دورية أكاديمية
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Cecropia pachystachya Leaves Present Potential to Be Used as New Ingredient for Antiaging Dermocosmetics.

التفاصيل البيبلوغرافية
العنوان: Cecropia pachystachya Leaves Present Potential to Be Used as New Ingredient for Antiaging Dermocosmetics.
المؤلفون: Fernandes MF; Laboratory of Bioactive Natural Products, Department of Biochemistry, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil., Conegundes JLM; Laboratory of Bioactive Natural Products, Department of Biochemistry, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil., Pinto NCC; Laboratory of Bioactive Natural Products, Department of Biochemistry, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil., de Oliveira LG; Glycoconjugate Analysis Laboratory, Department of Biochemistry, Biological Sciences Institute, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil., de Aguiar JAK; Glycoconjugate Analysis Laboratory, Department of Biochemistry, Biological Sciences Institute, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil., Souza-Fagundes EM; Department of Physiology and Biophysics, Biological Sciences Institute, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil., Scio E; Laboratory of Bioactive Natural Products, Department of Biochemistry, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil.
المصدر: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2019 Apr 03; Vol. 2019, pp. 8263934. Date of Electronic Publication: 2019 Apr 03 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub Country of Publication: United States NLM ID: 101215021 Publication Model: eCollection Cited Medium: Print ISSN: 1741-427X (Print) Linking ISSN: 1741427X NLM ISO Abbreviation: Evid Based Complement Alternat Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2011- : New York, NY : Hindawi Pub.
Original Publication: Oxford, UK : Oxford University Press, c2004-
مستخلص: Several biological activities have been reported for leaf extracts of Cecropia pachystachya species, including antioxidant and wound healing activities. This study aims to report, for the first time, the antiaging potential of the hydroethanolic (HE) and the ethanolic (EE) extracts obtained from the leaves of C. pachystachya using different in vitro assays. Both HE and EE presented relevant antioxidant capacity in different models, including phosphomolybdenum, 1,1-diphenyl-2-picryl-hydrazyl (DPPH), carotene/linoleic acid bleaching, and thiobarbituric acid reactive substances (TBARS) assays. Their ability to prevent the production of advanced glycation end products (AGEs) was also evaluated, and both extracts showed important activity, especially HE. The extracts also stimulated the fibroblasts proliferation in vitro , specialized cells that produce several mediators which maintain the skin integrity and youthfulness. Cytotoxicity of the extracts was not observed for this lineage or HEK-293, human embryonic kidney cells widely used to evaluate cytotoxicity of chemical compounds. HE also exhibited the ability to inhibit the collagenase (metalloproteinase MMP-2) and elastase activities. The total phenolic and flavonoids contents were also determined. HPLC analysis revealed the presence of the flavonoids orientin and iso-orientin, which were quantified to be used as chemical markers. The results suggested that the extracts of C. pachystachya leaves present the potential to be used in dermocosmetic formulations to prevent the skin aging process, which attracts the attention of pharmaceutical companies and researchers interested in the development of novel ingredients likely to be used as active principles in antiaging products.
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تواريخ الأحداث: Date Created: 20190511 Latest Revision: 20200930
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6470440
DOI: 10.1155/2019/8263934
PMID: 31073319
قاعدة البيانات: MEDLINE
الوصف
تدمد:1741-427X
DOI:10.1155/2019/8263934