دورية أكاديمية
Islet amyloidosis in a child with type 1 diabetes.
| العنوان: | Islet amyloidosis in a child with type 1 diabetes. |
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| المؤلفون: | Beery ML; a Departments of Pathology, Immunology, and Laboratory Medicine , University of Florida , Gainesville , FL , USA., Jacobsen LM; b Departments of Pediatrics , University of Florida , Gainesville , FL , USA., Atkinson MA; a Departments of Pathology, Immunology, and Laboratory Medicine , University of Florida , Gainesville , FL , USA.; b Departments of Pediatrics , University of Florida , Gainesville , FL , USA., Butler AE; c Diabetes Research Center , Qatar Biomedical Research Institute , Doha , Qatar., Campbell-Thompson M; a Departments of Pathology, Immunology, and Laboratory Medicine , University of Florida , Gainesville , FL , USA. |
| المصدر: | Islets [Islets] 2019; Vol. 11 (2), pp. 44-49. Date of Electronic Publication: 2019 May 14. |
| نوع المنشور: | Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495366 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-2022 (Electronic) Linking ISSN: 19382014 NLM ISO Abbreviation: Islets Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Philapdelphia, PA : Taylor & Francis Original Publication: Austin, TX : Landes Bioscience |
| مواضيع طبية MeSH: | Amyloidosis/*pathology , Diabetes Mellitus, Type 1/*pathology , Islets of Langerhans/*pathology, Amyloidosis/complications ; Case-Control Studies ; Child ; Diabetes Mellitus, Type 1/complications ; Female ; Humans ; Male ; Young Adult |
| مستخلص: | Histopathology based studies of the pancreas obtained from organ donors are increasing our awareness of islet phenotypic heterogeneity during development and aging, as well as in settings of type 1 diabetes, type 2 diabetes, monogenic diabetes or other forms of this metabolic disease. Islet amyloidosis represents a histopathological feature classically ascribed to patients with type 2 diabetes. Herein, the occurrence of islet amyloidosis and its severity are reported in a child with type 1 diabetes along with histological comparisons of islet amyloidosis in two young adults with recent-onset type 1 diabetes. Islet amyloidosis was infrequent yet widely distributed throughout the pancreas in the child with type 1 diabetes and both adults with type 1 diabetes, with no such pathology seen in matched control donors. Analysis of these cases add to the increasing appreciation of islet heterogeneity in children and young adults with type 1 diabetes. Such knowledge also supports a notion that multiple pathophysiological mechanisms underlie the loss of functional β-cell mass in the spectrum of clinical phenotypes in patients with type 1 diabetes. |
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| فهرسة مساهمة: | Keywords: Histopathology; amylin; heterogeneity; insulitis; islet amyloid polypeptide; pancreas |
| تواريخ الأحداث: | Date Created: 20190516 Date Completed: 20191230 Latest Revision: 20200309 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6548483 |
| DOI: | 10.1080/19382014.2019.1599707 |
| PMID: | 31084520 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1938-2022 |
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| DOI: | 10.1080/19382014.2019.1599707 |