دورية أكاديمية
CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection.
العنوان: | CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection. |
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المؤلفون: | Palchevskiy V; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Xue YY; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Kern R; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Weigt SS; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Gregson AL; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Song SX; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Fishbein MC; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Hogaboam CM; Pulmonary & Critical Care Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Sayah DM; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Lynch JP 3rd; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA., Keane MP; University College Dublin School of Medicine, Respiratory Medicine, St Vincent's University Hospital, Dublin, Ireland., Brooks DG; Princess Margaret Cancer Center, University Health Network and Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Belperio JA; Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA. |
المصدر: | JCI insight [JCI Insight] 2019 May 14; Vol. 5. Date of Electronic Publication: 2019 May 14. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Ann Arbor, Michigan : American Society for Clinical Investigation, [2016]- |
مواضيع طبية MeSH: | Graft Rejection/*immunology , Lung Transplantation/*adverse effects , Receptors, CCR4/*metabolism , T-Lymphocytes/*immunology, Adoptive Transfer ; Allografts/immunology ; Allografts/pathology ; Animals ; Disease Models, Animal ; Female ; Graft Rejection/pathology ; Graft Survival/immunology ; Humans ; Lung/immunology ; Lung/pathology ; Mice ; Mice, Knockout ; Proof of Concept Study ; Receptors, CCR4/genetics ; Receptors, CCR4/immunology ; Signal Transduction/genetics ; Signal Transduction/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes/transplantation ; Transplantation, Homologous/adverse effects |
مستخلص: | Despite current immunosuppressive strategies, long-term lung transplant outcomes remain poor due to rapid allogenic responses. Using a stringent mouse model of allo-airway transplantation, we identify the CCR4-ligand axis as a central node driving secondary lymphoid tissue homing and activation of the allogeneic T cells that prevent long-term allograft survival. CCR4 deficiency on transplant recipient T cells diminishes allograft injury and when combined with CTLA4-Ig leads to an unprecedented long-term lung allograft accommodation. Thus, we identify CCR4-ligand interactions as a central mechanism driving allogeneic transplant rejection and suggest it as a potential target to enhance long-term lung transplant survival. |
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معلومات مُعتمدة: | P01 HL108793 United States HL NHLBI NIH HHS; R01 HL112990 United States HL NHLBI NIH HHS |
فهرسة مساهمة: | Keywords: Adaptive immunity; Chemokines; Immunology; T cells; Transplantation |
المشرفين على المادة: | 0 (Ccr4 protein, mouse) 0 (Receptors, CCR4) |
تواريخ الأحداث: | Date Created: 20190516 Date Completed: 20200924 Latest Revision: 20240718 |
رمز التحديث: | 20240718 |
مُعرف محوري في PubMed: | PMC6629140 |
DOI: | 10.1172/jci.insight.121782 |
PMID: | 31085832 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2379-3708 |
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DOI: | 10.1172/jci.insight.121782 |