دورية أكاديمية
أعرض في EDS

Clinical implications of early caudate dysfunction in Parkinson's disease.

التفاصيل البيبلوغرافية
العنوان: Clinical implications of early caudate dysfunction in Parkinson's disease.
المؤلفون: Pasquini J; Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, University of Milan, Milan, Italy.; Department of Neurology - Stroke Unit and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy., Durcan R; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK., Wiblin L; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK., Gersel Stokholm M; Department of Nuclear Medicine and PET Centre, Aarhus Universitetshospital, Aarhus, Denmark., Rochester L; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.; Newcastle upon Tyne Hospitals, NHS Foundation Trust, Newcastle upon Tyne, UK., Brooks DJ; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.; Department of Nuclear Medicine and PET Centre, Aarhus Universitetshospital, Aarhus, Denmark., Burn D; Newcastle upon Tyne Hospitals, NHS Foundation Trust, Newcastle upon Tyne, UK.; Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Pavese N; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK Nicola.Pavese@newcastle.ac.uk.; Department of Nuclear Medicine and PET Centre, Aarhus Universitetshospital, Aarhus, Denmark.
المصدر: Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2019 Oct; Vol. 90 (10), pp. 1098-1104. Date of Electronic Publication: 2019 May 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 2985191R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-330X (Electronic) Linking ISSN: 00223050 NLM ISO Abbreviation: J Neurol Neurosurg Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: London : BMJ Publishing Group
Original Publication: London : British Medical Association
مواضيع طبية MeSH: Caudate Nucleus/*physiopathology , Cognitive Dysfunction/*physiopathology , Depression/*physiopathology , Dopamine Plasma Membrane Transport Proteins/*metabolism , Gait Disorders, Neurologic/*physiopathology , Parkinson Disease/*physiopathology, Aged ; Case-Control Studies ; Caudate Nucleus/diagnostic imaging ; Caudate Nucleus/metabolism ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/psychology ; Depression/metabolism ; Depression/psychology ; Disease Progression ; Female ; Gait Disorders, Neurologic/metabolism ; Humans ; Male ; Middle Aged ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/metabolism ; Parkinson Disease/psychology ; Tomography, Emission-Computed, Single-Photon ; Tropanes
مستخلص: Objective: Although not typical of Parkinson's disease (PD), caudate dopaminergic dysfunction can occur in early stages of the disease. However, its frequency and longitudinal implications in large cohorts of recently diagnosed patients remain to be established. We investigated the occurrence of caudate dopaminergic dysfunction in the very early phases of PD (<2 years from diagnosis) using 123 I-FP-CIT single photon emission CT and determined whether it was associated with the presence or subsequent development of cognitive impairment, depression, sleep and gait problems.
Methods: Patients with PD and healthy controls were identified from the Parkinson's Progression Markers Initiative (PPMI) database. We defined a clinically significant caudate dysfunction as 123 I-FP-CIT binding <-2 SDs compared with the controls' mean and categorised three groups accordingly (no reduction, unilateral reduction, bilateral reduction). All statistical analyses were adjusted for mean putamen binding.
Results: At baseline, 51.6% of 397 patients had normal caudate dopamine transporter binding, 26.0% had unilateral caudate involvement, 22.4% had bilaterally impaired caudate.Compared with those with a baseline normal caudate function, at the4-year follow-up patients with a baseline bilateral caudate involvement showed a higher frequency of cognitive impairment (p<0.001) and depression (p<0.001), and worse cognitive (p<0.001), depression (<0.05) and gait (<0.001) ratings. Significant caudate involvement was observed in 83.9% of the population after 4 years (unilateral 22.5%, bilateral 61.4%).
Conclusions: Early significant caudate dopaminergic denervation was found in half of the cases in the PPMI series. Baseline bilateral caudate involvement was associated with increased risk of developing cognitive impairment, depression and gait problems over the next 4 years.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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فهرسة مساهمة: Keywords: caudate; cognitive impairment; depression; gait problems; parkinson’s disease
المشرفين على المادة: 0 (Dopamine Plasma Membrane Transport Proteins)
0 (Tropanes)
155797-99-2 (2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane)
تواريخ الأحداث: Date Created: 20190513 Date Completed: 20200618 Latest Revision: 20200618
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6817982
DOI: 10.1136/jnnp-2018-320157
PMID: 31079063
قاعدة البيانات: MEDLINE
الوصف
تدمد:1468-330X
DOI:10.1136/jnnp-2018-320157