp FM; Department of Otorhinolaryngology, Head Neck, University of Campinas, UNICAMP, PO BOX 6111, Campinas, São Paulo, Postal Code: 13081-970, Brazil., Crespo AN; Department of Otorhinolaryngology, Head Neck, University of Campinas, UNICAMP, PO BOX 6111, Campinas, São Paulo, Postal Code: 13081-970, Brazil., Chone CT; Department of Otorhinolaryngology, Head Neck, University of Campinas, UNICAMP, PO BOX 6111, Campinas, São Paulo, Postal Code: 13081-970, Brazil. |
| المصدر: | Pathology oncology research : POR [Pathol Oncol Res] 2020 Apr; Vol. 26 (2), pp. 1097-1104. Date of Electronic Publication: 2019 May 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 9706087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2807 (Electronic) Linking ISSN: 12194956 NLM ISO Abbreviation: Pathol Oncol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : Lausanne, Switzerland : Frontiers Media S. A. Original Publication: Budapest, Hungary : Science Press, c1995- |
| مواضيع طبية MeSH: | Carcinosarcoma/*diagnosis , Carcinosarcoma/*pathology , Laryngeal Neoplasms/*diagnosis , Laryngeal Neoplasms/*pathology , Mouth Neoplasms/*diagnosis , Mouth Neoplasms/*pathology, Aged ; Carcinosarcoma/mortality ; Cohort Studies ; Disease-Free Survival ; Female ; Humans ; Laryngeal Neoplasms/mortality ; Male ; Middle Aged ; Mouth Neoplasms/mortality ; Retrospective Studies |
| مستخلص: | Spindle cell carcinoma (SpCC) is a rare tumor, which occurs in upper respiratory tract, mainly in larynx. This study aimed to review the clinical and pathological characteristics for diagnosis and prognosis. Retrospective cohort study. All patients with SpCC in upper respiratory tract treated for curative intent was included. All patients were reviewed in search of epithelial component and immunohistochemistry when not found. It was evaluated rate of recurrence and disease-free survival with univariate and multivariate analysis with Kaplan Meier and Cox Regression model adjusted to propensity score indexes (PSI) according to age, gender, site of tumor, stage, surgical treatment, status of margins of surgical resection, lymphatic invasion. There were 16 cases of SpCC.31% were diagnosed with light microscopy and others with immunohistochemistry for epithelial marker. Disease-free survival was higher in early stage disease in univariate and multivariate analysis, as the main prognostic factor. Surgical treatment increases in 2.54 the rate of survival. The SpCC is a rare tumor considered a highly malignant variant of squamous cell carcinoma. It has male predominance and tobacco use as risk factors. Its treatment should follow the same recommendations for squamous cell carcinoma, with surgery as the maintain treatment. Immunohistochemistry is an adjuvant important tool for diagnosis of SpCC. |
| فهرسة مساهمة: | Keywords: Head and neck cancer; Immunohistochemistry; Prognostic factors; Sarcomatoid carcinoma; Spindle cell carcinoma |
| تواريخ الأحداث: | Date Created: 20190510 Date Completed: 20210331 Latest Revision: 20210331 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1007/s12253-019-00654-9 |
| PMID: | 31069711 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1532-2807 |
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| DOI: | 10.1007/s12253-019-00654-9 |