دورية أكاديمية
Forced internal desynchrony induces cardiometabolic alterations in adult rats.
العنوان: | Forced internal desynchrony induces cardiometabolic alterations in adult rats. |
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المؤلفون: | de Oliveira IGB; Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil., Junior MDF; Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil., Lopes PR; Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil., Campos DBT; Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil., Ferreira-Neto ML; Departament of Physiology, Institute of Biomedical Science, Laboratory of Electrophysiology and Cardiovascular Physiology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil., Santos EHR; Departament of Physiology, Institute of Biomedical Science, Laboratory of Electrophysiology and Cardiovascular Physiology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil., Mathias PCF; Department of Biotechnology, Genetics and Cell Biology, Laboratory of Secretion Cell Biology, State University of Maringá, Maringá, Paraná, Brazil., Francisco FA; Department of Biotechnology, Genetics and Cell Biology, Laboratory of Secretion Cell Biology, State University of Maringá, Maringá, Paraná, Brazil., Koike BDV; Medical Department, Federal University of San Francisco Valley, Petrolina, Pernambuco, Brazil., de Castro CH; Department of Physiological Science, Integrative Laboratory of Cardiovascular and Neurological Pathophysiology, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil., Freiria-Oliveira AH; Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil., Pedrino GR; Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil., Gomes RM; Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil., Rosa DA; Center of Neuroscience and Cardiovascular Research, Biological Science Institute, Federal University of Goiás, Goiânia, Goiás, Brazil. |
المصدر: | The Journal of endocrinology [J Endocrinol] 2019 Aug; Vol. 242 (2), pp. 25-36. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: BioScientifica Country of Publication: England NLM ID: 0375363 Publication Model: Print Cited Medium: Internet ISSN: 1479-6805 (Electronic) Linking ISSN: 00220795 NLM ISO Abbreviation: J Endocrinol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Jan. 2011- : Bristol, UK : BioScientifica Original Publication: Bristol, UK : Society for Endocrinology |
مواضيع طبية MeSH: | Photoperiod*, Cardiovascular Diseases/*metabolism , Circadian Rhythm/*physiology , Motor Activity/*physiology , Suprachiasmatic Nucleus/*physiology, Adrenal Glands/pathology ; Animals ; Cardiovascular Diseases/physiopathology ; Dyslipidemias/blood ; Hypertrophy ; Male ; Rats, Wistar ; Suprachiasmatic Nucleus/metabolism |
مستخلص: | Disruptions in circadian rhythms have been associated with several diseases, including cardiovascular and metabolic disorders. Forced internal desynchronization induced by a period of T-cycles of 22 h (T22 protocol) reaches the lower limit of entrainment and dissociates the circadian rhythmicity of the locomotor activity into two components, driven by different outputs from the suprachiasmatic nucleus (SCN). The main goal of this study was to evaluate the cardiovascular and metabolic response in rats submitted to internal desynchronization by T22 protocol. Male Wistar rats were assigned to either a control group subjected to a usual T-cycles of 24 h (12 h-12 h) or an experimental group subjected to the T22 protocol involving a 22-h symmetric light-dark cycle (11 h-11 h). After 8 weeks, rats subjected to the T22 exhibited desynchrony in their locomotor activity. Although plasma glucose and insulin levels were similar in both groups, desynchronized rats demonstrated dyslipidemia, significant hypertrophy of the fasciculate zone of the adrenal gland, low IRB, IRS2, PI3K, AKT, SOD and CAT protein expression and an increased expression of phosphoenolpyruvate carboxykinase in the liver. Furthermore, though they maintained normal baseline heart rates and mean arterial pressure levels, they also presented reduced baroreflex sensitivity. The findings indicate that circadian timing desynchrony following the T22 protocol can induce cardiometabolic disruptions. Early hepatic metabolism dysfunction can trigger other disorders, though additional studies are needed to clarify the causes. |
فهرسة مساهمة: | Keywords: blood pressure; circadian rhythms; corticosteroids; insulin resistance; metabolism |
تواريخ الأحداث: | Date Created: 20190510 Date Completed: 20200406 Latest Revision: 20200408 |
رمز التحديث: | 20240628 |
DOI: | 10.1530/JOE-19-0026 |
PMID: | 31071682 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1479-6805 |
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DOI: | 10.1530/JOE-19-0026 |